Pharmacogenetics of Breast Cancer: Towards the Individualization of Therapy (Translational Medicine Book 7)

Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become rout.;Preface -- Acknowledgments -- Contents -- Contributors -- 1 Pharmacogenetics of Breast Cancer: Toward the Individualization of Therapy -- 2 Pharmacology, Pharmacogenetics, and Pharmacoepidemiology: Three P's of Individualized Therapy -- 3 Role of Genetic Variability in Breast Cancer Treatment Outcomes -- 4 The Role of Epigenetics in Breast Cancer: Implications for Diagnosis, Prognosis, and Treatment -- 5 Comparative Genomic Hybridization and Copy Number Abnormalities in Breast Cancer -- 6 Gene Expression Profiling as an Emerging Diagnostic Tool to Personalize Chemotherapy Selection for Early Stage Breast Cancer -- 7 Gene Expression-Based Predictors of Prognosis and Response to Chemotherapy in Breast Cancer -- 8 Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer -- 9 Personalized Medicine by the Use of Microarray Gene Expression Profiling -- 10 Predictive Markers for Targeted Breast Cancer Treatment -- 11 Circulating Tumor Cells in Individualizing Breast Cancer Therapy -- 12 Individualization of Endocrine Therapy in Breast Cancer -- 13 TAILORx: Rationale for the Study Design -- 14 Taking Prognostic Signatures to the Clinic -- 15 Tissue is the Issue -- 16 Acquisition and Preservation of Tissue for Microarray Analysis -- 17 Tapping into the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Gold Mine for Individualization of Breast Cancer Treatment -- 18 Breast Cancer Stem Cells and Their Niche: Lethal Seeds in Lethal Soil -- 19 Molecular Imaging in Individualized Cancer Management -- 20 Cancer Nanotechnology for Molecular Profiling and Individualized Therapy -- Index. Cover......Page 1 Half Title......Page 2 Title Page......Page 4 Copyright Page......Page 5 Preface......Page 6 Acknowledgments......Page 8 Table of Contents......Page 10 Contributors......Page 14 1: Pharmacogenetics of Breast Cancer: Toward the Individualization of Therapy......Page 18 2: Pharmacology, Pharmacogenetics, and Pharmacoepidemiology: Three P’s of Individualized Therapy......Page 28 3: Role of Genetic Variability in Breast Cancer Treatment Outcomes......Page 42 4: The Role of Epigenetics in Breast Cancer: Implications for Diagnosis, Prognosis, and Treatment......Page 62 5: Comparative Genomic Hybridization and Copy Number Abnormalities in Breast Cancer......Page 78 6: Gene Expression Profiling as an Emerging Diagnostic Tool to Personalize Chemotherapy Selection for Early Stage Breast Cancer......Page 94 7: Gene Expression-Based Predictors of Prognosis and Response to Chemotherapy in Breast Cancer......Page 114 8: Utilization of Genomic Signatures for Personalized Treatment of Breast Cancer......Page 124 9: Personalized Medicine by the Use of Microarray Gene Expression Profiling......Page 140 10: Predictive Markers for Targeted Breast Cancer Treatment......Page 152 11: Circulating Tumor Cells in Individualizing Breast Cancer Therapy......Page 168 12: Individualization of Endocrine Therapy in Breast Cancer......Page 184 13: TAILORx: Rationale for the Study Design......Page 202 14: Taking Prognostic Signatures to the Clinic......Page 214 15: Tissue is the Issue......Page 230 16: Acquisition and Preservation of Tissue for Microarray Analysis......Page 248 17: Tapping into the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Gold Mine for Individualization of Breast Cancer Treatment......Page 260 18: Breast Cancer Stem Cells and Their Niche: Lethal Seeds in Lethal Soil......Page 276 19: Molecular Imaging in Individualized Cancer Management......Page 308 20: Cancer Nanotechnology for Molecular Profiling and Individualized Therapy......Page 326 Index......Page 340

pharmacogenetics Is Becoming Increasingly Relevant In The Diagnosis, Treatment, And Recovery Of Cancer Patients. A Major Problem Facing Oncologists Is The Outstanding Varied Efficacy Of Treatment. Promising Advances In Pharmacogenetics Have Allowed The Development Of Effective Agents Which Will Enable Personalized Cancer Chemotherapy To Become Routine For The Clinical Practice.

written By Experts In The Field And Combining Information That Is Unable To Be Found In A Single Source Volume, Pharmacogenetics Of Breast Cancer:

combines A Complete Overview Of Pharmacogenetics And How It Relates To Breast Oncology For Diagnosis, Treatment, And The Recovery Of Patients Using An Individualized Therapy Model

is The First Single Source Reference Demonstrating The Application Of Pharmacogenetics In The Care Of Breast Cancer Patients

enables Physicians A Coherent Interpretation Of The Emerging Science Of Pharmacogenetics, Aiding Them To Incorporate Individual Therapies In Their Own Practice

gives Practical Guidance On Various Forms Of Specimen Collection, Tissue Selection, And Handling Procedures

Pharmacogenetics, generally referred to as the study of genetic variation that gives rise to differing response to drugs, is becoming more relevant in the diagnosis, treatment, and recovery of cancer patients. The problem faced when treating cancer is the outstanding varied efficacy between success and failure. Unpredictability between a population of patients who are affected with the same occurring malignancy can show varying associated toxicities in drug treatment ranging from zero effect through lethal doses. Since the chemotherapeutic agent is often developed to fit the average patient th