PET chemistry : the driving force in molecular imaging ; with 20 tables ; [62nd Ernst Schering Foundation Workshop PET Chemistry - the Driving Force in Molecular Imaging

The incessant progress in the comprehension of molecular processes of disease formation and progression is accompanied by an increasing importance of biomedical molecular imaging methods. PET, a nuclear medical imaging modality, is ideally suited to produce such kinds of images by use of positron-emitting chemical entities. The purpose of this workshop was to discuss and overview applications and technologies in the area of PET chemistry. The book provides the reader with state-of-the-art information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76, Br-77 and I-124, and their impact on molecular imaging. New technical features such as microwaves, microreactors and modules for the synthesis of new PET tracers are discussed. Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. PET chemistry can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry. Molecular Imaging With Pet -- Open Questions? / P.a. Schubinger -- Fluorine-18 Labeling Methods / H.h. Coenen -- Fluorine-18 Labeling Of Small Molecules / F. Wuest -- Fluorine-18 Labeling Of Peptides And Proteins / H.j. Wester, M. Schottelius -- [18f] Fluoropyridines / F. Dolle -- Production Of Non-standard Pet Radionuclides And The Application Of Radiopharmaceuticals Labeled With These Nuclides / M.h. Welch, R. Laforest, J.s. Lewis -- Carbon-11 Labeling Chemistry Based Upong [11c] Methyl Iodide / F. Wuest, M. Berndt, T. Kniess -- 68ga-pet Radiopharmacy / H.r. Maecke, J.p. Andre -- Microwaving In F-18 Chemistry / S. Stone-elander, N. Elander, J.o. Thorell, A.fredriksson -- Micro-reactors For Pet Tracer Labeling / S.y. Lu, V.w. Pike -- Synthesis Modules And Automation In F-18 Labeling / R. Krasikova -- Pharamcological Prerequisites For Pet Ligands And Practical Issues In Preclinical Pet Research / S.m. Ametamey, M. Honer -- Positron Emission Tomography Imaging As A Key Enabling Technology In Drug Development / T.j. Mccarthy. P.a. Schubiger, L. Lehmann, M. Friebe, Editors. International Conference Proceedings. Includes Bibliographical References. PET, a nuclear medical imaging modality, is ideally suited to produce biomedical molecular images by use of positron-emitting chemical entities. This book provides information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76, Br-77 and I-124, and their impact on molecular imaging