Oxygen Transport to Tissue XXXIII (Advances in Experimental Medicine and Biology Book 737)

Based on the 38th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Ascona, Switzerland in July 2010, this volume covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence. It covers near infrared spectroscopy, brain oxygenation, tumor biology, angiogenesis and mitochondrial metabolism, systems modeling, gas transport, hypoxic adaptation and exercise physiology. Emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biological bases for pathology related to tissue oxygenation. This multidisciplinary volume includes contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians. Front Matter....Pages i-xx Front Matter....Pages 11-11 The History of ISOTT....Pages 1-9 Front Matter....Pages 11-11 Angioplasticity and Cerebrovascular Remodeling....Pages 13-17 Cerebral Monitoring Using Near-Infrared Time-Resolved Spectroscopy and Postoperative Cognitive Dysfunction....Pages 19-24 Comparison of the Kinetics of Pulmonary Oxygen Uptake and Middle Cerebral Artery Blood Flow Velocity During Cycling Exercise....Pages 25-31 Colored Light and Brain and Muscle Oxygenation....Pages 33-36 Frontal Cortex Activation During Electrical Muscle Stimulation as Revealed by Functional Near-Infrared Spectroscopy....Pages 37-44 Cerebral Oxygen Saturation Measurements in Red Cell Transfusion....Pages 45-49 Influence of Stress Preconditioning on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Cerebral Ischemia....Pages 51-56 Differential Effects of Delta and Epsilon Protein Kinase C in Modulation of Postischemic Cerebral Blood Flow....Pages 57-61 Optical Topography to Measure Variations in Regional Cerebral Oxygenation in an Infant Supported on Veno-Arterial Extra-Corporeal Membrane Oxygenation....Pages 63-69 Effects of the Autonomic Nervous System on Functional Neuroimaging: Analyses Based on the Vector Autoregressive Model....Pages 71-76 Assessment of Potential Short-Term Effects of Intermittent UMTS Electromagnetic Fields on Blood Circulation in an Exploratory Study, Using Near-Infrared Imaging....Pages 77-82 Optical Diagnosis of Mental Stress: Review....Pages 83-88 Neuroprotective Properties of Ketone Bodies....Pages 89-95 The Confounding Effect of Systemic Physiology on the Hemodynamic Response in Newborns....Pages 97-102 How to Conduct Studies with Neonates Combining Near-Infrared Imaging and Electroencephalography....Pages 103-109 Use of a Hybrid Optical Spectrometer for the Measurement of Changes in Oxidized Cytochrome c Oxidase Concentration and Tissue Scattering During Functional Activation....Pages 111-117 Front Matter....Pages 119-124 Isolated Hypoxic Liver Perfusion with Melfalan in Humans and Its Anesthesiologic Aspects....Pages 125-125 Blood Flow and Oxygenation Status of Gastrointestinal Tumors....Pages 127-132 Front Matter....Pages 133-138 Delayed Effects of Radiation on Mitochondrial DNA in Radiation-Sensitive Organs....Pages 125-125 Radiation-Induced Elevation of Plasma DNA in Mice is Associated with Genomic Background....Pages 139-145 Could Multiple Myeloma VEGF Modify the Systemic Microcirculation?....Pages 147-153 Impact of Environmental Parameters on the Activity of the P-Glycoprotein....Pages 155-160 3-D High-Resolution Mapping of the Heterogeneity in Mitochondrial Redox State of Human Breast Tumor Xenografts....Pages 161-167 High-Resolution Simultaneous Mapping of Mitochondrial Redox State and Glucose Uptake in Human Breast Tumor Xenografts....Pages 169-174 Front Matter....Pages 175-179 Regulation of Oxygen Delivery by the Reaction of Nitrite with RBCs Under Hypoxic Conditions....Pages 181-181 Clinical Applications of Tissue Oxygen Saturation Measurements....Pages 183-189 Oscillations in Cardiac Output in Hypoxia with Periodic Breathing and Constant End-Tidal PCO 2 at High Altitude (5,000 m)....Pages 191-196 The Relationship of Acute Mountain Sickness to Arterial Oxygen Saturation at Altitudes of 3,324 to 5,176 m....Pages 197-206 Effects of Acute Anemia and Hyperoxia on Oxygen Distribution....Pages 207-212 Front Matter....Pages 213-218 Monitoring Cardiopulmonary Function and Progression Toward Shock: Oxygen Micro-sensor for Peripheral Tissue....Pages 219-219 Whole Body Oxygen Delivery and Consumption During Cardiopulmonary Bypass Surgery....Pages 221-227 Pharmacologic Interventions to Improve Splanchnic Oxygenation During Ventilation with Positive End-Expiratory Pressure....Pages 229-234 Effect of Pneumoperitoneum on Functional Residual Capacity....Pages 235-238 Estimation of Molecular Hydrogen Consumption in the Human Whole Body After the Ingestion of Hydrogen-Rich Water....Pages 239-243 Prenylated Acylphloroglucinol Derivatives: Isoprenomics-Based Design, Syntheses and Antioxidative Activities....Pages 245-250 Front Matter....Pages 251-256 Retrograde Perfusion of the Hind Leg in Diabetic Patients Suffering from Arteriosclerosis Obliterans: Theoretical Considerations of Oxygen Supply and Lymphatic Flow Based on Rat Models....Pages 257-257 Triplet Imaging of Oxygen Consumption During the Contraction of a Single Smooth Muscle Cell (A7r5)....Pages 259-262 Relationship Between Submaximal Handgrip Muscle Force and NIRS-Measured Motor Cortical Activation....Pages 263-268 Front Matter....Pages 269-274 Feasibility Study of Non-invasive Oxygenation Measurement in a Deep Blood Vessel Using Acousto-Optics and Microbubbles....Pages 275-275 Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles....Pages 277-283 Development of a Model to Aid NIRS Data Interpretation: Results from a Hypercapnia Study in Healthy Adults....Pages 285-291 Boron Tracedrug: Design, Synthesis, and Pharmacological Activity of Phenolic BODIPY-Containing Antioxidants as Traceable Next-Generation Drug Model....Pages 293-300 Modelling and Filtering of Physiological Oscillations in Near-Infrared Spectroscopy by Time-Varying Fourier Series....Pages 301-306 Back Matter....Pages 307-313 ....Pages 315-322