Oxygen Transport to Tissue XXVIII (Advances in Experimental Medicine and Biology) (Advances in Experimental Medicine and Biology)

At the beginning of a Southern Hemisphere Autumn, the ISOTT tribe assembled for its annual corroboree on the banks of the Brisbane River in Australia for five days of exciting science. Some of the tribe had travelled from as far as Sweden and other parts of Europe; many had spirited themselves across the Pacific Ocean from the Americas. Yet another small contingent had paddled down from Japan. All came with message sticks from their camp-sites. The conference opened with an outdoor barbecue at the Southbank precinct, with the stars of the Southern Cross painting the river on one side and the artificial beach on the other; a perfect venue to meet old friends and to welcome new ones as a cool breeze wafted over our fires. For the next five days there was the usual focus on oxygen; measurement techniques, its role in cancer and other diseases that beset us mortals and the biochemistry and physiology of this small vital molecule. It still astounds many that we have not yet learnt everything there is to know about this valuable friend, albeit a dangerous foe. Time was found for us to visit Australia Zoo and stand in awe before exhibits of Australia’s wild-life; great vicious creatures unchanged from the age of the dinosaurs, poisonous snakes and spiders, and gentle marsupials that posed for our digital cameras. Anticoagulant blood factor deficiencies (protein C) / Duane F. Bruley Hemorheological aspects in the microvasculature of several pathologies / Giuseppe Cicco and Sebastiano Cicco Clonidine elecits a long-term depression in mucosal red cell flux / Artur Fournell ... [et al.] Real-time, automated, fluorophore mediated multi-cardiac marker biosensing system with nano-metallic particle reagent / Bin Hong ... [et al.] PTEN and NDUFB8 aberrations in cervical cancer tissue / S. M. Hsieh ... [et al.] Prediction of surgical site infections after major surgery using visible and near-infrared spectroscopy / Charlotte L. Ives, D. K. Harrison, and G. S. Stansby Application of novel metal nanoparticles as optical/thermal agents in optical mammography and hyperthermic treatment for breast cancer / Hanzhu Jin and Kyung A. Kang Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase®, on A549 human lung cancer xenografts of nude mice / Dae Hong Kim ... [et al.] Effect of pH and imidazole on protein purification from Cohn fraction IV-1 by IMAC / James J. Lee, Duane F. Bruley and Kyung A. Kang Predicting melanoma metastatic potential by optical and magnetic resonance imaging / LinX. J. Li ... [et al.] Analysis of SDHS and MMP12 in an affected solar keratosis and control cohort / N. A. Lintell ... [et al.] Wyman's equation and oxygen flux through the red cell / Michael McCabe and David J. Maguire Simultaneous measurement of pO2 and perfusion in the rabbit kidney in vivo / Paul M. O'Connor ... [et al.] Pseudogenes and the electron transport chain / H. M. Oey, D. J. Maguire and M. McCabe Intratumoral VEGF and FGF1 administration alters tumor growth, vascular density, oxygenation, and expression of MCP-1 and interleukins / Paul Okunieff ... [et al.] Nitric oxide in the kidney; direct measurements of bioavailable renal nitric oxide / Fredrik Palm, Lina Nordquist and Donald G. Buerk Separation of protein C from COHN fraction IV-2 by mini-antibody / Samin Rezania, Doh G. Ahn and Kyung A. Kang The role of ATP sensitive channels in insulin secretion and the implications in persistent hyperinsulinemic hypoglycaemia in infancy (PHHI) / J. H. Shan ... [et al.] Triptolide alters mitochondrial functions / Ying Su ... [et al.] Immunohistochemical identification and localization of endogenous endostatin and its related peptides in murine tumors / Jianzhong Sun ... [et al.] Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs / Oliver Thews ... [et al.] Brief exposure to-2Gz reduces cerebral oxygenation in response to stand test / Cong C. D. Tran [et al.] Normal cardiac output, oxygen delivery and oxygen extraction / Christopher B. Wolff Near infra-red spectroscopy and arterial oxygen extraction at altitude / Christopher B. Wolff ... [et al.] Oxygen delivery at sea level and altitude (after slow ascent to 5000 meters), at rest and in mild exercise / Christopher B. Wolff ... [et al.] Increased sensitivity to transient global ischemia in aging rat brain / Kui Xu ... [et al.] Single breath tracing for carbon dioxide in septic patients with tissue hypoxia / Renzo Zatelli. Front Matter....Pages I-XIV Anticoagulant Blood Factor Deficiencies (Protein C)....Pages 1-6 Hemorheological Aspects in The Microvasculature of Several Pathologies....Pages 7-15 Clonidine Elicits A Long-Term Depression in Mucosal Red Cell Flux....Pages 17-22 Real-Time, Automated, Fluorophore Mediated Multi-Cardiac Marker Biosensing System with Nano-Metallic Particle Reagent....Pages 23-29 Pten and Ndufb8 Aberrations in Cervical Cancer Tissue....Pages 31-36 Prediction Of Surgical Site Infections After Major Surgery Using Visible And Near-Infrared Spectroscopy....Pages 37-44 Application Of Novel Metal Nanoparticles As Optical/Thermal Agents In Optical Mammography And Hyperthermic Treatment For Breast Cancer....Pages 45-52 Possible Mechanisms Of Improved Radiation Response By Cytotoxic Rnase, Onconase®, On A549 Human Lung Cancer Xenografts Of Nude Mice....Pages 53-59 Effect Of Ph And Imidazole On Protein C Purification From Cohn Fraction Iv-1 By Imac....Pages 61-66 Predicting Melanoma Metastatic Potential By Optical And Magnetic Resonance Imaging....Pages 67-78 Analysis of Sdhd and Mmp12 in an Affected Solar Keratosis and Control Cohort....Pages 79-85 Wyman’s Equation and Oxygen Flux Through The Red Cell....Pages 87-92 Simultaneous Measurement of pO 2 and Perfusion in The Rabbit Kidney in Vivo....Pages 93-99 Pseudogenes and The Electron Transport Chain....Pages 101-107 Intratumoral Vegf and Fgf1 Administration Alters Tumor Growth, Vascular Density, Oxygenation, and Expression of Mcp-1 and Interleukins....Pages 109-116 Nitric Oxide in The Kidney Direct measurements of bioavailable renal nitric oxide....Pages 117-123 Separation Of Protein C From Cohn Fraction Iv-1 By Mini-Antibody....Pages 125-131 The Role of ATP Sensitive Channels in Insulin Secretion and The Implications in Persistent Hyperinsulinemic Hypoglycaemia of Infancy (PHHI)....Pages 133-138 Triptolide Alters Mitochondrial Functions....Pages 139-146 Immunohistochemical Identification And Localization Of Endogenous Endostatin And Its Related Peptides In Murine Tumors....Pages 147-153 Impact Of Hypoxic And Acidic Extracellular Conditions On Cytotoxicity Of Chemotherapeutic Drugs....Pages 155-161 Brief Exposure To –2 G Z Reduces Cerebral Oxygenation In Response To Stand Test....Pages 163-168 Normal Cardiac Output, Oxygen Delivery And Oxygen Extraction....Pages 169-182 Near Infra-Red Spectroscopy And Arterial Oxygen Extraction At Altitude....Pages 183-189 Oxygen Delivery at Sea Level and Altitude (After Slow Ascent to 5000 Meters), at Rest and in Mild Exercise....Pages 191-197 Increased Sensitivity to Transient Global Ischemia in Aging Rat Brain....Pages 199-206 Single Breath Tracing for Carbon Dioxide in Septic Patients with Tissue Hypoxia....Pages 207-212 Back Matter....Pages 213-216 This multidisciplinary book covers a wealth of topics, all related to the delivery of oxygen to tissue. Readers will find in its pages material and information on blood flow and its regulation as well as oxygen metabolism. This wealth of subject matter is based on the papers and discussion at the 33rd Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) held in Australia in 2005. Special attention here is paid to methods of oxygen measurement in living tissue and the application of these technologies to understanding the physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and thus is designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology Covers the aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism as discussed at the 33rd Annual Meeting of the International Society on Oxygen Transport to Tissue, held in August 2005. Special attention is paid to methods of oxygen measurement in living tissue