Oxygen Transport to Tissue XXVI (Advances in Experimental Medicine and Biology Book 566)

The International Society of Oxygen Transport to Tissue (ISOTT) was founded in 1973 to provide a forum for bioengineers, basic scientists, physiologists, and physicians to discuss new data, original theories, new interpretations of old data, and new technologies for the measurement of oxygen. At each annual meeting all posters are presented orally along with plenary lectures, and all presentations are given in a general session attended by everyone. Each meeting has had a specific focus, ranging from neonatology to physical chemistry to cancer biology. The Society has helped to build many careers, through opportunities to meet leaders in the field, and through awards made to young physicians and scientists. The Society also, through cross fertilization of ideas and scientific comradery, has inspired many breakthroughs in clinical medicine that now benefit mankind. I find myself president of the society after having been a winner of the Melvin Knisely Award for young scientists, in 1991. The 2003 meeting emphasized the role of oxygen and oxygen measurement in tumor growth, metastasis, physiology, and treatment resistance. Additionally, however, completely novel approaches to measurement of tissue oxygen were presented (notably work by Dr. Takahashi) and molecular methods for estimating tissue oxygen were evaluated. Papers discussing other aspects of oxygen measurement and pathophysiology were presented including in vivo ESR spectroscopy (notably including Dr. Swartz and colleagues), exercise physiology, organ transplant outcome (discussed by Dr. Cicco, our 2004 president), circulatory physiology, and cerebral oxygenation (notably including Dr. Chance). Cerebral Oxygenation During Repetitive Apnea in Newborn Piglets....Pages 1-7 Optimal Determination of Detector Placement in Cerebral NIR Spectroscopy of Neonates Using Chemometric Techniques....Pages 9-15 Simulation Study of Breast Tissue Hemodynamics During Pressure Perturbation....Pages 17-22 Microvascular Oxygenation and Oxidative Stress During Postischemic Reperfusion....Pages 23-29 Hypoxia, Tumor Endothelium, and Targets for Therapy....Pages 31-38 Genetic Oxygen Sensor....Pages 39-44 Effects of Insulin and Catecholamines on Inotropy and Oxygen Uptake....Pages 45-50 Adaptation to Chronic Hypoxia During Diet-Induced Ketosis....Pages 51-57 Varied Response of Spontaneous Tumors to Antiangiogenic Agents....Pages 59-65 Non-Invasive Measurement of Tumor Oxygenation Using Embedded Microparticulate EPR Spin Probe....Pages 67-73 The Effects of Tumour Blood Flow and Oxygenation Modifiers on Subcutaneous Tumours as Determined by NIRS....Pages 75-81 Hyperthermia and Hypermetabolism in Focal Cerebral Ischemia....Pages 83-89 Variability of Cerebral Hemoglobin Concentration in Very Preterm Infants During the First 6 Hours of Life....Pages 91-97 Computational Study on Use of Single-Point Analysis Method for Quantitating Local Cerebral Blood Flow in Mice....Pages 99-104 Effects of Temperature on Oxygen Transport in Sheets and Spheres of Respiring Tissues....Pages 105-109 Modeling of the Response of p t O 2 in Rat Brain to Changes in Physiological Parameters....Pages 111-118 Black Magic and EPR Oximetry....Pages 119-125 Axial Oxygen Diffusion in the Krogh Model....Pages 127-134 Differentiating Hemodynamic Compromise by the OEF Response to Acetazolamide in Occlusive Vascular Disease....Pages 135-141 The Anomalous Einstein-Stokes Behaviour of Oxygen and Other Low Molecular Weight Diffusants....Pages 143-149 Gut Dysoxia....Pages 151-157 Imaging Oxygen Pressure in the Retina of the Mouse Eye....Pages 159-165 Fluorescence-Mediated Detection of a Heterogeneity in a Highly Scattering Media....Pages 167-172 Developing Strategies for Three-Dimensional Imaging of Oxygen Tension in the Rodent Retina....Pages 173-178 Cerebral PtO 2 , Acute Hypoxia, and Volatile Anesthetics in the Rat Brain....Pages 179-185 Rate of Change in Cerebral Oxygenation and Blood Pressure in Response to Passive Changes in Posture....Pages 187-193 Validation of the Cas Neonatal NIRS System by Monitoring VV-ECMO Patients....Pages 195-201 Interactions between HIF-1 and Jab1: Balancing Apoptosis and Adaptation....Pages 203-211 Past, Present, and Future of Oxygen in Cancer Research....Pages 213-222 Benzoate Hydroxylation....Pages 223-229 Mitochondrial NADH as the Bellwether of Tissue O 2 Delivery....Pages 231-242 Process Scale-Up Studies for Protein C Separation Using IMAC....Pages 243-248 Hypoxia-Induced Alterations in Hyaluronan and Hyaluronidase....Pages 249-256 Rate of Decrease of PO 2 from an Arteriole with Arrested Flow....Pages 257-262 Measurement of CMRO 2 in Neonates Undergoing Intensive Care Using Near Infrared Spectroscopy....Pages 263-268 The Pathways of Oxygen in Brain I....Pages 269-275 The Pathways of Oxygen in Brain II....Pages 277-283 Exogenous and Endogenous Markers of Tumour Oxygenation Status....Pages 285-294 The Difficulties in Comparing In Vivo Oxygen Measurements....Pages 295-301 Preliminary Study of Simultaneous Multi-Anticoagulant Deficiency Diagnosis by Fiber Optic Multi-Analyte Biosensor....Pages 303-309 Circulation Time in Man from Lung to Periphery as an Indirect Index of Cardiac Output....Pages 311-316 Factors Controlling Oxygen Utilization....Pages 317-323 Amputation Level Viability in Critical Limb Ischaemia....Pages 325-331 Hypoxia in Breast Cancer....Pages 333-342 Monitoring Metabolite Gradients in the Blood, Liver, and Tumor after Induced Hyperglycemia in Rats with R3230 Flank Tumors Using Microdialysis and Bioluminescence Imaging....Pages 343-348 Possible Protective Effects of α-Tocopherol on Enhanced Induction of Reactive Oxygen Species by 2-Methoxyestradiol in Tumors....Pages 349-355 Simultaneous NIR-EPR Spectroscopy of Rat Brain Oxygenation....Pages 357-362 Microcirculation and Reperfusion Injury in Organ Transplantation....Pages 363-373 Focussing on Genomic and Phenomic Correlations in Respiration of Non-Melanotic Skin Cancers....Pages 375-380 Protein C Production....Pages 381-387 Modeling Behavior of Protein C during and after Subcutaneous Administration....Pages 389-395 Echanisms for Vasoconstriction and Decreased Blood Flow Following Intravenous Administration of Cell-Free Native Hemoglobin Solutions....Pages 397-401 Edited By Paul Okunieff, Jacqueline Williams, Yuhchyau Chen. Proceedings Of The Thirty-first Scientific Meeting Of The International Society On Oxygen Transport To Tissue (isott), Held August 16-20, 2003 At The University Of Rochester In Rochester, Ny, Usa--t.p. Verso. Includes Bibliographical References And Indexes. Covers various aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology