Oxygen Transport to Tissue XXXII (Advances in Experimental Medicine and Biology, 701)

Based on the 2009 proceedings of the 37th annual ISOTT conference, this volume covers all aspects of oxygen delivery to tissue, everything from near infrared spectroscopy, tumor biology, angiogenesis and mitochondrial metabolism to systems modeling, gas transport, hypoxic adaptation and exercise physiology. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biological bases for pathology related to tissue oxygenation. This multidisciplinary volume includes contributions from scientists, engineers, clinicians and mathematicians and is aimed and students and experts from a range of research fields. pt. 1. Near infrared spectroscopy. The Western Reserve, Edward Morley, and oxygen / Joseph C. LaManna Analysis of the changes in the oxidation of brain tissue cytochrom-c-oxidase in traumatic brain injury patients during hypercapnoea / Ilias Tachtsidis ... [et al.] Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva manoeuvre / Lei Gao ... [et al.] Speech therapy changes blood circulation and oxygenation in the brain and muscle / Martin Woilf, Dietrich von Bonin, and Ursula Wolf pt. 2. Oxygen sensors and measurement. Evaluation of lithium naphthalocyanine (LiNc) microcrystals for biological EPR oximetry / Ramasamy P. Pandian ... [et al.] Challenges to intestinal pO2 measurement using EPR / Elaine Fisher ... [et al.] Quantification of systemic interference in optical topography data during frontal lobe and motor cortex activation: an independent component analysis / Sundeep Patel ... [et al.] Measuring oxygen in live tissue: intravascular, interstitial, and "tissue" oxygen measurements / David F. Wilson ... [et al.] Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonators / Huagang Hou ... [et al.] 31P-MRS studies of melanoma xenografts with different metastatic potential / Lin Z. Li ... [et al.] Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy / Zrinka Abramovic ... [et al.] pt. 3. Blood and blood substitutes. MP4, a vasodilatory PEGylated hemoglobin / Russell H. Cole and Kim D. Vandegriff Zymogen protein C to prevent clotting without bleeding during invasive medical procedures / Duane F. Bruley, Sanjay B. Jagannath, and Michael B. Streiff pt. 4. Tumor biology. Oxygenation status of urogenital tumors / Peter Vaupel, Michael Hoeckel, and Arnulf Mayer Tumor pO2 as a surrogate marker to identify therapeutic window during metronomic chemotherapy of 9L gliomas / Sriram Mupparaju ... [et al.] Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in Vivo via p38 signaling pathway / Oliver Thews ... [et al.] Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells / Arnulf Mayer, Angelika von Wallbrunn, and Peter Vaupel NMR metabolic and physiological markers of therapeutic response / Seung-Cheol Lee ... [et al.] Characterizing breast cancer mouse xenografts with T1[rho]-MRI / Lin Z. Li, He N. Xu, and Ravinder Reddy Effect of AEM energy applicator configuration on magnetic nanoparticle mediated hyperthermia for breast cancer / Krishna K. Sanapala, Kapila Hewaparakrama, and Kyung A. Kang Highly specific, NIR fluorescent contrast agent with emission controlled by gold nanoparticle / Jianting Wang ... [et al.] pt. 5. Presidential symposium. Oral pioglitazone reduces infarction volume and improves neurologic function following MCAO in rats / D'Arbra Blankenship ... [et al.] pt. 6. Angiogenesis. Chronic mild hypoxia ameliorates chronic inflammatory activity in myelin oligodendrocyte glycoprotein (MOG) peptide induced experimental autoimmune encephalomyelitis (EAE) / Paula Dore-Duffy ... [et al.] Effect of oxygenation on stem-cell therapy for myocardial infarction / Mahmood Khan ... [et al.] pt. 7. Mitochondiral metabolism. Regulation of cytosolic and mitochondrial oxidation via malate-asparate shuttle: an observation using dynamic 13C NMR spectroscopy / Ming Lu ... [et al.] In vivo assessment of oxygen consumption via deuterium magnetic resonance / Gheorghe D. Mateescu ... [et al.] Elevated mitochondrial DNA copy number and POL-[gamma] expression but decreased expression of TFAM in murine intestine following therapeutic dose irradiation / Hengshan Zhang ... [et al.] Heterogeneity of mitochondrial redox state in premalignant pancreas in a PTEN null transgenic mouse model / He N. Xu ... [et al.] Potential application of 17O