Oxygen Transport to Tissue XXXVII (Advances in Experimental Medicine and Biology, 876)

"This book contains the refereed contributions from the 42nd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 42nd annual meeting, which included sessions on: cellular hypoxia and mitochondria; blood substitutes and oxygen therapeutics; oxygen transport in critical care medicine and disease; muscle oxygenation; multi modal imaging techniques; brain oxygenation and imaging; optical techniques for oxygen measurement; microcirculation; mathematical modelling of oxygen transport; and cancer metabolism"--Publisher's description Front Matter....Pages i-xxxii The Most Important Discovery of Science....Pages 1-16 Front Matter....Pages 17-17 The Spatial Distribution of Absolute Skeletal Muscle Deoxygenation During Ramp-Incremental Exercise Is Not Influenced by Hypoxia....Pages 19-26 Do Two Tissue Blood Volume Parameters Measured by Different Near-Infrared Spectroscopy Methods Show the Same Dynamics During Incremental Running?....Pages 27-33 Underwater Near-Infrared Spectroscopy: Muscle Oxygen Changes in the Upper and Lower Extremities in Club Level Swimmers and Triathletes....Pages 35-40 Muscle Oxygenation During Running Assessed by Broad Band NIRS....Pages 41-47 Regional Differences in Muscle Energy Metabolism in Human Muscle by 31P-Chemical Shift Imaging....Pages 49-54 Sex-Related Difference in Muscle Deoxygenation Responses Between Aerobic Capacity-Matched Elderly Men and Women....Pages 55-61 Effects of Low Volume Aerobic Training on Muscle Desaturation During Exercise in Elderly Subjects....Pages 63-69 Differences in Contraction-Induced Hemodynamics and Surface EMG in Duchenne Muscular Dystrophy....Pages 71-77 Changes in Cortical Oxyhaemoglobin Signal During Low-Intensity Cycle Ergometer Activity: A Near-Infrared Spectroscopy Study....Pages 79-85 Validation of a New Semi-Automated Technique to Evaluate Muscle Capillarization....Pages 87-93 Reduction in Cerebral Oxygenation After Prolonged Exercise in Hypoxia is Related to Changes in Blood Pressure....Pages 95-100 Front Matter....Pages 101-101 The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion....Pages 103-110 Simulation of Preterm Neonatal Brain Metabolism During Functional Neuronal Activation Using a Computational Model....Pages 111-120 Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation....Pages 121-127 A Discussion on the Regulation of Blood Flow and Pressure....Pages 129-135 Front Matter....Pages 137-137 Near Infrared Light Scattering Changes Following Acute Brain Injury....Pages 139-144 Comparison of Cerebral Oxygen Saturation and Cerebral Perfusion Computed Tomography in Cerebral Blood Flow in Patients with Brain Injury....Pages 145-149 Detection of ROSC in Patients with Cardiac Arrest During Chest Compression Using NIRS: A Pilot Study....Pages 151-157 Myocardial Microcirculation and Mitochondrial Energetics in the Isolated Rat Heart....Pages 159-165 Front Matter....Pages 167-167 Tissue Discs: A 3D Model for Assessing Modulation of Tissue Oxygenation....Pages 169-175 Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression....Pages 177-183 Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy....Pages 185-193 Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy....Pages 195-200 Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors....Pages 201-207 Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro....Pages 209-214 Acidosis Promotes Metastasis Formation by Enhancing Tumor Cell Motility....Pages 215-220 Front Matter....Pages 221-221 Preoperative Stress Conditioning in Humans: Is Oxygen the Drug of Choice?....Pages 223-231 In Vivo Imaging of Flavoprotein Fluorescence During Hypoxia Reveals the Importance of Direct Arterial Oxygen Supply to Cerebral Cortex Tissue....Pages 233-239 Cardiovascular Adaptation in Response to Chronic Hypoxia in Awake Rats....Pages 241-246 Prototyping the Experimental Setup to Quantify the Tissue Oxygen Consumption Rate and Its