Pharmaceutical Chemistry. Volume 2: Drugs and Their Biological Targets 2

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 2 covers neurotransmitters, antihistamines, enzymatic inhibitors and nonsteroidal anti-inflammatory drugs. - Provides a multidisciplinary approach to the field. - Serves the needs of students and researchers. - Includes case studies and practical examples aiming to help readers gain a broader understanding. Prologue 6 Contents 11 1. Acetylcholine 17 2. Noradrenaline 46 3. Dopamine 71 4. Serotonin and reuptake inhibitors of biogenic amines 90 5. Amino acids as neurotransmitters 104 6. Peptides as neurotransmitters: Hypnoanalgesics 122 7. Histamine and antihistaminics 144 8. Enzymatic inhibitors I 178 9. Enzimatic inhibitors II 188 10. Design of drugs acting on transport through biological membranes 200 11. Enzymatic inhibition: Inhibitors of the biosinthesis of the cellular wall 212 12. Enzymatic inhibition: Other antibacterial agents 237 13. Enzymatic inhibition: Inhibitors of biosinthesis of nitrogenated bases 254 Index 273 "This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents"-- Provided by publisher