Oxygen Transport to Tissue XXXVI (Advances in Experimental Medicine and Biology Book 812)

This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme “the wisdom of ISOTT” in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integrated overviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer. Chapters 22, 24, 25 and 26 are open access under a CC BY 4.0 license via link.springer.com. Front Matter....Pages i-xxx Mitochondrial Genetic Abnormalities After Radiation Exposure....Pages 1-7 Crediting Six Discoverers of Oxygen....Pages 9-17 Hypoxia in Tumors: Pathogenesis-Related Classification, Characterization of Hypoxia Subtypes, and Associated Biological and Clinical Implications....Pages 19-24 Heterogeneity in Tissue Oxygenation: From Physiological Variability in Normal Tissues to Pathophysiological Chaos in Malignant Tumours....Pages 25-31 Oxygen Diffusion: An Enzyme-Controlled Variable Parameter....Pages 33-41 Role of Microvascular Shunts in the Loss of Cerebral Blood Flow Autoregulation....Pages 43-49 Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo ....Pages 51-58 The Founding of ISOTT: The Shamattawa of Engineering Science and Medical Science....Pages 59-63 A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism....Pages 65-71 Advances in Probes and Methods for Clinical EPR Oximetry....Pages 73-79 Real-Time, In Vivo Determination of Dynamic Changes in Lung and Heart Tissue Oxygenation Using EPR Oximetry....Pages 81-86 Modulation of Hypoxia by Magnetic Nanoparticle Hyperthermia to Augment Therapeutic Index....Pages 87-95 Skeletal Muscle and Glioma Oxygenation by Carbogen Inhalation in Rats: A Longitudinal Study by EPR Oximetry Using Single-Probe Implantable Oxygen Sensors....Pages 97-103 Recurrent Low-Dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors....Pages 105-111 How In Vivo EPR Measures and Images Oxygen....Pages 113-119 What We Learn from In Vivo EPR Oxygen Images....Pages 121-126 EPR Image Based Oxygen Movies for Transient Hypoxia....Pages 127-133 Repetitive Measurements of Intrarenal Oxygenation In Vivo Using L Band Electron Paramagnetic Resonance....Pages 135-141 Quantitative Hypoxia Imaging for Treatment Planning of Radiotherapy....Pages 143-148 A New Flavonoid Regulates Angiogenesis and Reactive Oxygen Species Production....Pages 149-155 Angiotensin II Reduces Transport-Dependent Oxygen Consumption but Increases Transport-Independent Oxygen Consumption in Immortalized Mouse Proximal Tubular Cells....Pages 157-163 Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery....Pages 165-171 Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS....Pages 173-179 Development of a Near Infrared Multi-Wavelength, Multi-Channel, Time-Resolved Spectrometer for Measuring Brain Tissue Haemodynamics and Metabolism....Pages 181-186 Simulating NIRS and MRS Measurements During Cerebral Hypoxia-Ischaemia in Piglets Using a Computational Model....Pages 187-193 Analysis of Slow Wave Oscillations in Cerebral Haemodynamics and Metabolism Following Subarachnoid Haemorrhage....Pages 195-201 Effects of Enriched Environment on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Global Ischemia....Pages 203-208 Automated Image Analysis for Diameters and Branching Points of Cerebral Penetrating Arteries and Veins Captured with Two-Photon Microscopy....Pages 209-215 Cerebral Hemodynamic Change and Metabolic Alteration in Severe Hemorrhagic Shock....Pages 217-223 Physiological Mechanism of Increase in Deoxy-hemoglobin Concentration During Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model....Pages 225-231 Effect of Blood in the Cerebrospinal Fluid on the Accuracy of Cerebral Oxygenation Measured by Near Infrared Spectroscopy....Pages 233-240 Vessel Specific Imaging of Glucose Transfer with Fluorescent Glucose Analogue in Anesthetized Mouse Cortex....Pages 241-246 Ischemic Pretreatment Delays Ischemic Brain Vasospasm Injury in Gerbils....Pages 247-252 Changes in Cerebral Blood Oxygenation Induced by Active Standing Test in Children with POTS and NMS....Pages 253-261 Optical Imaging of Brain Activation in Gambian Infants....Pages 263-269 Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome....Pages 271-278 Changes of Cerebral Tissue Oxygen Saturation at Sleep Transitions in Adolescents....Pages 279-285 Influence of Subjective Happiness on the Prefrontal Brain Activity: An fNIRS Study....Pages 287-293 Ginkobiloba Extract Improves Working Memory Performance in Middle-Aged Women: Role of Asymmetry of Prefrontal Cortex Activity During a Working Memory Task....Pages 295-301 Bayesian Prediction of Anxiety Level in Aged People at Rest Using 2-Channel NIRS Data from Prefrontal Cortex....Pages 303-308 Short-Term Hypoxic Preconditioning Improved Survival Following Cardiac Arrest and Resuscitation in Rats....Pages 309-315 Venular Valves and Retrograde Perfusion....Pages 317-323 Monitoring of Filter Patency During Carotid Artery Stenting Using Near-Infrared Spectroscopy with High Time-Resolution....Pages 325-331 Use of NIRS to Assess Effect of Training on Peripheral Muscle Oxygenation Changes in Elite Rugby Players Performing Repeated Supramaximal Cycling Tests....Pages 333-339 Skeletal Muscle Deoxygenation Responses During Treadmill Exercise in Children....Pages 341-346 Development of a Hybrid Microwave-Optical Thermoregulation Monitor for the Muscle....Pages 347-353 Evaluation of a Textile-Based Near Infrared Spectroscopy System in Calf Muscle Oxygenation Measurements....Pages 355-360 Skin Temperature in Lower Hind Limb Subjected to Distal Vein Arterialization in Rats....Pages 361-368 Back Matter....Pages 369-372 "This book contains the refereed contributions from the 41st annual meeting of ISOTT The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc) in a unique international forum Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting Special features in this volume include invited presentations from senior members of ISOTT for the theme “the wisdom of ISOTT” in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integrated overviews of critical aspects of the field The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer - Font no determinada This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, et cetera) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme "the wisdom of ISOTT" in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integrated overviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation.