Pathogenesis and clinical practice in gastroenterology proceedings of the Falk Symposium 160 held in Portoro�z, Slovenia, June 15-16, 2007 Pathogenesis and clinical practice in gastroenterology : proceedings of the Falk Symposium 160 held in Portorož, Sl

The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled ‘Pathogenesis and Clinical Practice in Gastroenterology’, held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection - endoscopically or via molecular markers - are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents - approved or on the horizon of early clinical studies - will dramatically change the options of patients with chronic disease such as Crohn’s disease, viral hepatitis or hepatocellular carcinoma. Front Matter....Pages i-xv Front Matter....Pages 1-1 Physiology of swallowing and antireflux mechanisms: anything new from a radiologist’s view?....Pages 3-6 Oropharyngeal dysphagia, achalasia, and other oesophageal motility problems: clinical relevance and management....Pages 7-16 Outcomes of different treatment opproaches for gastro-oesophageal reflux disease....Pages 17-27 Barrett’s oesophagus: screening, surveillance, treatment: are all questions answered?....Pages 28-29 Front Matter....Pages 31-31 Helicobacter pylori infection: diagnosis, treatment and risks of untreated infection....Pages 33-40 Front Matter....Pages 41-41 Genetics, Immunology and biomarkers in clinical practice: do they assist in clinical management?....Pages 43-75 Standard therapy for ulcerative colitis and Crohn’s disease: the ECCO guidelines....Pages 76-89 Biologics, novel therapeutic alternatives in inflammatory bowel disease....Pages 90-94 Front Matter....Pages 95-95 Recent advances in coeliac disease....Pages 97-109 Gastrointestinal manlfestations of AIDS....Pages 110-112 Prevention and screening for colorectal cancer....Pages 113-117 Lymphomas of the gastrointestinal tract....Pages 118-123 Front Matter....Pages 125-125 Do we still need liver biopsies?....Pages 127-136 Inflammation and human cancer....Pages 137-146 Front Matter....Pages 147-147 New insights in the immunology of viral hepatitis B and C....Pages 149-160 New aspects of treatment of chronic hepatitis C....Pages 161-168 Front Matter....Pages 169-169 Non-alcoholic steatohepatitis: metabolic syndrome of the liver....Pages 171-185 Autoimmune hepatitis....Pages 186-190 Immunology of primary biliary cirrhosis and primary sclerosing cholangitis....Pages 191-207 Alcoholic hepatitis....Pages 208-217 Front Matter....Pages 219-219 Hepatorenal syndrome in cirrhosis....Pages 221-232 Variceal bleeding....Pages 233-238 Surveillance and prevention of hepatocellular carcinoma....Pages 239-251 Algorithms of diagnosis and options of hepatocellular carcinoma therapy....Pages 252-265 Surgical therapy of liver cancer: resection and transplantation....Pages 266-274 Back Matter....Pages 275-280