Pancreatic Islet Cell Regeneration and Growth (Advances in Experimental Medicine and Biology (321))

Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors. Front Matter....Pages i-ix Introduction....Pages 1-5 Front Matter....Pages 7-7 The Role of Growth Hormone and Prolactin in Beta Cell Growth and Regeneration....Pages 9-20 The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration....Pages 21-30 The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System....Pages 31-36 Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes....Pages 37-44 Oncogenes and Cell Growth....Pages 45-51 Interferon — A Candidate Mediator of Cell Growth....Pages 53-58 Front Matter....Pages 59-59 Islet β-Cell Regeneration and Reg Genes....Pages 61-69 Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat....Pages 71-84 Regeneration of Pancreatic Endocrine Cells in Interferon-Gamma Transgenic Mice....Pages 85-93 Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes....Pages 95-109 Front Matter....Pages 111-111 Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs....Pages 113-122 The Partial Isolation and Characterization of Ilotropin, a Novel Islet-Specific Growth Factor....Pages 123-132 Expression of Growth Factors in a Pancreatic Islet Regeneration Model....Pages 133-141 Role of p21 ras in Hormone Signalling and Cell Growth/Transformation....Pages 143-146 Phosphoinositides and Cell Growth....Pages 147-151 The Physiological Stop Pathway: Target Regulation of Axonal Growth....Pages 153-157 Calcium Regulation of Myosin I — A Motor for Membrane Movement....Pages 159-163 Front Matter....Pages 165-165 Amylin Expression in the Pancreatic β-Cell....Pages 167-169 Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat....Pages 171-177 Back Matter....Pages 179-187 Aaron I. Vinik, M.D., Ph. D.I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors The proceedings of a Diabetes Institute conference in Norfolk, Virginia, June 1991. The 19 papers cover the regulation of cell growth and development, models for the study of cell regeneration, the induction of cell growth and mechanisms, and pathogenic and therapeutic ramifications. The contributors are from North America, Denmark, and Japan, and represent a wide range of medical and scientific disciplines.