Parkinson's disease and movement disorders: diagnosis and treatment guidelines for the practicing physician / edited by Charles H. Adler and J. Eric Ahlskog

With the rapid expansion of research on the pathogenesis of movement disorders, the growing availability of novel medical and surgical treatment options for Parkinson's disease, and the increasing prevalence of such disorders in an aging population, physicians face an especially difficult task in keeping their practices up-to-date. In Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician, highly experienced clinician-researchers distill this immense amount of new information to create a practice-oriented tutorial for all nonspecialists treating movement disorders. Their book helps physicians to distinguish each disorder, providing a basic understanding of both the test and treatment options needed in active practices, as well as the effective use of the therapeutic recommendations of consulting specialists. The first half of the book is devoted to Parkinson's disease and conditions masquerading as parkinsonism, while the remainder details the recognition and treatment of tremor, dystonia, chorea, myoclonus, tics, gait disorders, restless legs syndrome, the ataxias, conditions resulting in spasms, and the use of botulinum toxin in movement disorders. In all cases the book provides sufficient background so that even relatively inexperienced clinicians can readily master the diagnosis and treatment of these neurologic conditions. Concise, informative, and eminently practical, Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician brings today's primary care physician, neurologist, gerontologist, and internist the critically evaluated knowledge and up-to-date expertise needed to treat patients with movement disorders in full confidence. A. Basic Diagnostic Principles. 1. Approach To The Patient With A Movement Disorder: Basic Principles Of Neurologic Diagnosis / J. Eric Ahlskog. 2. Motor Speech Disorders: Clues To Neurologic Diagnosis / Joseph R. Duffy --^ B. Parkinson's Disease. 3. What Is Parkinson's Disease? Neuropathology, Neurochemistry, And Pathophysiology / Howard Hurtig. 4. Clinical Features Of Parkinson's Disease / Richard B. Dewey, Jr. 5. Epidemiology And Genetics Of Parkinson's Disease / Demetrius M. (jim) Maraganore. 6. Parkinson's Disease: Etiologic Considerations / Peter A. Lewitt. 7. Medication Strategies For Slowing The Progression Of Parkinson's Disease / J. Eric Ahlskog. 8. Initial Symptomatic Treatment Of Parkinson's Disease / J. Eric Ahlskog. 9. Advancing Parkinson's Disease And Treatment Of Motor Complications / Ryan J. Uitti. 10. Sleep And Parkinson's Disease / Cynthia L. Comella. 11. Autonomic Complications Of Parkinson's Disease / Bradley C. Hiner. 12. Treatment Of Cognitive Disorders And Depression Associated With Parkinson's Disease / Erwin B. Montgomery, Jr. 13. Surgical Treatment Of Parkinson's Disease / Kathleen M. Shannon. 14.^ Adjunctive Therapies In Parkinson's Disease: Diet, Physical Therapy, And Networking / Padraig E. O'suilleabhain And Susan M. Murphy -- C. Parkinsonism But Not Parkinson's Disease (other Akinetic-rigid Syndromes). 15. Secondary Causes Of Parkinsonism / Eric S. Molho And Stewart A. Factor. 16. Progressive Supranuclear Palsy / Mark Stacy. 17. Multiple System Atrophy / James H. Bower. 18. Familial Adult-onset Spinocerebellar Degenerations / James H. Bower. 19. Corticobasal Degeneration / Bradley F. Boeve. 20. Parkinsonism In Primary Degenerative Dementia / Richard J. Caselli --^ D. Movement Disorders Characterized By Excessive Movement (hyperkinetic). 21. Tremor Disorders: Overview / Joseph Y. Matsumoto. 22. Essential Tremor: Diagnosis And Treatment / Jean Pintar Hubble. 23. Dystonia / Daniel Tarsy. 24. Hemifacial Spasm / Mark F. Lew. 25. Huntington's Disease And Other Choreas / John N. Caviness. 26. Tardive Dyskinesias / Kapil D. Sethi. 27. Myoclonus / John N. Caviness. 28. Spasms And Stiff-man Syndrome / C. Michel Harper, Jr. 29. Gilles De La Tourette's Syndrome And Tic Disorders / Kathleen A. Kujawa And Christopher G. Goetz. 30. Restless Legs Syndrome / Virgilio Gerald H. Evidente And Charles H. Adler. 31. Botulinum Toxin Treatment Of Movement Disorders / Charles H. Adler --^ E. Other Movement Disorders. 32. Wilson's Disease / Katrina A. Gwinn-hardy. 33. Gait Disorders: Recognition Of Classic Types / Frank A. Rubino. 34. Post-traumatic Movement Disorders / Sotirios A. Parashos. 