Oxford Textbook of Axial Spondyloarthritis (Oxford Textbooks in Rheumatology)

Axial spondyloarthritis is a relatively new term, now becoming widely accepted in clinical practice, referring to inflammatory disease predominantly of the spine where the main symptom is back pain. The most common subset of AxSpA is ankylosing spondylitis. This is a rapidly evolving field with new diagnostic criteria and treatments, which are likely to evolve further. This book covers the significant recent advances in the epidemiology, genetics, pathogenesis, classification, and treatment of this disabling disease, from a truly global perspective. Axial Spondyloarthritis is a timely addition to the Oxford Textbooks in Rheumatology series, providing a comprehensive reference to this rapidly evolving field. The conceptual framework of the disease has now evolved beyond ankylosing spondylitis to encompass a broader concept of axial inflammation. Earlier recognition has opened the door to earlier intervention, and the understanding of the biologic basis of axial SpA has seen significant advances in recent years. The first textbook to cover axial spondyloarthritis in this level of detail from a global perspective, this volume offers a practical and complete resource compiled by a multidisciplinary and multinational team of experts. Beginning with a historical perspective on the disease, the textbook provides a comprehensive background in the epidemiology, diagnosis, and classification of axial spondyloarthritis. Immune mechanisms and genetics are covered, along with imaging and a detailed section on the range of treatments options currently available. A section on extra-articular manifestations provides a comprehensive knowledge base for the clinician treating patients with spondyloarthritis, and chapters on the economics of the disease, physical functioning, and patient registries complete the broad coverage of the topic. Practical, easy to use, yet detailed with respect to pathophysiology, diagnostics, and management, this textbook provides a comprehensive reference for rheumatologists, general practitioners, internists, and paediatricians managing patients with axial spondyloarthritis. Content: Cover Series Oxford Textbook of Axial Spondyloarthritis Copyright Dedication Contents List of contributors Symbols and abbreviations 1 Spondyloarthritis in antiquity and in history 2 Epidemiology of axial spondyloarthritis 3 Diagnosis and classification of axial spondyloarthritis 4 Diagnosis, classification, and management of peripheral spondyloarthritis 5 Genetics of spondyloarthritis 6 Immune mechanisms: HLA-​B27 7 Immune mechanisms: innate immunity 8 Immune mechanisms: adaptive immunity 9 Infection and spondyloarthritis 10 Pathology: bone 11 Clinical features 12 Clinical outcomes13 Imaging: sacroiliac joints 14 Imaging: spine 15 Juvenile-​onset spondyloarthritis 16 Extra-​articular manifestations: uveitis 17 Extra-​articular manifestations: inflammatory bowel disease 18 Extra-​articular manifestations: psoriasis 19 Non-​pharmacological management in axial spondyloarthritis 20 Treatment: NSAIDs 21 Treatment: DMARDs 22 Treatment: biologics 23 Treatment: spinal surgery 24 Patient registries 25 Cost-​of-​illness and economic evaluations in axial spondyloarthritis 26 Physical functioning and work ability 27 Patient support and advocacy 28 Axial spondyloarthritis in Asia29 Axial spondyloarthritis in Latin America 30 Axial spondyloarthritis in India Index Part of the Oxford Textbooks in Rheumatology series, this volume will cover the significant recent advances in the genetics, classification, and treatment of Axial Spondyloarthritis, making this text a timely addition to the medical literature. Abstract: Part of the Oxford Textbooks in Rheumatology series, this volume will cover the significant recent advances in the genetics, classification, and treatment of Axial Spondyloarthritis, making this text a timely addition to the medical literature