Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form, Second Edition (Drugs and the Pharmaceutical Sciences, 199)

This timely Second Edition reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, and the shift from developing small molecules to the growth of biopharmaceuticals. It meets the need for up-to-date and advanced information for drug preformulation and formulation, and addresses the current trends in the continually evolving pharmaceutical industry. Ideal for practitioners working in the pharmaceutical industry (including R&D scientists, technicians, and managers), as well as undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology, this text addresses: candidate drug selection drug discovery and development preformulation predictions and drug selections product design to commercial dosage form biopharmaceutical support in formulation development and more Preface......Page 8 Contents......Page 10 Contributors......Page 12 1 Introduction and Perspective......Page 14 2 Aiding Candidate Drug Selection: Introduction and Objectives......Page 24 3 Preformulation Investigations using Small Amounts of Compound as an Aid to Candidate Drug Selection and Early Development......Page 30 4 Biopharmaceutical Support in Candidate Drug Selection......Page 142 5 Early Drug Development: Product Design......Page 185 6 Preformulation as an Aid to Product Design in Early Drug Development......Page 201 7 Biopharmaceutical Support in Formulation Development......Page 260 8 Product Optimization......Page 302 9 Parenteral Dosage Forms......Page 338 10 Inhalation Dosage Forms......Page 361 11 Oral Solid Dosage Forms......Page 380 12 Ophthalmic Dosage Forms......Page 444 13 Aqueous Nasal Dosage Forms......Page 469 14 Topical and Transdermal Delivery......Page 488 Index......Page 540 Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, as well as the shift from developing small molecules to the growth of biopharmaceuticals. The book meets the ne