Pasteurella multocida: Molecular Biology, Toxins and Infection (Current Topics in Microbiology and Immunology Book 361)

This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host tissues, cells, immune system, and signalling pathways. It is more than 125 years since Louis Pasteur identified as the causative agent of "choléra des poules" the bacterium that now bears his name. Since that time, Pasteurella multocida has been recognized as the causative agent of a wide range of infections in a wide range of animal species as well as in humans. Indeed, the species name multocida could be literally translated as "multi-killer". The term pasteurellosis is now widely applied to describe infections of mammals and birds caused by P. multocida. It is therefore surprising that a detailed knowledge of the cellular and molecular basis for pathogenesis in pasteurellosis lags behind what has been elucidated for many other bacterial species. In particular, the molecular basis for host predilection remains completely unknown. This volume brings together contributions from experts in the field of Pasteurella research. It covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of Pasteurella multocida toxin and its interaction with host tissues, cells, immune system, and signalling pathways Pasteurella Multocida : Diseases And Pathogenesis / I. W. Wilkie ... [et Al.] -- Pathogenomics Of Pastuerella Multocida / J. D. Boyce ... [et Al.] -- The Key Surface Components Of Pastuerella Multocida : Capsule And Lipopolysaccharide / Marina Harper, John D. Boyce And Ben Adler -- Pasteurella Multocida And Immune Cells / Katharina F. Kubatzky -- Molecular Biology Of Pasteurella Multocida Toxin / Joachim H. C. Orth And Klaus Aktories -- Pasteurella Multocida Toxin Interaction With Host Cells : Entry And Cellular Effects / Brenda A. Wilson And Mengfei Ho -- Swine Atrophic Rhinitis Caused By Pasteurella Multocida Toxin And Bordetella Dermonecrotic Toxin / Yasuhiko Horiguchi -- The Pasteurella Multocida Toxin : A New Paradigm For The Link Between Bacterial Infection And Cancer / Alistair Lax. Klaus Aktories, Joachim H.c. Orth, Ben Adler, Editors. Includes Bibliographical References And Index. Front Matter....Pages i-x Pasteurella multocida : Diseases and Pathogenesis....Pages 1-22 Pathogenomics of Pasteurella multocida ....Pages 23-38 The Key Surface Components of Pasteurella multocida : Capsule and Lipopolysaccharide....Pages 39-51 Pasteurella multocida and Immune Cells....Pages 53-72 Molecular Biology of Pasteurella multocida Toxin....Pages 73-92 Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects....Pages 93-111 Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin....Pages 113-129 The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer....Pages 131-144 Back Matter....Pages 145-147