Oxidation : the cornerstone of carcinogenesis : oxidation and tobacco smoke carcinogenesis : a relationship between cause and effect

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research. Front Matter....Pages I-XXII Oxygen and Nitrogen Free Radicals....Pages 1-30 Oxidative Stress....Pages 31-48 Oxidative Damage of Genome DNA: Repair Mechanisms....Pages 49-62 Mitochondria: Structure, Function and Relationship with Carcinogenesis....Pages 63-96 Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants....Pages 97-116 Cell Protection Mechanisms from Oxidation....Pages 117-126 Role of DNA Adducts in Carcinogenesis....Pages 127-135 Transmolecular Reactions of Genetic Toxicity: Alkylation and Methylation of DNA....Pages 137-144 Toxicity and Carcinogenicity of Hydrocarbons....Pages 145-152 Toxicity and Carcinogenicity of the Aromatic Hydrocarbons....Pages 153-160 Toxicity and Carcinogenicity of Aldehydes....Pages 161-173 Toxicity and Carcinogenicity of the Nitriles....Pages 175-179 Toxicity and Carcinogenicity of the Eterocyclic Organic Compounds....Pages 181-182 Toxicity and Carcinogenicity of Metals....Pages 183-210 Oxidative Profile of Cigarette Smoke and Lung Cancer....Pages 211-218 Smoking and Lung Cancer....Pages 219-239 Back Matter....Pages 241-258 "In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research."--Jacket