Oxygen Transport to Tissue XXXIX (Advances in Experimental Medicine and Biology Book 977)

This volume presents all aspects of delivery of oxygen to tissues and tumors in peer reviewed short articles. Both overview and the most recent, advanced techniques for oxygen measurement are presented. Articles and peer reviewers include those from leaders in their field. Topics such as molecular signaling in the organismal and tumor response to low levels of local oxygenation, hypoxia inducible factor (HIF) , cancer metabolism, individual human and animal response to oxygen changes monitored by optical/near infrared spectroscopy/ tomography to novel electron resonance spectroscopy and spectroscopic imaging, instrumentation, progress in blood substitute research, retinal physiology, cellular hypoxia, mitochondrial function; brain oxygenation and function; oxygen transport in sports, hypoxia in diseases and clinical care. Chapters 10 and 19 of this book are open access under a CC BY 4.0 license. Front Matter....Pages i-xxx Front Matter....Pages 1-1 Oxygen Sensing by the Carotid Body: Past and Present....Pages 3-8 Predicted Decrease in Membrane Oxygen Permeability with Addition of Cholesterol....Pages 9-14 Chronic Diseases as Barriers to Oxygen Delivery: A Unifying Hypothesis of Tissue Reoxygenation Therapy....Pages 15-20 Dorsiflexor Muscle Oxygenation During Low, Moderate and Submaximal Sustained Isometric Contraction....Pages 21-26 Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport Across Eye Lens Fiber-Cell Plasma Membranes....Pages 27-34 Multi-site Measurements of Muscle O2 Dynamics During Cycling Exercise in Early Post-myocardial Infarction....Pages 35-41 Effects of 8 Weeks’ Training on Systemic and Muscle Oxygen Dynamics in University Rugby Players....Pages 43-49 Imaging Redox State in Mouse Muscles of Different Ages....Pages 51-57 Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model....Pages 59-65 Evaluation of Haemoglobin and Cytochrome Responses During Forearm Ischaemia Using Multi-wavelength Time Domain NIRS....Pages 67-72 Influence of Free Radicals on the Intrinsic MRI Relaxation Properties....Pages 73-79 Inter-individual Differences in Exercise-Induced Spatial Working Memory Improvement: A Near-Infrared Spectroscopy Study....Pages 81-88 Front Matter....Pages 89-89 Tumor Oxygenation Status: Facts and Fallacies....Pages 91-99 Multiparametric Analysis of the Tumor Microenvironment: Hypoxia Markers and Beyond....Pages 101-107 Computational Simulation of Tumor Hypoxia Based on In Vivo Microvasculature Assessed in a Dorsal Skin Window Chamber....Pages 109-117 Hypoxia-Related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells....Pages 119-124 Front Matter....Pages 125-125 Cortical and Autonomic Stress Responses in Adults with High Versus Low Levels of Trait Anxiety: A Pilot Study....Pages 127-132 Relation Between EEG Activity and Brain Oxygenation in Preterm Neonates....Pages 133-139 Functional NIRS Measurement of Cytochrome-C-Oxidase Demonstrates a More Brain-Specific Marker of Frontal Lobe Activation Compared to the Haemoglobins....Pages 141-147 Brain Tissue PO2 Measurement During Normoxia and Hypoxia Using Two-Photon Phosphorescence Lifetime Microscopy....Pages 149-153 Front Matter....Pages 125-125 Age-Related Changes in Physiological Reactivity to a Stress Task: A Near-Infrared Spectroscopy Study....Pages 155-161 Development and Validation of a Sensor Prototype for Near-Infrared Imaging of the Newborn Brain....Pages 163-168 Directional Migration of MDA-MB-231 Cells Under O2/pH Gradients....Pages 169-174 Environmental Enrichment Induces Increased Cerebral Capillary Density and Improved Cognitive Function in Mice....Pages 175-181 Improving Retinal Image Quality Using Registration with an SIFT Algorithm in Quasi-Confocal Line Scanning Ophthalmoscope....Pages 183-190 A New Method Based on Graphics Processing Units for Fast Near-Infrared Optical Tomography....Pages 191-197 PFC Blood Oxygenation Changes in Four Different Cognitive Tasks....Pages 199-204 Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse....Pages 205-213 Evaluation of Pleasure-Displeasure Induced by Use of Lipsticks with Near-Infrared Spectroscopy (NIRS): Usefulness of 2-Channel NIRS in Neuromarketing....Pages 215-220 Relationships Between Gum Chewing and Stroop Test: A Pilot Study....Pages 221-226 Effects of Motor Imagery on Cognitive Function and Prefrontal Cortex Activity in Normal Adults Evaluated by NIRS....Pages 227-231 Site Specificity of Changes in Cortical Oxyhaemoglobin Concentration Induced by Water Immersion....Pages 233-240 Changes in Oxyhemoglobin Concentration in the Prefrontal Cortex and Primary Motor Cortex During Low- and Moderate-Intensity Exercise on a Cycle Ergometer....Pages 241-247 Tissue Blood Volume Parameters Measured by Continuous-Wave and Spatially Resolved NIRS Show Different Changes During Prolonged Cycling Exercise....Pages 249-254 Delayed Onset of Reoxygenation in Inactive Muscles After High-Intensity Exercise....Pages 255-260 Cortical Oxyhemoglobin Elevation Persists After Moderate-Intensity Cycling Exercise: A Near-Infrared Spectroscopy Study....Pages 261-268 Relation Between Cognitive Function and Baseline Concentrations of Hemoglobin in Prefrontal Cortex of Elderly People Measured by Time-Resolved Near-Infrared Spectroscopy....Pages 269-276 Physiological Effects of Continuous Colored Light Exposure on Mayer Wave Activity in Cerebral Hemodynamics: A Functional Near-Infrared Spectroscopy (fNIRS) Study....Pages 277-283 Front Matter....Pages 285-285 Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization....Pages 287-296 Using India Ink as a Sensor for Oximetry: Evidence of its Safety as a Medical Device....Pages 297-312 Front Matter....Pages 285-285 Measurement of pO2 in a Pre-clinical Model of Rabbit Tumor Using OxyChip, a Paramagnetic Oxygen Sensor....Pages 313-318 Correlation Between Hypoxia Proteins and EPR-Detected Hypoxia in Tumors....Pages 319-325 Triarylmethyl Radical OX063d24 Oximetry: Electron Spin Relaxation at 250 MHz and RF Frequency Dependence of Relaxation and Signal-to-Noise....Pages 327-334 In Vivo EPR Resolution Enhancement Using Techniques Known from Quantum Computing Spin Technology....Pages 335-339 Front Matter....Pages 341-341 Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward....Pages 343-350 The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin....Pages 351-357 Methemoglobin: A New Way to Distinguish Burn Depth....Pages 359-365 Characterization of Protein-Protein Interactions in Recombinant Hemoglobin Producing Escherichia coli Cells Using Molecularly Imprinted Polymers....Pages 367-373 Front Matter....Pages 375-375 Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia....Pages 377-383 Optical Design of Adaptive Optics Confocal Scanning Laser Ophthalmoscope with Two Deformable Mirrors....Pages 385-392 Construction of 0.15 Tesla Overhauser Enhanced MRI....Pages 393-398 Gold Nanoparticle-Based Fluorescent Contrast Agent with Enhanced Sensitivity....Pages 399-407 Potential Erythropoiesis in the Primo-Vascular System in Heart Failure....Pages 409-415 Front Matter....Pages 417-417 Quantitative Biology of Exercise-Induced Signal Transduction Pathways....Pages 419-424 Back Matter....Pages 425-435