Paediatrics and Blood Transfusion : Proceedings of the Fifth Annual Symposium on Blood Transfusion, Groningen 1980 Organized by the Red Cross Bloodbank Groningen-Drenthe

The practice of transfusing blood started at the bedside but over the last few decades blood transfusion has become more and more a laboratory directed discipline. The emphasis on serology and laboratory controlled measures has made blood transfusion safer and more effective, but laboratory and clinical aspects of the discipline have tended to become increasingly separated. As a result of this separation clinical developments in blood transfusion may not have derived full benefit from the knowledge accrued in blood transfusion services. Over the last five years the Red Cross Blood Bank Groningen-Drenthe has organised yearly symposia with a clinical theme in order to bring blood banks and clinicians closer together. Many of the recent major advances in clinical medicine have been based on developments in blood transfusion practice. This is certainly true for paediatric medicine. For instance, in paediatric oncology, including leukemia, cell separator programmes have made available new forms of support. Further, blood component therapy has provided an effective means of control in some of the bleeding disorders of children. Some of these topics are discussed in this symposium dealing with intensive care. Haemolytic disease of the newborn and exchange transfusion are other aspec.ts of intensive care. Our purpose in dealing with them was twofold. Front Matter....Pages I-XIII Historical Perspectives of Haemolytic Disease of the Newborn....Pages 1-3 The Serological Investigation of Haemolytic Disease of the Newborn....Pages 4-21 The Laboratory Investigation of ABO Haemolytic Disease of the Newborn and Dangers Arising from the Transfusion of Group O Donor-Blood Containing AB Bloodgroup Substance of Animal Origin....Pages 22-27 Haemolytic Disease: Clinical Diagnosis....Pages 28-33 Discussion....Pages 34-36 The Supply of Anti-Rhesus (D) Immunoglobulin in the Netherlands....Pages 37-39 Anti-Rhesus (D) Immunoglobulin: Indications, Clinical Use and Effect on Incidence of Haemolytic Disease of the Newborn....Pages 40-48 Discussion....Pages 49-52 Haemolytic Disease of the Newborn: An Overview of the Principles of Therapy....Pages 53-65 The Use of Component Therapy in the Newborn....Pages 66-72 Metabolic Effects of Exchange Transfusion....Pages 73-83 Exchange Transfusion: Metabolic Aspects and Biochemical Changes....Pages 84-91 Discussion....Pages 92-96 Paediatrics and Bloodtransfusion: Practical Aspects....Pages 97-112 Practical Aspects of Exchange Transfusion....Pages 113-118 Indications for Exchange Transfusion and Choice of Treatment for Haemolytic Disease of the Newborn....Pages 119-128 Progress in Exchange Transfusion Techniques....Pages 129-134 Practical Experience in Neonatal Exchange Transfusion....Pages 135-137 Exchange Transfusion in the Netherlands: A Personal View....Pages 138-152 Discussion....Pages 153-158 Use of Infusion Pumps for Paediatric Blood Transfusion....Pages 159-163 Prevention of Severe Haemolytic Disease of the Newborn by Weekly Small-Volume Plasamapheresis During Pregnancy....Pages 164-170 Intrauterine Fetal Transfusion in Severe Rh Isoimmunisation....Pages 171-176 Development of Infants Surviving Intrauterine Transfusions....Pages 177-183 Discussion....Pages 184-184 Cytomegalovirus Infections....Pages 185-190 Serodiagnosis and Control in Viral Hepatitis....Pages 191-206 Discussion....Pages 207-209 Some Aspects of Neonatal Thrombocytopenia....Pages 210-222 Cytapheresis Support in Childhood Oncology....Pages 223-227 Platelet Transfusion in Bone Marrow Transplantation in Children....Pages 228-236 Discussion....Pages 237-238 Concluding Remarks....Pages 239-240 This book contains the proceedings of a symposium on the use of synthetic substrates in clinical blood coagulation assays, which was held at the University of Leuven, Belgium, on March 1st, 1980. This meeting was organized in order to exchange and discuss recent develop­ ments and applications in this field. Advantages and disadvantages of synthetic substrates are discussed, while expert workers report on their practical experience with the use of chromogenic substrates in routine assays for blood coagulation and fibrinolysis. The indications when to perform antithrombin III, a2-antiplasmin, factor X and factor II determinations are discussed. For each of the determinations a critical evaluation of the chromogenic assay as compared to the classical assay is presented. The clinical relevance of these assays for anticoagulated and cirrhotic patients, detection of vitamin K deficiency, monitoring heparin therapy and the fibrinolytic system are discussed. Recent developments in the use of fluorogenic substrates for the assay of low concentrations of fibrin­ olytic activators are presented. Taking into account all practical, medical and economical con­ siderations an answer is prepared to the question'Are synthetic sub­ strates to be recommended for routine use?'. To make this symposium useful, rapid publication of the proceedings has been undertaken. We are grateful to the participants in this meeting for their co­ operation and for their willingness to provide manuscripts of their presentations. The manuscripts provided by C. Kluft and H.H.D.M. Yet, even if epidemiological studies clearly indicate the existence of an association between the amount of composition of dietary lipids and morbidity and mortality of cardio- vascular disease, our basic knowledge on cause and effect is still hidden in a cloud of uncertainty. Edited By H. R. Lijnen, D. Collen, M. Verstraete. Proceedings Of A Symposium Held At The University Of Leuven, Belgium, Mar. 1, 1980. Includes Bibliographical References. Proceedings of the Seventh Annual Symposium on Blood Transfusion, Groningen, 1982, organized by the Red Cross Blood Bank Groningen-Drenthe Proceedings of the Tenth Annual Symposium on Blood Transfusion, Groningen 1985, organized by the Red Cross Blood Bank Groningen-Drenthe