Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory (Molecular and Translational Medicine)

While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field. Front Matter....Pages i-xiv Front Matter....Pages 1-1 Issues in Translation of Pharmacogenomics into Clinical Practice....Pages 3-14 Molecular Diagnostic Methods in Pharmacogenomics....Pages 15-34 Economics of Pharmacogenomic Testing in Clinical Practice....Pages 35-46 From Personalized Medicine to Personalized Justice: The Promises of Translational Pharmacogenomics in the Justice System....Pages 47-56 Front Matter....Pages 57-57 Irinotecan....Pages 59-75 Pharmacogenomics of Tamoxifen....Pages 77-89 Thiopurines....Pages 91-114 Front Matter....Pages 115-115 The Pharmacogenetics of Vitamin K Antagonist Anticoagulation Drugs....Pages 117-138 Clopidogrel and Salicylates....Pages 139-153 Genotype-Guided Statin Therapy....Pages 155-174 The Statin Response Gene: KIF6....Pages 175-198 Front Matter....Pages 199-199 Abacavir....Pages 201-212 Allopurinol....Pages 213-223 Carbamazepine and Its Structurally-Related Antiepileptics....Pages 225-236 Front Matter....Pages 237-237 Pharmacogenetics of Flucloxacillin and Amoxicillin-Clavulanate Associated Hepatic Dysfunction/Injury....Pages 239-247 Immunosuppressants Pharmacogenomics....Pages 249-265 Back Matter....Pages 267-272 Pharmacogenomic Testing in Current Clinical Practice 4 Preface 6 Acknowledgements 8 Contents 10 Contributors 12 Part I: Basic Concepts 16 Part II: Chemotherapeutics 71 Part III: Specific Pharmacogenomic Targets: Cardiovascular Drugs 126 Part IV: Drugs that Cause Delayed Hypersensitivity 208 Part V: Miscellaneous Drugs 244 Index 271