Pertussis toxin: Proc. (in part) of the Pertussis toxin conf. held at the Nat. inst. of health on Sept. 20 a. 21, 1984

Pertussis Toxin presents the proceeding of the Pertussis Toxin Conference, held in Bethesda, Maryland, on September 20–21, 1984. This book discusses the perspective of the pertussis toxin and the potential role of the toxin in the development of new acellular pertussis vaccines. Organized into 13 chapters, this text begins with an overview of the biological activities of pertussis vaccine, which enhanced the production of antibodies to antigens. This book then examines the interesting action of pertussis vaccine to stimulate antibody production, particularly as an effective adjuvant for the production of IgE isotype of antibodies. Other chapters consider the experimental approaches used in the study of the mechanisms by which hormones produce their physiological effect. The final chapter examines the several features of the Bordetella adenylate cyclase toxin, which suggest that the molecule may follow the A/B model proposed for a number of bacterial toxins. This book is a valuable resource for toxicologists, immunologists, bacteriologists, and pharmacologists. Content: Academic Press Rapid Manuscript Reproduction , Page ii Front Matter , Page iii Copyright , Page iv CONTRIBUTORS , Pages vii-ix PREFACE , Pages xi-xii , RONALD D. SEKURA, JOEL MOSS, MARTHA VAUGHAN BIOLOGICAL ACTIVITIES OF PERTUSSIGEN (PERTUSSIS TOXIN) , Pages 1-18 , John J. Munoz ISLET-ACTIVATING PROTEIN, PERTUSSIS TOXIN: SUBUNIT STRUCTURE AND MECHANISM FOR ITS MULTIPLE BIOLOGICAL ACTIONS , Pages 19-43 , Michio Ui, Katsumi Nogimori, Makoto Tamura PERTUSSIS TOXIN: STRUCTURAL ELEMENTS INVOLVED IN THE INTERACTION WITH CELLS , Pages 45-64 , Ronald D. Sekura, Yan-ling Zhang, Marie-Jose Quentin-Millet GTP-REGULATORY PROTEINS ARE INTRACELLULAR MESSENGERS: A MODEL FOR HORMONE ACTION , Pages 65-75 , Martin Rodbell STRUCTURAL AND FUNCTIONAL PROPERTIES OF N S AND N i , THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES , Pages 77-104 , L. Birnbaumer, J. Codina, T. Sunyer, W. Rosenthal, J.D. Hildebrandt, R.A. Cerione, M.G. Caron, R.J. Lefkowitz, R.D. Sekura PERTUSSIS TOXIN-CATALYZED ADP-RIBOSYLATION: EFFECTS ON COUPLING OF INHIBITORY RECEPTORS TO ADENYLATE CYCLASE , Pages 105-128 , Joel Moss, Martha Vaughan, Erik L. Hewlett Resolution of Agonists and Gpp(NH)p Mediated Adenylate Cyclase Inhibition with Pertussis Toxin , Pages 129-147 , Thomas E. Cote, Elizabeth A. Frey, Ronald D. Sekura PERTISSIS TOXIN DISCRIMINATES SOMATOSTATIN'S REGULATION OF ACTH RELEASE THROUGH ADENYLATE CYCLASE AND NON-ADENYLATE CYCLASE MECHANISMS , Pages 149-166 , Terry D. Reisine GENETIC AND FUNCTIONAL STUDIES OF PERTUSSIS TOXIN SUBSRATES , Pages 167-184 , Henry R. Bourne, Daniel Medynski, Cornelis Van Dop, Kathleen Sullivan, Fu-Hsiung Chang BIOCHEMICAL BASIS OF THE ADJUVANT EFFECTS OF PERTUSSIS TOXIN FOR THE IgE RESPONSE , Pages 185-204 , Kimishige Ishizaka, Makoto Iwata, Moriaki Akasaki, Teruko Ishizaka, John J. Munoz EFFECT OF PERTUSSIS TOXIN ON THE HORMONAL RESPONSIVENESS OF DIFFERENT TISSUES , Pages 205-223 , J. Adolfo García-Sáinz EXTRACELLULAR ADENYLATE CYCLASE OF BOROETELLA PERTUSSIS , Pages 225-239 , J. Wolff BORDETELLA ADENYLATE CYCLASE TOXIN: ITS INTOXICATION OF MAMMALIAN CELLS AND EFFECTS ON CELL FUNCTION , Pages 241-250 , Erik L. Hewlett, Alison A. Weiss, Richard D. Pearson, Gwendolyn A. Myers, Michael J. Cronin INDEX , Pages 251-255