Oxygen Transport To Tissue XXIII: Oxygen Measurements in the 21st Century: Basic Techniques and Clinical Relevance (Advances in Experimental Medicine and Biology, 510)

The ISOTT 2001 local organizing committee was pleased to welcome over 140 delegates from around the world to the 29th annual general meeting of the International Society for Oxygen Transport to Tissue. The meeting was held in historic Philadelphia, USA, on the campus of the University of Pennsylvania from August 11 to 15, 2001. In the tradition of ISOTT, the conference was a total immersion experience. Attendees were encouraged to eat together and spend their evenings relaxing together in a style that maximized exchange of ideas and interactions of younger scientists with their more senior colleagues. Delegates participated in a total of 122 presentations including poster displays, selected oral presentations, seminars by invited speakers and a round table discussion. In choosing invited speakers and oral presenters, special emphasis was placed on methods for oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. All of the manuscripts contained in this volume underwent both an editorial and scientific review, and only those meeting both criteria have been published. However, while all efforts have been made to eliminate editorial errors, some have undoubtedly been overlooked, for which the editors apologize. Front Matter....Pages i-xviii The Role of Tumor Oxygenation in Vascular and Clinical Response to Angiogenesis Inhibition....Pages 1-5 Comparison of Fluctuations of Oxygen Tension in FSA, 9L, and R3230AC Tumors in Rats....Pages 7-12 Effect of Carbogen-Breathing on Redox Status of the RIF-1 Tumor....Pages 13-17 Evaluation of Microregional Variations in Tumor Hypoxia Following the Administration of Endostatin....Pages 19-24 Effect of Hydralazine on Blood Flow, Oxygenation, and Interstitial Fluid Pressure in Subcutaneous Tumors....Pages 25-29 Oxygenation of Cervix Cancers: Impact of Clinical and Pathological Parameters....Pages 31-35 Quantitative Spatial Analysis of Hypoxia and Vascular Perfusion in Tumor Sections....Pages 37-43 Tumor Oxygenation and Its Relevance to Tumor Physiology and Treatment....Pages 45-49 Mechanisms Underlying Hypoxia Development in Tumors....Pages 51-56 Lack of Association Between Tumor Hypoxia, Glut-1 Expression and Glucose Uptake in Experimental Sarcomas....Pages 57-61 The Impact of Tissue Microenvironment on Treatment Simulation....Pages 63-67 Evidence for and Against Hypoxia as the Primary Cause of Tumor Aggressiveness....Pages 69-75 Characterization of Human Gc Protein- Derived Macrophage Activation Factor (GcMAF) and Its Functional Role in Macrophage Tumoricidal Activity....Pages 77-82 Effect of Hemoglobin Solutions as Hemodiluents on Capillary Oxygen Tension....Pages 83-88 Different Efficacy in Vitro of Hemoglobin Based Oxygen Carriers and Red Cells....Pages 89-92 A Novel Blood Transfusant Candidate: Intact Human Erythrocytes Containing Hemoglobin Exclusively Nitrosylated in the α-Subunits....Pages 93-99 The Contribution of Hemoglobin to Oxygen Transport in the Microcrustacean Daphnia Magna ....Pages 101-107 Modifications of Red Blood Cell Shape and Glycoproteins Membrane Content in Septic Patients....Pages 109-114 Fiber Optic Immunosensors for Cardiovascular Disease Diagnosis....Pages 115-119 Soft Gel Chromatography Column Analysis and Design for the Production of High Molecular Weight Blood Factors: Model Molecule Protein C....Pages 121-125 Development of an Economic Miniantibody Production Process for the Purification of Protein C (Anti-Coagulant/Anti-Thrombotic)....Pages 127-131 Nitric Oxide Synthesis in Brain is Stimulated By Oxygen....Pages 133-137 Oxygen Indirectly Regulates Nitric Oxide Availability....Pages 139-143 Modeling the Regulation of Oxygen Consumption By Nitric Oxide....Pages 145-149 Oxygen Sensor Design: Analysis and Correction of Problems Associated with Zero Current, Stability and Structure....Pages 151-156 Computer Simulation of Oxygen Microelectrode Measurements in Tissues....Pages 157-161 Physiological Oxygen Measurements Using Oxygen Electrodes....Pages 163-167 Accuracy of a Polarographic Electrode at High Oxygen Concentrations....Pages 169-173 Recessed Oxygen Electrodes: Getting More Than PO 2 ....Pages 175-179 Oxygen Distributions in Tissue Measured by Phosphorescence Quenching....Pages 181-185 Adapting and Validating a NIRS Device to Measure in Utero Fetal Sheep Cerebral Oxygenation....Pages 187-192 Detection of the Fast Neuronal Signal on the Motor Cortex Using Functional Frequency Domain near Infrared Spectroscopy....Pages 193-197 Probing Rat Brain Oxygenation with Near-Infrared Spectroscopy (NIRS) and Magnetic Resonance Imaging (MRI)....Pages 199-204 Variation in Blood Oxygenation and Cerebral pO 2 in a Mouse Model Measured by