Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form (Drugs and the Pharmaceutical Sciences Book 199)

Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, as well as the shift from developing small molecules to the growth of biopharmaceuticals. The book meets the need for advanced information for drug preformulation and formulation and addresses the current trends in the continually evolving pharmaceutical industry. Topics include: Candidate drug selection Drug discovery and development Preformulation predictions and drug selections Product design to commercial dosage form Biopharmaceutical support in formulation Development The book is ideal for practitioners working in the pharmaceutical arena-including R&D scientists, technicians, and managers-as well as for undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology Preface 7 Contents 9 Contributors 11 1 Introduction and Perspective 12 2 Aiding Candidate Drug Selection: Introduction and Objectives 22 3 Preformulation Investigations using Small Amounts of Compound as an Aid to Candidate Drug Selection and Early Development 28 4 Biopharmaceutical Support in Candidate Drug Selection 140 5 Early Drug Development: Product Design 183 6 Preformulation as an Aid to Product Design in Early Drug Development 199 7 Biopharmaceutical Support in Formulation Development 258 8 Product Optimization 300 9 Parenteral Dosage Forms 336 10 Inhalation Dosage Forms 359 11 Oral Solid Dosage Forms 378 12 Ophthalmic Dosage Forms 442 13 Aqueous Nasal Dosage Forms 467 14 Topical and Transdermal Delivery 486 Index 537 A Practical Guide from Candidate Drug Selection to Commercial Dosage Form This timely Second Edition reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, and the shift from developing small molecules to the growth of biopharmaceuticals. It meets the need for up-to-date and advanced information for drug preformulation and formulation, and addresses the current trends in the continually evolving pharmaceutical industry