Pharmaceutics: The science of medicine design (Integrated Foundations Of Pharmacy)

Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutics: The science of medicine design explores the different forms that medicines can take, and demonstrates how being able to select the best form - be it a tablet, injectable liquid, or an inhaled gas - requires an understanding of how chemicals behave in different physical states. Online Resource Centre The Online Resource Centre to accompany Pharmaceutics: the science of medicine design features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter. Taking Medication Is A Common Occurrence For Many People, Whether It Is To Soothe An Aching Head, Regulate Blood Sugars, Or To Treat Life Threatening Conditions, Such As Hiv Or Cancer. In The Uk Alone, Over 900 Million Prescriptions Are Dispensed Every Year. Overseeing All Of This Are Pharmacists: Experts In Medicines And Their Use. Machine Generated Contents Note: 1. Introduction To Pharmaceutics / Philip Denton -- 1.1. Dosage Forms -- 1.2. Drug Delivery -- 1.3. Choice Of Dosage Form -- 1.4. Why Do I Need To Study Pharmaceutics? -- 1.5. Pharmaceutical Measurements -- 2. Solids / Barbara Conway -- 2.1. Properties Of Solids -- 2.2. Crystalline And Amorphous Solids -- 2.3. Polymorphism -- 2.4. Solubility -- 2.5. Solid Dosage Forms Administered Via The Digestive Tract -- 2.6. Solid Dosage Forms Administered By Other Routes -- 3. Liquids / Matthew Roberts -- 3.1. Structure Of Liquids -- 3.2. Properties Of Static Liquids -- 3.3. Properties Of Flowing Liquids -- 3.4. Types Of Liquids -- 3.5. Liquid Dosage Forms -- 4. Gases / Ben Forbes -- 4.1. Gas Laws -- 4.2. Properties Of Gases -- 4.3. Pharmaceutical Operations And Product Stability -- 4.4. Gaseous Therapy -- 4.5. Gas-based Dosage Forms -- 5. Thermodynamics / Linda Seton -- 5.1. Energetics Of Chemical And Physical Processes -- 5.2. First Law Of Thermodynamics: What Is Possible? -- 5.3. Enthalpy And Hess's Law -- 5.4. Entropy And The Second Law Of Thermodynamics: What Is Permissible? -- 5.5. Gibbs Free Energy -- 5.6. Reactions At Equilibrium -- 6. Acids And Bases / Judith Madden -- 6.1. Acidic And Basic Behaviour -- 6.2. Factors Affecting Acid And Base Strength -- 6.3. Ionic Product Of Water And The Ph Scale -- 6.4. Measuring The Strengths Of Acids And Bases -- 6.5. Ionization Of Acidic And Basic Apis -- 6.6. Buffers -- 7. Phase Equilibria And Transitions / Steve Enoch -- 7.1. Phases, Phase Transitions, And Phase Equilibria -- 7.2. Phase Diagrams For Pure Substances -- 7.3. Solid-liquid Phase Diagrams For Two-component Systems -- 7.4. Solid-liquid Phase Diagrams For Two-component Systems With Complex Formation -- 7.5. Liquid-vapour Phase Diagrams For Two-component Systems -- 7.6. Liquid-liquid Phase Diagrams For Two Component Systems -- 7.7. Phase Diagrams For Three-component Systems -- 8. Hydrophobicity And Partitioning / William Mcauley -- 8.1. Hydrophobicity -- 8.2. Partition Coefficient -- 8.3. Distribution Coefficient -- 8.4. Thermodynamics Of Partitioning -- 8.5. Measuring The Partition Coefficient -- 8.6. Choice Of The Lipophilic Phase -- 8.7. Applications Of Partition Coefficients -- 9. Surface Phenomena / Ali Al-khattawi -- 9.1. Surface And Interfacial Tension -- 9.2. Contact Angle -- 9.3. Spreading Of Liquids -- 9.4. Adsorption -- 9.5. Surfactants -- 9.6. Surface Charge And Zeta Potential -- 9.7. Gibbs Adsorption Isotherm -- 9.8. Measurement Of Surface And Interfacial Tension -- 10. Disperse Systems / Jayne Lawrence -- 10.1. Classifications Of Disperse Systems -- 10.2. Types Of Disperse System -- 10.3. Preparation Of Dispersions -- 10.4. Properties Of Dispersions -- 10.5. Types Of Physical Instability -- 10.6. Physical Stability Of Different Types Of Dispersions -- 10.7. Disperse Systems Used To Deliver Apis -- 10.8. Dlvo Theory -- 11. Colligative Properties / Philip Denton -- 11.1. Colligative Properties Of Solutions -- 11.2. Osmotic Pressure -- 11.3. Tonicity -- 11.4. Osmosis And Liquid Dosage Forms -- 11.5. Osmotic Pump Dosage Forms -- 11.6. Origin Of Colligative Properties -- 12. Kinetics And Drug Stability / Gary Moss -- 12.1. Types Of Reactions -- 12.2. Reaction Rates And Reaction Orders -- 12.3. Factors Affecting The Rate Of Reaction Of Dosage Forms -- 12.4. Temperature And Reaction Rate -- 13. Drug Discovery, Development, And Delivery / Afzal R. Mohammed -- 13.1. Identification Of Candidate Compounds -- 13.2. Optimization Of Lead Compounds -- 13.3. Introduction To Qsar: Optimization Of Lead Compounds -- 13.4. Preformulation Considerations -- 13.5. Routes Of Administration And Associated Dosage Forms -- 13.6. Packaging Considerations For Pharmaceutical Dosage Forms -- 13.7. Clinical Trials For New Medications. Edited By Philip Denton And Chris Rostron. Includes Bibliographical References And Index. Pharmaceutics Contents Pharmaceutics Chapter 1 - 13 Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Chapter 11 Chapter 12 Chapter 13 Pharmaceutics Index Glossary Answers Index