Oxidative stress, inflammation, and angiogenesis in the metabolic syndrome

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders. 1. The Metabolic Syndrome / Ana Azevedo, Ana C. Santos, Laura Ribeiro, Isabel Azevedo -- 2. Oxidative Stress : From The 1980s To Recent Update / Joao Laranjinha -- 3. Oxidative Stress In The Metabolic Syndrome / Conceî̇o Calhau, Alejandro Santos -- 4. Chronic Inflammation In The Metabolic Syndrome : Emphasis On Adipose Tissue / Ros̀rio Monteiro -- 5. Angiogenesis In The Metabolic Syndrome / Raquel Soares -- 6. Role Of Endothelial Progenitor Cells In The Metabolic Syndrome / Carla Costa -- 7. Vascular Glucose Transport And The Metabolic Syndrome / Fatima Martel, Elisa Keating -- 8. Natural Polyphenols As Anti-oxidant, Anti-inflammatory And Anti-angiogenic Agents In The Metabolic Syndrome / Rita Negr̂o, Ana Faria -- 9. Metabolic Syndrome: Practical Implications Of A Concept / Cassiano Abreu-lima. Edited By Raquel Soares And Carla Costa. Includes Bibliographical References And Index. Front Matter....Pages I-X The Metabolic Syndrome....Pages 1-19 Oxidative Stress: From the 1980’s to Recent Update....Pages 21-32 Oxidative Stress in the Metabolic Syndrome....Pages 33-63 Chronic Inflammation in the Metabolic Syndrome: Emphasis on Adipose Tissue....Pages 65-84 Angiogenesis in the Metabolic Syndrome....Pages 85-99 Role of Endothelial Progenitor Cells in the Metabolic Syndrome....Pages 101-121 Vascular Glucose Transport and the Metabolic Syndrome....Pages 123-146 Natural Polyphenols as Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Agents in the Metabolic Syndrome....Pages 147-180 Metabolic Syndrome: Practical Implications of a Concept....Pages 181-186 Back Matter....Pages 187-209 Offers a critical review and discussion of the knowledge gathered on Metabolic Syndrome (MS) and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. This volume focuses on various discoveries and progress toward possible therapeutic strategies This book reviews and discusses knowledge gathered on Metabolic Syndrome and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. It focuses on recent discoveries and progress toward possible therapeutic strategies.