PET Studies on Amino Acid Metabolism and Protein Synthesis : Proceedings of a Workshop Held in Lyon, France Within the Framework of the European Community Medical and Public Health Research

Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists. Front Matter....Pages i-xiv Cerebral Protein Turnover: Aspects and Problems....Pages 1-17 Determination of Regional Rates of Cerebral Protein Synthesis in Vivo with L-[1- 14 C]Leucine as the Tracer Amino Acid....Pages 19-39 Methionine Metabolism in Rat Brain....Pages 41-52 Protein Synthesis Studies in Rats with Methionine....Pages 53-68 Back Matter....Pages 69-74 Carbon-11 Amino Acids, Labeling and Metabolites....Pages 75-80 Quality Control Aspects in the Preparation of [ 11 C]-Methionine....Pages 81-87 Production of L-[ 18 F]Fluoro Amino Acids for Protein Synthesis: Overview and Recent Developments in Nucleophilic Syntheses....Pages 89-108 Biochemistry and Evaluation of Fluoroamino Acids....Pages 109-131 Back Matter....Pages 131-131 Kinetic Modeling of Fluorotyrosine Uptake....Pages 133-147 Kinetic Modelling of Carbon-11 Labelled Amino-Acids....Pages 149-160 Carbon-11 Labeled Tyrosine as a Probe for Modelling the Protein Synthesis Rate....Pages 161-174 Kinetic Modelling of Carbon-11 Labelled Methionine....Pages 175-182 Approaches to Quantitative Analysis of Amino Acid Transport and Metabolism....Pages 183-196 11 C-Methionine and 82 Rubidium Uptake in Human Brain Tumors: Comparison of Carrier Dependent Blood-Brain Barrier Transport....Pages 197-201 Back Matter....Pages 201-201 Tracers for Clinical Evaluation of Gliomas: A Neurologist’s View....Pages 203-214 PET Studies of Amino Acid Metabolism: Integration in Clinical Routine and Current Research on Intracranial Tumours....Pages 215-221 Uptake of [ 11 C]Methionine in Non-Brain Tumors....Pages 223-225 Utilization of Amino Acid Transport Rates for the Differential Diagnosis of Brain Tumors....Pages 227-236 Use of Amino Acid Uptake and Protein Synthesis Rates for Tumour Diagnosis....Pages 237-241 11 C-methionine Uptake in Brain Tumors Measured by PET: Early Clinical Results....Pages 243-254 Back Matter....Pages 267-268 11 C-Labeled Methionine Uptake in Gliomas: Modification after Therapy and Metabolic Correlations....Pages 255-263 In Vivo Incorporation of Labelled Methionine into Proteins in Brain Tumors....Pages 265-268 Back Matter....Pages 267-268 Back Matter....Pages 269-270