MRI to human ischemic stroke / Robert DeLaPaz and Pradeep Gupte pt. 8. Development. Fetal cerebral oxygenation: the homeostatic role of vascular adaptations to hypoxic stress / William J. Pearce ... [et al.] Impaired cerebral autogregulation using near-infrared spectroscopy and its relation to clinical outcomes in premature infants / Alexander Caicedo ... [et al.] pt. 9. Systems modeling. Variable ATP yields and uncoupling of oxygen consumption in human brain / Albert Gjedde ... [et al.] Interpretation of NMR spectroscopy human brain data with a multi-compartment computational model of cerebral metabolism / Rossana Occhipinti, Erkki Somersalo, and Daniela Calvetti Regional brain blood flow in mouse: quantitative measurement using a single-pass radio-tracer method and a mathematical algorithm / K. Xu ... [et al.] pt. 10. Microcirculation and wound healing. Wound healing in diabetes: hemorheological and microcirculatory aspects / Giuseppe Cicco, Francesco Giorgino, and Sebastiano Cicco Modeling O2-dependent effects of nitrite reductase activity in blood and tissue on coupled NO and O2 transport around arterioles / Donald G. Buerk, Kenneth A. Barbee, and Dov Jaron Skin SO2 measurement using visible lightguide spectrophotometry in a black population: a feasibility study / David K. Harrison, André R. Greenidge, and R. Clive Landis Antioxidant properties of quercetin / Mei Zhang ... [et al.] Antioxidant properties of select radiation mitigators based on semicarbazone and pyrazole derivatives of curcumin / Steven G. Swarts ... [et al.] pt. 11. Gas transport. Impact or intracellular diffusion of oxygen in hypoxic sensing / Eiji Takahashi and Michihiko Sato Micropores in the vitteline layer of the eggs of the dragonfly Oligaoeshna pryeri: a preliminary observation from the viewpoint of oxygen uptake / Tomiyasu Koyama, Hiroko Takano, and Tohru Yokoyama pt. 12. Hypoxic adaptation. A heat-shock protein co-inducer treatment improves behavioral performance in rats exposed to hypoxia / Kui Xu ... [et al.] Chronic intermittent hypoxia-induced augmented cardiorespiratory outflow mediated by vasopressin-V1[A] receptors signaling in the medulla / Prabha Kc ... [et al.] Effect of inspiration of 12%O2 (balance N2) on cardiac output, respiration, oxygen saturation, and oxygen delivery / M. Bell, C.D. Thanke, and C.B. Wolff pt. 13. Exercise physiology. Sufficient oxygen can be transported to resting skeletal muscle via arterialization of the vein: theoretical considerations in a rat model / Tomiyasu Koyama and Tomiyasu Koyama Skeletal muscle perfusion and oxygenation assessed by dynamic NMR imaging and spectroscopy / P.G. Carlier Hemoglobin and myoglobin contributions to skeletal muscle oxygenation in response to exercise / Jessica Spires ... [et al.] Estimation of muscle fatigue using surface electromyography and near-infrared spectroscopy / Joachim Taelman ... [et al.]. Front Matter....Pages i-xxx Front Matter....Pages 1-1 The Western Reserve, Edward Morley, and Oxygen....Pages 3-8 Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea....Pages 9-14 Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre....Pages 15-20 Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle....Pages 21-25 Front Matter....Pages 27-27 Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR Oximetry....Pages 29-36 Challenges to Intestinal pO 2 Measurement Using EPR....Pages 37-44 Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis....Pages 45-51 Measuring Oxygen in Living Tissue: Intravascular, Interstitial, and “Tissue” Oxygen Measurements....Pages 53-59 Cerebral Oxygenation of the Cortex and Striatum Following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators....Pages 61-67 31 P-MRS Studies of Melanoma Xenografts with Different Metastatic Potential....Pages 69-73 Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing Therapy....Pages 75-82 Front Matter....Pages 83-83 MP4, a Vasodilatory PEGylated Hemoglobin....Pages 85-90 Zymogen Protein C to Prevent Clotting without Bleeding during Invasive Medical Procedures....Pages 91-97 Front Matter....Pages 99-99 Oxygenation Status of Urogenital Tumors....Pages 101-106 Tumor pO 2 as a Surrogate Marker to Identify Therapeutic Window during Metronomic Chemotherapy of 9L Gliomas....Pages 107-113 Hypoxia-Induced Extracellular Acidosis Increases p-Glycoprotein Activity and Chemoresistance