Pathobiology of Cancer Regimen-Related Toxicities [recurso electrónico

The contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treatment success and physiological cost. In the second segment of the book, the most current thinking around the pathobiology of specific, common, and representative toxicities is presented by leading researchers and translational scientists. The final portion of the book discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions. Toxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens. In addition to the potential for toxicities to devastate patients' quality of life, they generate huge incremental financial costs, and sap patients' ability to tolerate definitive cancer therapy. And every new drug or biological has come with new side effects. Historically, regimen-related toxicities were viewed as the inevitable cost of treating cancer. But this may be about to change. Discoveries in the past dozen years have painted a new picture of the pathobiology of almost all regimen-related toxicities. The mechanistic complexities that underlie radiation- and chemotherapy-induced tissue injury or systemic symptoms have been pieced together in an incremental sequence which now provides multiple targets for effective toxicity interventions. This book brings together, for the first time in a single volume, the most current information regarding both general principles guiding current thinking about the pathogenesis of regimen-related toxicities and the specific biological underpinnings of the most common side effects of cancer therapy. The contents provide information that is essential to clinicians and basic and translational scientists interested in cancer therapy and its toxicities Front Matter....Pages i-x Front Matter....Pages 1-1 Epidemiology and Outcomes of Regimen-Related Toxicities....Pages 3-17 The Biological Basis for Differences in Normal Tissue Response to Radiation Therapy and Strategies to Establish Predictive Assays for Individual Complication Risk....Pages 19-33 The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance....Pages 35-61 The Role of Genes on the Metabolism of Chemotherapeutic Agents and Their Impact on Toxicity....Pages 63-73 Animal Models of Regimen-Related Toxicities....Pages 75-95 Front Matter....Pages 97-97 Nausea and Vomiting....Pages 99-119 Mucositis....Pages 121-146 Dermatitis and Alopecia....Pages 147-166 Fibrosis....Pages 167-186 Myelosuppression....Pages 187-205 Neuropathy....Pages 207-215 Mechanisms of Cancer Related Fatigue....Pages 217-232 Xerostomia....Pages 233-248 Osteonecrosis....Pages 249-282 Front Matter....Pages 283-283 Conclusion....Pages 285-286 Back Matter....Pages 287-292 Toxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens. In addition to the potential for toxicities to devastate patients quality of life, they enerate huge incremental financial costs, and sap patientes' ability to tolerate definitive cancer therapy.-- Source other than Library of Congress