Oxygen Sensing: Responses and Adaptation to Hypoxia (Lung Biology in Health and Disease)

Content: GENOMICS OF OXYGEN SENSING, Gregg L. SemenzaBiochemistry and Physiological Importance of Heme Proteins as Oxygen Sensors, Marie-Alda Gilles-GonzalezA Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast, Robert O. Poyton, Reinhard P. Dirmeier, Kristin M. O'Brien, and Erick SpearsRegulation of HIF-1 by Oxygen: The Role of Prolyl Hydroxylase and the VHL Tumor Suppressor, Patrick H. Maxwell and Peter J. RatcliffeOxygen- or Redox-Dependent Regulation: The Role of Hydrogen Peroxide in the Regulation of Erythropoietin Gene Expression, Joachim FandreyStructure and Regulation of the Mouse Hypoxia-Inducible Factor-1a Gene, Roland H. WengerHypoxia-Inducible Factor 1: More Than a Hypoxia-Inducible Transcription Factor, Thomas Hellwig?Bnrgel, Daniel Phillip Stiehl, and Wolfgang JelkmannBrain Microvascular and Metabolic Adaptation to Prolonged Mild Hypoxia, Faton H. Agani, Juan Carlos Ch?vez, Paola Pichiule, and Joseph C. LaMannaMolecular Adaptation to Hypoxia, Karen A. Seta, Yong Yuan, Zachary Spicer, Gang Lu, and David E. MillhornRegulation of Tyrosine Hydroxylase Gene Expression by Hypoxia in Neuroendocrine Cells, Maria F. Czyzyk Krzeska, Phillip O. Schnell, Amy L. Bauer, Justin B. Striet, James A. Nash, Anna V. Kuznetsova, and Anna S. HuiGenome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans, Thomas A. Gorr, Pavel Hradecky, Joshua D. Cahn, and H. Franklin BunnOXYGEN SENSING IN THE CAROTID BODY, AND OTHER CELLS, ORGANS, AND ORGANELLES, Sukhamay Lahiri and Nanduri R. PrabhakarFetal Adaptations to Hypoxia, James P. Newman, Mark A. Hanson, and Lucy R. GreenPerinatal Transition of Oxygen Sensing in the Peripheral Chemoreceptors, Jean-Christophe Roux, Julie Peyronnet, and Hugo LagercrantzPostnatal Maturation of the Carotid Chemoreceptor O2 Sensitivity at the Cellular Level, John L. CarrollMaturation of Chemoreceptor O2 and CO2 Sensitivity, Prem KumarFurther Evidence That Oxygen Sensing in the Carotid Body Involves Iron and Heme Proteins, Sukhamay Lahiri, Arijit Roy, Anil Mokashi, Peter A. Daudu, Jinquing Li, Santhosh M. Baby, and Donald G. BuerkO2-Sensitive K+ Channels Controlling Cell Excitability, Chris Peers, Anthony Lewis, Leigh D. Plant, Hugh A. Pearson, and Paul J. KempCarotid Body Thin Slices: New Answers for Old Questions, Jos? L pez-Barneo and Ricardo PardalElectric and Dye Coupling Between Rat Carotid Body Cells and Between These Cells and Carotid Nerve Endings, Carlos Eyzaguirre, Rugang Jiang, and Ver nica AbudaraFrom Oxygen Sensing to Chemosensory Activity: The Mediator Role of Glomus Cells, Patricio ZapataExcitation of Glomus Cells: Interaction Between Voltage-Gated K+ Channels and Cholinergic Receptors, Machiko Shirahata, Tomoko Higashi, Serabi Hirasawa, Shigeki Yamaguchi, Robert S. Fitzgerald, and Boris LandeSome Neurotransmitter Relationships in the Carotid Body' INTRODUCTION......Page 11 FOREWORD......Page 13 PREFACE......Page 15 CONTRIBUTORS......Page 17 CONTENTS......Page 27 Part One Genomics of Oxygen Sensing......Page 40 Biochemistry and Physiological Importance of Heme Proteins as Oxygen Sensors......Page 46 A Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast......Page 62 Regulation of HIF-1 by Oxygen......Page 86 Oxygen- or Redox-Dependent Regulation......Page 106 Structure and Regulation of the Mouse Hypoxia-Inducible Factor-1a Gene......Page 122 Hypoxia-Inducible Factor-1......Page 134 Brain Microvascular and Metabolic Adaptation to Prolonged Mild Hypoxia......Page 148 