Perspectives in inflammation : future trends and developments : the proceedings of the third international meeting on future trends in inflammation, held in London, February 14th-18th, 1977

This report on Future Trends in Inflammation III is the record of what is now firmly established as a series of multidisciplinary meetings organized by the European Biological Research Association. The aim of these meetings is to provide a forum for free exchange of information between basic scien­ tists of many disciplines and clinicians to provide better understanding of problems of common interest. The next major meeting wi1l be held in 1980.\* The European Biological Research Association promotes scientific and clinical collaboration among the member countries ofthe EEe. It encourages exchange of information between scientists and clinicians from centres all over the world. In addition to the major international meetings small work­ shops are organized on specific problems of common interest. Once again the Editors have attempted to capture the spirit of the meeting by publishing 'verbatim' the discussion. It can be seen that the discussions were exciting and formed an important part of the meeting. It is possible that inaccuracies have crept into the discussions; if so we apologize. It was decided that the proceedings of such a meeting had maximum value with rapid publication. We would like to thank the participants for the enthusiasm and goodwill which persisted throughout the meeting both scientifically and socially. Above all we wish to thank H.R.H. The Duchess of Kent for acting as Patron of this meeting. Front Matter....Pages i-xxi Front Matter....Pages 1-10 The rationale of using levamisole in the treatment of rheumatoid arthritis....Pages 11-20 Immunostimulation, levamisole and rheumatoid arthritis....Pages 21-27 The effect of cytotoxic drugs on the formation of mononuclear phagocytes....Pages 29-37 Rheumatoid factor-immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation....Pages 39-48 Front Matter....Pages 61-67 A model for assessing effects of drugs on granulocyte emigration in vivo ....Pages 69-74 A polymorph abnormality in Crohn’s disease....Pages 75-79 The origin and kinetics of liver macrophages during steady state and inflammation ( Abstract )....Pages 81-83 Lymphocyte-mediated eosinophilia in guinea pigs with delayed hypersensitivity to a chemical....Pages 85-100 A role for L-lymphocytes in chronic inflammation....Pages 101-113 Cartilage degradation by macrophages, fibroblasts and synovial cells in culture. An in vitro model suitable for studies on rheumatoid arthritis....Pages 115-129 Adjuvant arthritis: immune responses and effects of Tilorone or interferon in partially suppressing the disease....Pages 131-146 Front Matter....Pages 161-167 The effect of local elevation of leukocyte cyclic AMP content on lysosomal enzyme release during acute inflammation in vivo ....Pages 169-178 Recent studies on the secretory activity of mononuclear phagocytes with special reference to prostaglandins....Pages 179-189 Interactions of macrophages and complement components in the pathogenesis of chronic inflammation....Pages 191-209 Matrix vesicles and apatite nodules in arthritic cartilage....Pages 211-223 Crystal induced inflammation and osteoarthritis....Pages 225-231 Microanalysis of particulate material involved in inflammation....Pages 233-237 The influence of chemical composition of plasma membranes on the functional activities of macrophages....Pages 239-250 Front Matter....Pages 263-263 Dual function of E-type prostaglandins in models of chronic inflammation....Pages 265-277 Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease....Pages 279-288 Front Matter....Pages 263-263 The time course of the vascular events associated with inflammation due to ultraviolet irradiation of guinea pig ears....Pages 289-294 Role of macrophages in D-penicillamine-induced stimulation of DNA synthesis in lymph node cells....Pages 295-302 Anti-inflammatory effects of tumour bearing....Pages 303-316 Role of platelets and of prostaglandin synthetase on hypotensive effects of arachidonic acid and of carrageenan....Pages 317-330 Evidence for a pivotal role of the endoperoxide, PGG 2 , in inflammatory processes....Pages 331-337 Thiols and prostaglandin biosynthesis....Pages 339-345 Interactions of non-steroidal anti-inflammatory drugs with substance P-like and gastrointestinal hormones-like polypeptides....Pages 347-352 Salicylic acid and proquazone: the differences in absorption and biodistribution explain their different profile of side-effects....Pages 353-360 Degradation of bovine nasal cartilage by a neutral protease from human leukocyte granules....Pages 361-370 Inhibition of experimental ocular inflammation by topical application of non-steroidal anti-inflammatory drugs (NSAID)....Pages 371-381 Potentiation of acenocoumarin-induced anticoagulation by a new anti-inflammatory agent in man (Abstract) ....Pages 383-385 In vitro methods for assessing anti-inflammatory drug activity (Abstract) ....Pages 387-389 Front Matter....Pages 391-391 Potentiation of antibody formation by proteases in vivo ....Pages 393-398 Triggers of prostaglandin release from macrophages....Pages 399-404 Biological, chemical and pharmacological induction of the properdin-mediated pathway of complement activation in vitro ....Pages 405-416 Immune reactions of lymphocytes eluted from rheumatoid inflammatory tissue....Pages 419-426 Attempts at producing immune complexes in vitro between isolated macroglobulins and purified IgGs....Pages 427-434 Behaviour of some inflammation parameters in plasma and synovial fluid in some rheumatic diseases ( Abstract )....Pages 435-436 Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systemic acute-phase reaction of the rat....Pages 437-444 Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E....Pages 445-454 Front Matter....Pages 391-391 Rheumatoid-like joint lesions in rabbits injected intravenously with foreign serum....Pages 455-459 Anti-inflammatory activity of some bacterial immunostimulants. Relation with macrophage migration....Pages 461-468 Inflammatory exudates and mitogenic activity....Pages 469-479 Secretory activity of epithelioid cells....Pages 481-490 Vascular changes during acute inflammatory responses in rat hindpaws....Pages 491-495 Front Matter....Pages 497-497 Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation....Pages 499-505 Relationships between increased vascular permeability, oedema, hyperalgesia and the effect of non-steroid anti-inflammatory drugs....Pages 507-518 Two sites of action of steroids on the prostaglandin system....Pages 519-525 Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein)....Pages 527-544 Humoral control of monocytopoiesis ( Abstract )....Pages 545-547 Front Matter....Pages 557-560 Difficulties in the clinical evaluation of new anti-inflammatory drugs....Pages 561-573 Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?....Pages 575-583 About immunological anomalies in treated and non-treated rheumatoid arthritis: rosette test and immunofluorescence of B-cells....Pages 585-590 Should penicillamine be prescribed for rheumatoid arthritis?....Pages 591-597 Long-term evaluation of intermittent levamisole treatment in rheumatoid arthritis....Pages 599-609 Back Matter....Pages 619-638