Personalized Medicine with a Nanochemistry Twist: Nanomedicine (Topics in Medicinal Chemistry Book 20)

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation --Huei-Huei Chang, Shaneen Braswell, Jonathan George, Mark Gryka, Sumin Kim, Nicolas Kolmodin, Manu Kumar, Benjamin Seadler, Oluwayemisi Sonoiki, and Dipanjan Pan Nanoscopic Agents in a Physiological Environment: The Importance of Understanding Their Characteristics --Victoria Sherwood, Desirè Di Silvio, and Francesca Baldelli Bombelli Rational Design of Multifunctional Nanoscale Self-Assembled Soft Materials for Biomedical Delivery Application --Shrinivas Venkataraman Multimodal Imaging and Theranostic Application of Disease-Directed Agents --Joseph Caffarini, Nathan Kelleher, Christian C. Konopka, Madeline Mazurek, Anuradha Nandyala, Dwani Patel, Stephanie Slania, Sheryl Wang, Ravi Chandra Yada, and Dipanjan Pan Nano-Enabled Delivery of Intracellular Therapeutics -- Fatemeh Ostadhossein, Enrique Alejandro Daza, Daniel Frankowski, Drew Goatz, Molly Imgruet, Joseph Kus, Ryan Lake, Mallika Modak, Nick Olsen, Aaron Schwartz-Duval, Alyssa Zimmer, Nicholas Kolmodin and Dipanjan Pan Personalized Medicine: Where Do We Go from Here?--Dipanjan Pan Front Matter....Pages i-vii Barriers in Nanomedicine: The Importance of Defined Chemistry and Engineering Approaches for Clinical Translation....Pages 1-27 Nanoscopic Agents in a Physiological Environment: The Importance of Understanding Their Characteristics....Pages 29-54 Rational Design of Multifunctional Nanoscale Self-Assembled Soft Materials for Biomedical Delivery Application....Pages 55-73 Multimodal Imaging and Theranostic Application of Disease-Directed Agents....Pages 75-103 Nano-Enabled Delivery of Intracellular Therapeutics....Pages 105-119 Personalized Medicine: Where Do We Go from Here?....Pages 121-130 Back Matter....Pages 131-133