Molecular Adaptation to Hypoxia......Page 162 Regulation of Tyrosine Hydroxylase Gene Expression by Hypoxia in Neuroendocrine Cells......Page 192 Genome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans......Page 214 Part Two OXYGEN SENSING IN THE CAROTID BODY, AND OTHER CELLS, ORGANS, AND ORGANELLES......Page 240 Fetal Adaptations to Hypoxia......Page 248 Perinatal Transition of Oxygen Sensing in the Peripheral Chemoreceptors......Page 274 Postnatal Maturation of the Carotid Chemoreceptor O2 Sensitivity at the Cellular Level......Page 290 Maturation of Chemoreceptor O2 and CO2 Sensitivity......Page 312 Further Evidence That Oxygen Sensing in the Carotid Body Involves Iron and Heme Proteins......Page 328 O2-Sensitive K+ Channels Controlling Cell Excitability......Page 338 Carotid Body Thin Slices......Page 354 Electric and Dye Coupling Between Rat Carotid Body Cells and Between These Cells and Carotid Nerve Endings......Page 370 From Oxygen Sensing to Chemosensory Activity......Page 392 Excitation of Glomus Cells......Page 404 Some Neurotransmitter Relationships in the Carotid Body’s Response to Hypoxia......Page 420 Effects of Nitric Oxide on Carotid Body Oxygen Consumption at Low PO2......Page 434 Nitric Oxide and Carotid Body Chemoreception......Page 448 Multiple Roles of Neurotransmitters in the Carotid Body......Page 460 Mechanisms of Morphological and Functional Plasticity in the Chronically Hypoxic Carotid Body......Page 478 Neurochemical Processes Involved in Acclimatization to Long-Term Hypoxia......Page 506 Biology of Reactive Oxygen Species......Page 528 Optical Analysis of the Oxygen-Sensing Signal Pathway......Page 546 Mitochondria as Vascular Oxygen Sensors......Page 562 Roles for NAD(P)H Oxidases as Vascular Oxygen Sensors and Their In.uence on Oxidant-Regulated Signaling Mechanisms......Page 592 Oxygen Sensing in Pulmonary Neuroepithelial Bodies and Related Tumor Cell Model......Page 606 Oxygen Sensing by Neonatal Adrenal Chromaf.n Cells......Page 642 O2 Sensing in Neurons......Page 658 Oxygen Sensitivity of Central Cardiorespiratory Regions......Page 672 Oxygen Sensing by the Brainstem in Respiratory Control......Page 690 Petrosal Ganglion Responses In Vitro......Page 710 Comparative Aspects of O2 Chemoreception......Page 724 AUTHOR INDEX......Page 748 SUBJECT INDEX......Page 804 "Oxygen Sensing examines O[subscript 2] sensing systems in bacteria and Archaea ... demonstrates interrelationships among cell proliferation, energy metabolism, oxygen homeostasis, redox states, signal transduction, and gene expression in humans and other organisms ... details the role of excitatory and inhibitory neurotransmitters in sensory signaling ... describes the effect of hypoxia on carotid body structure and function ... and considers the effect of alterations in oxygen homeostasis on the pathophysiology of cardiac ischemia, cancer, stroke, and chronic lung disease."--BOOK JACKET. Reviewing research on the molecular basis of oxygen homeostasis, this text describes the changes in intracellular signalling and gene expression that lead to physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing systems in bacteria and archaea and demonstrates interrelationships among cell pr Intracellular O2 concentrations in humans and other mammals are maintained within a relatively narrow range, with partial pressures of O2 varying between a high of approximately 110 mmHg (16% O2 at sea level) in the pulmonary alveoli to a low of less than 20 mmHg (3% O2) in some areas of the heart, kidney, and brain.