EPR Spectrometry....Pages 205-211 Functional Oxygen-17 Magnetic Resonance Imaging and Localized Spectroscopy....Pages 213-218 Development of a Retractor for Monitoring the Oxygenation State of Brain Tissue....Pages 219-223 Mapping of Hemodynamics on the Human Calf with Near Infrared Spectroscopy and the Influence of the Adipose Tissue Thickness....Pages 225-230 EPR Imaging of Vascular Changes in Oxygen in Response to Carbogen Breathing....Pages 231-236 Molecular Imaging by PET....Pages 237-241 Frequency Domain Imaging of Oxygen Tension in the Mouse Retina....Pages 243-247 Oxygen Delivery to the Retina and Related Visual Pathology....Pages 249-254 Activation of the Visual Cortex in Newborn Infants Under Natural Sleep Using Multichannel Near-Infrared Spectroscopy....Pages 255-259 Effect of Blood Flow on PvO 2 -VO 2 Relation in Contracting In Situ Skeletal Muscle....Pages 261-265 Oxygen Transport and Intracellular Bioenergetics on Stimulated Cat Skeletal Muscle....Pages 267-272 Muscle Oxygenation by Near Infrared Spectroscopy and Lactate Thresholds in Endurance Trained and Recreationally Active Cyclists....Pages 273-278 Cardiac Output, Oxygen Consumption and Muscle Oxygen Delivery in Submaximal Exercise....Pages 279-284 Non-Invasive PET and Spect Imaging of Tissue Hypoxia Using Isotopically Labeled 2-Nitroimidazoles....Pages 285-292 Diffuse Optical Measurement of Hemoglobin and Cerebral Blood Flow in Rat Brain During Hypercapnia, Hypoxia and Cardiac Arrest....Pages 293-297 Multiorgan Monitoring of Hemodynamic and Mitochondrial Responses to Anoxia and Cardiac Arrest in the Rat....Pages 299-304 Importance of Glomus Cell Plasma Membrane and Mitochondrial Membrane Potentials During Acute Hypoxia Signaling in the Rat Carotid Body....Pages 305-311 Estimation of Hydroxyl Radicals Based on the Salicylate Trapping Method in Hippocampus of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) During Transient Ischemia and Recirculation....Pages 313-317 Effect of Hypoxia and Ischemia on Expression of Selected Genes in Brain of Newborn Piglets....Pages 319-324 Brain Oxygenation During Cardiopulmonary Bypass and Circulatory Arrest....Pages 325-330 Expression of Angiopoietin-1 and -2 in the Rat Brain During Chronic Hypoxia and De-Adaptation....Pages 331-335 Hypoxia-Inducible Factor-1α Accumulation in the Rat Brain in Response to Hypoxia and Ischemia is Attenuated During Aging....Pages 337-341 Lung Ischemia: Endothelial Cell Signaling by Reactive Oxygen Species....Pages 343-347 Near Infrared Spectroscopy (NIRS) Measurements During Global Cerebral Ischemia in Sheep....Pages 349-354 Simulations of Capillary Network Oxygen Transport During Transient Ischemia in the Presence and Absence of Tissue Myoglobin....Pages 355-359 Cerebral Oxygenation During Chronic Obstructive Pulmonary Disease....Pages 361-364 Physiology of Functional Activation....Pages 365-368 Nonlinear Analysis of Heart Rate Variability in Infants with Apparent Life- Threatening Events....Pages 369-373 The Effect of Nicotinamide & Hyperoxic Gases on Blood Glucose....Pages 375-378 Measurement of Tissue Oxygenation Index During the First Three Days in Premature Born Infants....Pages 379-383 Simultaneous Measurement of Cerebral Tissue Oxygenation over the Adult Frontal and Motor Cortex During Rest and Functional Activation....Pages 385-389 Dysfunctional Microvascular Conducted Response in Irradiated Normal Tissue....Pages 391-395 Oxygenation and Blood Concentration Changes in Human Subject Prefrontal Activation by Anagram Solutions....Pages 397-401 Quantitation of the Concordance Between Cerebral Intravascular Oxygenation and Mean Arterial Blood Pressure for the Detection of Impaired Autoregulation....Pages 403-408 Effects of Fluid Percussion Injury on Rat Brain Hemodynamics, Ionic, Electrical Activity, and Energy Metabolism in Vivo ....Pages 409-414 Back Matter....Pages 415-421 Based on the August 2001 29th annual meeting of the International Society for Oxygen Transport to Tissue, held in Philadelphia, Pennsylvania, this book surveys the latest advances in oxygen transport to tissue, with material organized in sections on tumor biology and physiology, blood physiology and blood substitutes, nitric oxide biology and physiology, oxygen measurement methods and applications, oxygen in eye and muscle physiology, tissue hypoxia and ischemia, and functional alterations in blood flow and oxygenation. Some specific subjects are molecular imaging by PET, and mechanisms underlying hypoxia development in tumors. Annotation ©2003 Book News, Inc., Portland, OR This volume covers all aspects of oxygen delivery to tissue, including blood flow and its regulation, as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This is a multidisciplinary volume designed to bring together experts and students from a range of research fields.