35. Psychogenic Movement Disorders: Theoretical And Clinical Considerations / David S. Glosser And Matthew B. Stern. Edited By Charles H. Adler And J. Eric Ahlskog. Includes Bibliographical References And Index. Front Matter....Pages i-xiv Front Matter....Pages 1-1 Approach to the Patient With a Movement Disorder: Basic Principles of Neurologic Diagnosis....Pages 3-34 Motor Speech Disorders: Clues to Neurologic Diagnosis....Pages 35-53 Front Matter....Pages 55-55 What Is Parkinson’s Disease? Neuropathology, Neurochemistry, and Pathophysiology....Pages 57-70 Clinical Features of Parkinson’s Disease....Pages 71-84 Epidemiology and Genetics of Parkinson’s Disease....Pages 85-90 Parkinson’s Disease: Etiologic Considerations....Pages 91-100 Medication Strategies for Slowing the Progression of Parkinson’s Disease....Pages 101-114 Initial Symptomatic Treatment of Parkinson’s Disease....Pages 115-128 Advancing Parkinson’s Disease and Treatment of Motor Complications....Pages 129-149 Sleep and Parkinson’s Disease....Pages 151-160 Autonomic Complications of Parkinson’s Disease....Pages 161-174 Treatment of Cognitive Disorders and Depression Associated With Parkinson’s Disease....Pages 175-183 Surgical Treatment or Parkinson’s Disease....Pages 185-196 Adjunctive Therapies in Parkinson’s Disease: Diet, Physical Therapy, and Networking....Pages 197-208 Front Matter....Pages 209-210 Secondary Causes of Parkinsonism....Pages 211-228 Progressive Supranuclear Palsy....Pages 229-234 Multiple System Atrophy....Pages 235-242 Familial Adult-Onset Spinocerebellar Degenerations....Pages 243-252 Corticobasal Degeneration....Pages 253-261 Parkinsonism in Primary Degenerative Dementia....Pages 263-270 Front Matter....Pages 271-272 Tremor Disorders: Overview....Pages 273-281 Essential Tremor: Diagnosis and Treatment....Pages 283-295 Dystonia....Pages 297-311 Hemifacial Spasm....Pages 313-319 Huntington’s Disease and Other Choreas....Pages 321-330 Tardive Dyskinesias....Pages 331-338 Myoclonus....Pages 339-350 Spasms and Stiff-man Syndrome....Pages 351-364 Gilles de la Tourette’s Syndrome and Tic Disorders....Pages 365-372 Restless Legs Syndrome....Pages 373-384 Botulinum Toxin Treatment of Movement Disorders....Pages 385-394 Front Matter....Pages 395-395 Wilson’s Disease....Pages 397-410 Gait Disorders: Recognition of Classic Types....Pages 411-425 Post-traumatic Movement Disorders....Pages 427-434 Psychogenic Movement Disorders: Theoretical and Clinical Considerations....Pages 435-451 Back Matter....Pages 453-474 The field of movement disorders is relatively broad, encompassing disorders of increased movement, such as tremors, dystonia, and tics, to disorders characterized by a paucity of movement, such as Parkinson's disease. Our understanding of the pathogenic mechanisms and our treatment options are expanding at a rapid pace. This expansion ranges from the medical and surgical advances in treating Parkinson's disease to the flood of genetic abnormalities that have now been found to cause various movement disorders. Although many patients are seen by the movement disorders specialist in neurology clinics around the country, most of these patients receive their followup care from a primary care physician or "general" neurologist who must be versed in the character­ istics and treatment plans of this diverse group of disorders. The major goal of Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician is to distill this immense amount of information and to educate the practitioner about the many facets of the movement disorders field. We believe that this book fills a large void, since most texts on movement disorders are more detailed and geared toward the specialist. We have asked the chapter authors to emphasize the clinical characteristics of each disorder, discuss the differential diagnosis and the diagnostic testing, and then outline the various treatment options, as if they were teaching during a preceptorship in their clinic.

Highly experienced clinician-researchers distill the immense amount of new information now available about movement disorders to create a practice-oriented tutorial for all physicians treating movement disorders. Their book helps physicians to distinguish each disorder, providing a basic understanding of both the test and treatment options needed in active practices, as well as the effective use of the therapeutic recommendations of consulting specialists. The first half of the book is devoted to Parkinson's disease and conditions masquerading as parkinsonism, while the remainder details the recognition and treatment of tremor, dystonia, chorea, myoclonus, tics, gait disorders, the ataxias, conditions resulting in spasms, and restless legs syndrome. In all cases, Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician provides sufficient background so that even relatively inexperienced clinicians can readily master the diagnosis and treatment of these neurologic conditions.

The book contains black-and-white illustrations.

This initial chapter addresses basic principles of neurologic examination and diagnosis and defines some of the broader diagnostic categories as an introduction to the remainder of this text.