in Tumors in Vivo via p38 Signaling Pathway....Pages 115-122 Evidence against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells....Pages 123-128 NMR Metabolic and Physiological Markers of Therapeutic Response....Pages 129-135 Characterizing Breast Cancer Mouse Xenografts with T 1ρ -MRI....Pages 137-142 Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer....Pages 143-148 Front Matter....Pages 99-99 Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle....Pages 149-154 Front Matter....Pages 155-155 Oral Pioglitazone Reduces Infarction Volume and Improves Neurologic Function Following MCAO in Rats....Pages 157-162 Front Matter....Pages 163-163 Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE)....Pages 165-173 Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction....Pages 175-181 Front Matter....Pages 183-183 Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13 C NMR Spectroscopy....Pages 185-192 In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance....Pages 193-199 Elevated Mitochondrial DNA Copy Number and POL- γ Expression but Decreased Expression of TFAM in Murine Intestine Following Therapeutic Dose Irradiation....Pages 201-206 Heterogeneity of Mitochondrial Redox State in Premalignant Pancreas in a PTEN Null Transgenic Mouse Model....Pages 207-213 Potential Application of 17 O MRI to Human Ischemic Stroke....Pages 215-222 Front Matter....Pages 223-223 Fetal Cerebral Oxygenation: The Homeostatic Role of Vascular Adaptations to Hypoxic Stress....Pages 225-232 Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and Its Relation to Clinical Outcomes in Premature Infants....Pages 233-239 Front Matter....Pages 241-241 Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain....Pages 243-248 Interpretation of NMR Spectroscopy Human Brain Data with a Multi-Compartment Computational Model of Cerebral Metabolism....Pages 249-254 Regional Brain Blood Flow in Mouse: Quantitative Measurement Using a Single-Pass Radio-Tracer Method and a Mathematical Algorithm....Pages 255-260 Front Matter....Pages 261-261 Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects....Pages 263-269 Modeling O 2 -Dependent Effects of Nitrite Reductase Activity in Blood and Tissue on Coupled NO and O 2 Transport around Arterioles....Pages 271-276 Skin SO 2 Measurement Using Visible Lightguide Spectrophotometry in a Black Population: A Feasibility Study....Pages 277-282 Antioxidant Properties of Quercetin....Pages 283-289 Antioxidant Properties of Select Radiation Mitigators Based on Semicarbazone and Pyrazole Derivatives of Curcumin....Pages 291-297 Front Matter....Pages 299-299 Impact of Intracellular Diffusion of Oxygen in Hypoxic Sensing....Pages 301-306 Front Matter....Pages 299-299 Micropores in the Vitteline Layer of the Eggs of the Dragonfly Oligoaeshna pryeri : A Preliminary Observation from the Viewpoint of Oxygen Uptake....Pages 307-310 Front Matter....Pages 311-311 A Heat-Shock Protein Co-Inducer Treatment Improves Behavioral Performance in Rats Exposed to Hypoxia....Pages 313-318 Chronic Intermittent Hypoxia-Induced Augmented Cardiorespiratory Outflow Mediated by Vasopressin-V 1A Receptor Signaling in the Medulla....Pages 319-325 Effect of Inspiration of 12%O 2 (Balance N 2 ) on Cardiac Output, Respiration, Oxygen Saturation, and Oxygen Delivery....Pages 327-332 Front Matter....Pages 333-333 Sufficient Oxygen Can Be Transported to Resting Skeletal Muscle via Arterialization of the Vein: Theoretical Considerations in a Rat Model....Pages 335-339 Skeletal Muscle Perfusion and Oxygenation Assessed by Dynamic NMR Imaging and Spectroscopy....Pages 341-346 Hemoglobin and Myoglobin Contributions to Skeletal Muscle Oxygenation in Response to Exercise....Pages 347-352 Estimation of Muscle Fatigue Using Surface Electromyography and Near-Infrared Spectroscopy....Pages 353-359 Erratum to: Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain....Pages E1-E3 Erratum....Pages E5-E6 Back Matter....Pages 361-368

This book covers the proceedings of the 32nd scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) in Bari, Italy, August 21-26, 2004. It covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. The event hosted was a multidisciplinary meeting designed to bring together experts and students from a range of research fields.

This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.