Preliminary Test....Pages 247-255 Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring....Pages 257-263 Aging Effect on Post-recovery Hypofusion and Mortality Following Cardiac Arrest and Resuscitation in Rats....Pages 265-270 Front Matter....Pages 271-271 Using fNIRS to Study Working Memory of Infants in Rural Africa....Pages 273-279 Gender and Age Analyses of NIRS/STAI Pearson Correlation Coefficients at Resting State....Pages 281-287 Effects of Cosmetic Therapy on Cognitive Function in Elderly Women Evaluated by Time-Resolved Spectroscopy Study....Pages 289-295 Effects of Acupuncture on Anxiety Levels and Prefrontal Cortex Activity Measured by Near-Infrared Spectroscopy: A Pilot Study....Pages 297-302 Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects....Pages 303-309 Spontaneous Fluctuations of PO2 in the Rabbit Somatosensory Cortex....Pages 311-317 Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQTM) on Cognitive Functions....Pages 319-325 Front Matter....Pages 271-271 Estimation of Skin Blood Flow Artefacts in NIRS Signals During a Verbal Fluency Task....Pages 327-334 Effect of Transcranial Direct Current Stimulation over the Primary Motor Cortex on Cerebral Blood Flow: A Time Course Study Using Near-infrared Spectroscopy....Pages 335-341 Relationships Between Gum-Chewing and Stress....Pages 343-349 Effects of Anodal High-Definition Transcranial Direct Current Stimulation on Bilateral Sensorimotor Cortex Activation During Sequential Finger Movements: An fNIRS Study....Pages 351-359 Front Matter....Pages 361-361 Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging....Pages 363-369 Evaluation of Brown Adipose Tissue Using Near-Infrared Time-Resolved Spectroscopy....Pages 371-376 Near-Infrared Image Reconstruction of Newborns’ Brains: Robustness to Perturbations of the Source/Detector Location....Pages 377-382 Front Matter....Pages 383-383 Simultaneous Measurement of Dissolved Oxygen Pressure and Oxyhemoglobin Spectra in Solution....Pages 385-390 Local Measurement of Flap Oxygen Saturation: An Application of Visible Light Spectroscopy....Pages 391-397 Hemodynamic Measurements of the Human Adult Head in Transmittance Mode by Near-Infrared Time-Resolved Spectroscopy....Pages 399-406 Non-invasive Monitoring of Hepatic Oxygenation Using Time-Resolved Spectroscopy....Pages 407-412 Comparison of Near-Infrared Oximeters in a Liquid Optical Phantom with Varying Intralipid and Blood Content....Pages 413-418 Improvement of Speckle Contrast Image Processing by an Efficient Algorithm....Pages 419-425 A Clinical Tissue Oximeter Using NIR Time-Resolved Spectroscopy....Pages 427-433 Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature....Pages 435-441 Front Matter....Pages 443-443 Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-Based Oxygen Carriers (HBOCs)....Pages 445-453 The βLys66Tyr Variant of Human Hemoglobin as a Component of a Blood Substitute....Pages 455-460 PEGylated Bovine Carboxyhemoglobin (SANGUINATETM): Results of Clinical Safety Testing and Use in Patients....Pages 461-467 Front Matter....Pages 469-469 Oxygen Supplementation is Effective in Attenuating Maternal Cerebral Blood Deoxygenation After Spinal Anesthesia for Cesarean Section....Pages 471-477 Changes in Cerebral Blood Flow and Oxygenation During Induction of General Anesthesia with Sevoflurane Versus Propofol....Pages 479-484 Front Matter....Pages 469-469 Neurovascular Interactions in the Neurologically Compromised Neonatal Brain....Pages 485-492 In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke....Pages 493-499 A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS....Pages 501-509 Characterizing Fluctuations of Arterial and Cerebral Tissue Oxygenation in Preterm Neonates by Means of Data Analysis Techniques for Nonlinear Dynamical Systems....Pages 511-519 Can the Assessment of Spontaneous Oscillations by Near Infrared Spectrophotometry Predict Neurological Outcome of Preterm Infants?....Pages 521-531 Back Matter....Pages 533-537