Penicillins and Cephalosporins, Vol. 1 (Chemistry and Biology of B-Lactam Antibiotics)

Chemistry and Biology of?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the?-lactam moiety. This book discusses the occurrence of a group of?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists. Content: Inside Front Cover, Page ii Front Matter, Page iii Copyright, Page iv Dedication, Pages v-vii Contributors, Page xiii Preface, Pages xv-xx, Marvin Gorman, Robert B. Morin Introduction, Pages xxi-xxxviii, E.P. Abraham Contents of Other Volumes, Pages xxxix-xl 1 - The Chemistry of Penicillin Sulfoxide, Pages 1-92, ROBIN D.G. COOPER, GARY A. KOPPEL 2 - Cephalosporin Antibiotics Prepared by Modifications at the C-3 Position, Pages 93-198, STJEPAN KUKOLJA, ROBERT R. CHAUVETTE 3 - Cephamycin Antibiotics, Pages 199-370, ERIC M. GORDON, RICHARD B. SYKES 4 - Antimicrobial and Pharmacokinetic Properties of Newer Penicillins and Cephalosporins, Pages 371-436, J.A. WEBBER, W.J. WHEELER 5 - Theoretical and Physicochemical Studies on β-Lactam Antibiotics, Pages 437-545, DONALD B. BOYD Index, Pages 547-553