PET/CT in Prostate Cancer (Clinicians’ Guides to Radionuclide Hybrid Imaging)

This pocket book explains the significant and well-documented impact that PET/CT can have on the management of prostate cancer through the provision of high-quality evidence regarding function and structure. Up-to-date information is supplied on the relevance of PET/CT to diagnosis, treatment planning, and therapy, including the emerging role of PET/CT with PSMA. Readers will also find clear explanation of the relation of the clinical and pathological background to imaging and the value of PET/CT compared with conventional radiological imaging. The book will be an excellent asset for referring clinicians, nuclear medicine/radiology physicians, radiographers/technologists, and nurses who routinely work in nuclear medicine and participate in multidisciplinary meetings. It is published within the Springer series Clinicians’ Guides to Radionuclide Hybrid Imaging , which presents contributions from professionals worldwide who share a common purpose in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions. Foreword Preface Acknowledgements Contents Contributors 1: Epidemiology and Clinical Features 1.1 Epidemiology 1.2 Risk Factors 1.3 Clinical Presentation 1.4 Diagnosis 1.5 Staging Procedures and Investigations 1.6 Risk Stratification References 2: Pathology of Prostate Cancer 2.1 Introduction 2.2 Histological Features 2.3 Immunohistochemistry 2.4 Gleason Grading 2.5 Newer Sampling Techniques 2.6 Prognostic Factors 2.7 Molecular Markers References 3: Management of Prostate Cancer 3.1 Localised Prostate Cancer 3.2 Active Surveillance 3.3 External Beam Radiotherapy 3.3.1 Brachytherapy 3.3.2 Radical Prostatectomy 3.4 Metastatic Disease 3.4.1 Corticosteroids 3.4.2 Cytotoxic Chemotherapy 3.4.3 Androgen Receptor Pathway Targeted Agents 3.4.4 Other Agents References 4: Prostate Cancer: Radiological Imaging 4.1 Locoregional Disease 4.1.1 Transrectal Ultrasound 4.1.2 Magnetic Resonance Imaging Morphological Evaluation Diffusion-Weighted MRI Dynamic Contrast-Enhanced MRI MR Spectroscopy 4.1.3 Metastatic Disease 4.1.4 Clinical Guidance Diagnosis Staging Active Surveillance References 5: The Role of PET/CT in Prostate Cancer Management 5.1 Diagnosis of Prostate Malignancies 5.2 Staging of Prostate Malignancies 5.3 Restaging at Disease Recurrence 5.4 Assessing Treatment Response 5.5 Prognostication 5.6 Radiotherapy Planning References 6: Role of Radiolabelled Small Molecules Binding to PSMA in Diagnosis and Therapy of Prostate Cancer 6.1 Diagnostic Application 6.2 Endoradiotherapy References Index