Perspectives in Translational Research in Life Sciences and Biomedicine : Translational Outcomes Research in Life Sciences and Translational Medicine, Volume 1

The present book addresses the multi-disciplinary nature of Translational Outcomes Research, which is a watershed for nearly all the disciplines of Life and Health Sciences, along with the Materials Sciences including but not limited to Zoology, Botany, Microbiology, Biochemistry, Physiology, Nanotechnology, the Medical Sciences, Bioengineering, Biophysics, Medicinal Chemistry, Structural Biology, Biostatistics and Bioinformatics. This book, for the first time, addresses the basic premises of fundamental research in facilitating drug discovery. One chapter is dedicated to a novel generation of platforms with novel camelid antibodies and their technological extensions, while another focuses on functional food and nutraceuticals. The book begins with a thorough overview of what translational outcomes research connotes and what the current status of research in the area is, and goes on to elucidate various pertinent preclinical disease models and their uses in basic and application based research in the Life Sciences. How basic approaches to screening and characterization vis-à-vis their role in amelioration of the two cardinal problems of inflammation and degeneration involved in most diseases is elucidated. The book ends with a discussion of the relevance and importance of using Bio Green technology in Translational Outcomes, addressing the need to fill the gap between academia and industry and clinics that can arise through direct or indirect collaboration between the stakeholders and emphasizing the need for an eco-friendly approach so as not to jeopardize the fine balance that holds life on earth in harmony. Front Matter ....Pages i-xii Translational Research in Life Sciences (Ena Ray Banerjee)....Pages 1-10 Front Matter ....Pages 11-11 Idiopathic Lung Fibrosis Model for Drug Discovery (Ena Ray Banerjee)....Pages 13-31 Aseptic Peritonitis Model for Drug Discovery (As Therapy) (Ena Ray Banerjee)....Pages 33-50 Aseptic Peritonitis Model for Drug Discovery (for Prophylaxis) (Ena Ray Banerjee)....Pages 51-75 Dissecting Key Cellular Players Regulating Pathophysiology of Acute and Chronic Allergic Asthma (Ena Ray Banerjee)....Pages 77-87 Dissecting Asthma Pathogenesis Through Study of Patterns of Cellular Traffic Indicative of Molecular Switches Operative in Inflammation (Ena Ray Banerjee)....Pages 89-117 Drosophila Stem Cell Niches—Studies in Developmental Biology (Ena Ray Banerjee)....Pages 119-127 Front Matter ....Pages 129-129 Camelid Antibody-Based Therapeutics for Animal and Human Health (Ena Ray Banerjee)....Pages 131-151 Development of a Novel Format of Stable Single Chain Antibodies Against Staphylococcus aureus and Allergen-Specific IgE in Allergic Asthma (Ena Ray Banerjee)....Pages 153-167 Development of a Novel Format of Stable Single-Chain Antibodies Against Alkaline Phosphatase as Therapeutic Molecules (Ena Ray Banerjee)....Pages 169-181 Development of a Novel Format of Stable Single-Chain Antibodies Against Alpha Amylase as Therapeutic Molecules (Ena Ray Banerjee)....Pages 183-186 Figures of Quantifiable Data in Support of Achieved Goals (Ena Ray Banerjee)....Pages 187-194 Front Matter ....Pages 195-195 Subchapter-A (Ena Ray Banerjee)....Pages 197-203 Subchapter-B (Ena Ray Banerjee)....Pages 205-232 Subchapter-C: Translational Outcome Research with Date Extracts as Functional Food in Diseases Involving Oxi-Flammatory Pathways. (Ena Ray Banerjee)....Pages 233-262 Front Matter ....Pages 263-263 Nanomedicine: Nanoparticles and Its Relevance in Drug Discovery vis-a-vis Biomedicine (Ena Ray Banerjee)....Pages 265-270