Peripheral Receptor Targets for Analgesia : Novel Approaches to Pain Management

Content: Chapter 1 Role of Peripheral Mechanisms in Craniofacial Pain Conditions (pages 1–20): Barry J. SessleChapter 2 Role of Peripheral Mechanisms in Spinal Pain Conditions (pages 21–40): Brian E. Cairns and Pradit PrateepavanichChapter 3 Voltage?Gated Sodium Channels in Peripheral Nociceptive Neurons as Targets for the Treatment of Pain (pages 41–91): Theodore R. CumminsChapter 4 Potassium Channels (pages 93–110): Daisuke Nishizawa, Toru Kobayashi and Kazutaka IkedaChapter 5 Voltage?Gated Calcium Channels as Targets for the Treatment of Chronic Pain (pages 111–136): Joseph G. McGivernChapter 6 Adenosine Receptors (pages 137–152): Jana SawynokChapter 7 Acid?Sensing Ion Channels and Pain (pages 153–174): Roxanne Y. Walder, Christopher J. Benson and Kathleen A. SlukaChapter 8 Vanilloid (TRPV1) and Other Transient Receptor Potential Channels (pages 175–213): Marcello Trevisani and Arpad SzallasiChapter 9 Glutamate Receptors (pages 215–241): Brian E. CairnsChapter 10 Serotonin Receptors (pages 243–274): Malin ErnbergChapter 11 Adrenergic Receptors (pages 275–296): Antti PertovaaraChapter 12 Cholinergic Receptors and Botulinum Toxin (pages 297–324): Parisa GazeraniChapter 13 Cannabinoids and Pain Control in the Periphery (pages 325–345): Jason J. McDougallChapter 14 Opioid Receptors (pages 347–372): Claudia Herrera Tambeli, Luana Fischer and Carlos Amilcar ParadaChapter 15 Calcitonin Gene?Related Peptide and Substance P (pages 373–396): Ranjinidevi Ambalavanar and Dean DessemChapter 16 Role of Somatostatin and Somatostatin Receptors in Pain (pages 397–417): Ujendra KumarChapter 17 Cytokines (Tumor Necrosis Factor, Interleukins) and Prostaglandins (pages 419–454): Per AlstergrenChapter 18 Neurotrophic Factors and Pain (pages 455–472): Peter SvenssonChapter 19 Topical and Systemic Drug Delivery Systems for Targeted Therapy (pages 473–514): Urs O. Hafeli and Amit KaleChapter 20 Gene Therapy for Pain (pages 515–528): Marina Mata and David J. FinkChapter 21 Topical Analgesics (pages 529–535): Akhlaq Waheed Hakim and Brian E. Cairns

A unique reference on peripheral pain receptor mechanisms

While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain.

A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics.

Coverage includes:

• The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system
• Novel delivery techniques
• An appendix listing currently available topical analgesic medications
• A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University

An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.

Role of peripheral mechanisms in craniofacial pain conditions / Barry J. Sessle Role of peripheral mechanisms in spinal pain conditions / Brian E. Cairns & Pradit Prateepavanich Voltage-gated sodium channels in peripheral nociceptive neurons as targets for the treatment of pain / Theodore R. Cummins Potassium channels / Daisuke Nishizawa1, Toru Kobayashi, & Kazutaka Ikeda Voltage-gated calcium channels as targets for the treatment of chronic pain / Joe McGivern Adenosine receptors / Jana Sawynok Acid-sensing ion channels and pain / Roxanne Y. Walder, Christopher J. Benson & Kathleen A. Sluka Vanilloid (TRPV1) and other transient receptor potential channels / Marcello Trevisani & Arpad Szallasi Glutamate receptors / Brian E. Cairns Serotonin receptors / Malin Ernberg Adrenergic receptors / Antti Pertovaara Cholinergic receptors and botulinum toxin / Parisa Gazerani Cannabinoids and pain control in the periphery / Jason J. McDougall Opioid receptors / Claudia Herrera Tambeli, Luana Fischer & Carlos Amilcar Parada Calcitonin gene-related peptide and substance P / Ranjinidevi Ambalavanar & Dean Dessem Role of somatostatin and somatostatin receptors in pain / Ujendra Kumar Cytokines (tumor necrosis factor, interleukins) and prostaglandins / Per Alstergren Neurotrophic factors and pain / Peter Svensson Topical and systemic dosage forms for targeted drug delivery / Urs Hafeli & Amit Kale Gene therapy for pain / Marina Mata & David J. Fink Topical analgesics / Akhlaq Waheed Hakim & Brian E. Cairns. A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system Novel delivery techniques An appendix listing currently available topical analgesic medications A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference. While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, this book provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system; Novel delivery techniques; An appendix listing currently available topical analgesic medications; A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University. An unmatched resource for improving drug therapies and making pain management more efficient Peripheral Receptor Targets for Analgesia. Novel Approaches to Pain Management. Edited by. Brian E. Cairns. A unique reference on peripheral pain receptor mechanisms. While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesi