Pediatric and Adolescent Osteosarcoma (Cancer Treatment and Research Book 152)

Pediatric and Adolescent Osteosarcoma provides a review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in epidemiology and etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age groups, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome. In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments. "Osteosarcoma is the most common primary bone malignancy. Remarkable advances have occurred in the management of this cancer over the last two decades. In this text experts in the field discuss the most pertinent biologic and clinical issues relevant to the disease." Steven T. Rosen, M.D. Series Editor General Aspects Of Osteosarcoma -- Epidemiology Of Osteosarcoma / Giula Ottaviani, Norman Jaffe -- Etiology Of Osteosarcoma / Guilia Ottaviani, Norman Jaffe -- Imaging Assessment Of Osteosarcoma In Childhood And Adolescence: Diagnosis, Staging, And Evaluating Response To Chemotherapy / Farzin Eftekhari -- Osteosarcoma Multidisciplinary Approach To The Management From The Pathologist's Perspective / A. Kevin Raymond, Norman Jaffe -- Conditions That Mmic Osteosarcoma / A. Kevin Raymond, Norman Jaffe -- Treatment -- Surgical Management Of Primary Osteosarcoma / Alan W. Yasko. Role Of Radiotherapy In Osteosarcoma / Rudolf Schwarz, Oyvind Bruland, Anna Cassoni, Paula Schombert, Stefan Bielack -- Osteosarcoma Lung Metastases Detection And Principles Of Multimodal Therapy / Dorothe Carrle, Stefan Bielack -- Surgical Treatment Of Pulmonary Metastases From Osteosarcoma In Pediatri And Adolescent Patients / Matthew Steliga, Ara Vaporciyan -- Non-surgical Treatment Of Pulmonary And Extra-pulmonary Metastases / Peter Anderson -- Review Of The Past, Impact On The Future -- Adjuvant Chemotherapy In Osteosarcoma: An Odyssey Of Rejection And Vindication / Norman Jaffe. Osteosarcoma: Review Of The Past, Impact On The Future. The American Experience / Norma Jaffe -- Osteosarcoma: The European Osteosarcoma Intergroup (eoi) Perspective / Alan W. Craft -- Treatment Of Non-metastatic High Grade Osteosarcoma Of The Extremity: Review Of The Italian Rizzoli Experience. Impact On The Future / Stefano Ferrari, Emanuela Palmerini, Eric L. Staals, Mario Mercuri, Bertoni Franco, Piero Picci, Gaetano Bacci -- Osteosarcoma: The Coos Experience / Stefan Bielack, Herbert Jurgens, Gernot Jundt, Matthias Kevric, Thomas Kuhne, Peter Rechardt, Andreas Zoubek, Mathias Werner, Winfried Winkelmann, Rainer Kotz -- Treatment Of Osteosarcoma. The Scandinavian Sarcoma Group Experience / Oyvid S. Bruland, Henrik Bauer, Thor Alvegaard, Sigbjorn Smeland -- Childhood Osteosarcoma: Multimodal Therapy In A Single-institution Turkish Series / Inci Ayan, Rejin Kebudi, Harzem Ozger -- International Collaboration Is Feasible In Trials For Rare Conditions: The Euramas Experience / N. Marina, S. Bielack, J. Whelan, S. Smeland, M. Karilo, M.r. Sydes, T. Butterfass-bahloul, G. Calaminus, M. Bernstein Cont -- Pediatric And Adult Osteosarcoma: Comparisons And Contrasts In Presentation And Therapy / Robert S. Benjamin And Shreyaskumar R. Patel. Supportive Care And Quality Of Life -- Role Of Physical Therapy And Occupational Therapy In The Rehabilitation Of Pediatric And Adolescent Patients With Osteosarcoma / Marissa Punzalan, Gayle Hyden -- Caring For Children And Adolescents With Osteosarcoma: A Nursing Perspective / Margaret Pearson -- Prosthetics For Pediatric And Adolescent Amputees / Ted B. Muilenburg -- Functional, Psychosocial And Professional Outcomes In Long-term Survivors Of Lower-extremity Osteosarcomas: Amputation Versus Limb Salvage / Giulia Ottaviani, Rhonda S. Robert, Winston W. Huh, Norman Jaffe. Research And Investigation: New And Innovative Strategies -- Bridging The Gap Between Experimental Animals And Humans With Osteosarcoma / Stephen J. Withrow, Chand Khanna -- Is There A Role For Immunotherapy In Osteosarcoma? / David M. Loeb -- Molecular Classification Of Osteosarcoma / Ching C. Lau -- Current Concepts On The Molecular Biology Of Osteosarcoma / Richard Gorlick -- How The Notch Pathway Contributes To The Ability Of Osteosarcoma Cells To Metastasize / Dennis P.m. Hughes. Role Of Fas/fasl In The Metastatic Potential Of Osteosarcoma And Targeting This Pathway For The Treatment Of Osteosarcoma Lung Metastases / Nancy Gordon, Eugenie S. Kleinerman -- Bone Marrow Micrometastases Studied By An Immunomagnet Isolation Procedure In Extremity Localized Non-metastatic Osteosarcoma Patients / Oyvind S. Bruland, Hanne Hoifodt, Kirsten Sundby Hall, Sigbjorn Smeland, Oystein Fodstad -- Strategies To Explore New Approaches In The Investigation And Treament Of Osteosarcoma / Su Young Kim, Lee J. Helman -- History Of Orthopedic Oncology In The United States: Progress From The Past, Prospects For The Future / Williaim F. Enneking -- Editorial Summation. Edited By Norman Jaffe, Øyvind S. Bruland, Stefan S. Bielack. Includes Bibliographical References And Index. Front Matter....Pages i-xx Front Matter....Pages 1-1 The Epidemiology of Osteosarcoma....Pages 3-13 The Etiology of Osteosarcoma....Pages 15-32 Imaging Assessment of Osteosarcoma in Childhood and Adolescence: Diagnosis, Staging, and Evaluating Response to Chemotherapy....Pages 33-62 Osteosarcoma Multidisciplinary Approach to the Management from the Pathologist’s Perspective....Pages 63-84 Conditions that Mimic Osteosarcoma....Pages 85-121 Front Matter....Pages 124-124 Surgical Management of Primary Osteosarcoma....Pages 125-145 The Role of Radiotherapy in Oseosarcoma....Pages 147-164 Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy....Pages 165-184 Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients....Pages 185-201 Non-Surgical Treatment of Pulmonary and Extra-pulmonary Metastases....Pages 203-215 Front Matter....Pages 218-218 Adjuvant Chemotherapy in Osteosarcoma....Pages 219-237 Osteosarcoma: Review of the Past, Impact on the Future. The American Experience....Pages 239-262 Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective....Pages 263-274 The Treatment of Nonmetastatic High Grade Osteosarcoma of the Extremity: Review of the Italian Rizzoli Experience. Impact on the Future....Pages 275-287 Osteosarcoma: The COSS Experience....Pages 289-308 Treatment of Osteosarcoma. The Scandinavian Sarcoma Group Experience....Pages 309-318 Childhood Osteosarcoma: Multimodal Therapy in a Single-Institution Turkish Series....Pages 319-338 International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience....Pages 339-353 Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy....Pages 355-363 Front Matter....Pages 366-366 The Role of Physical Therapy and Occupational Therapy in the Rehabilitation of Pediatric and Adolescent Patients with Osteosarcoma....Pages 367-384 Front Matter....Pages 366-366 Caring for Children and Adolescents with Osteosarcoma: A Nursing Perspective....Pages 385-394 Prosthetics for Pediatric and Adolescent Amputees....Pages 395-420 Functional, Psychosocial and Professional Outcomes in Long-Term Survivors of Lower-Extremity Osteosarcomas: Amputation Versus Limb Salvage....Pages 421-436 Front Matter....Pages 438-438 Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma....Pages 439-446 Is There a Role for Immunotherapy in Osteosarcoma?....Pages 447-457 Molecular Classification of Osteosarcoma....Pages 459-465 Current Concepts on the Molecular Biology of Osteosarcoma....Pages 467-478 How the NOTCH Pathway Contributes to the Ability of Osteosarcoma Cells to Metastasize....Pages 479-496 The Role of Fas/FasL in the Metastatic Potential of Osteosarcoma and Targeting this Pathway for the Treatment of Osteosarcoma Lung Metastases....Pages 497-508 Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients....Pages 509-515 Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma....Pages 517-528 History of Orthopedic Oncology in the United States....Pages 529-571 Back Matter....Pages 573-591 Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome. In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments. Offers a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. This book outlines concepts in Epidemiology and Etiology