Oxalate Metabolism in Relation to Urinary Stone (The Bloomsbury Series in Clinical Science)

"Oxalate Metabolism in Relation to Urinary Stone" is the third monograph to appear in the "Bloomsbury Series". Edited by Alan Rose, the book describes the current clinical and biochemical features of oxalate metabolism. Its content and direction fulfil the goals of the Series emphasising the strong links between basic science and clinical medicine. London Jack Tinker 30 March 1988 Preface The first oxalate workshop was held in London in 1979 and the proceedings published privately by the Wellcome Foundation. At that time the importance of urinary oxalate as a risk factor more important for calcium oxalate stone formation than urinary calcium had been recognized. Nevertheless measurements of urinary oxalate still left a lot to be desired and in particular the non-enzymatic conversion of ascorbate to oxalate had not been rediscovered so that many measurements must have been wrong. Plasma oxalate was still difficult or impossible to measure by any reasonable, accessible methods and consequently there was still much argument and speculation about the handling of oxalate by the kidneys. A lot of work has been performed in the last eight years on oxalate metabolism and it therefore seemed to the organisers to be a good time to hold a second oxalate workshop. Front Matter....Pages i-xvi Introduction....Pages 1-6 Assay of Oxalate and Glycollate in Urine....Pages 7-26 Experiences with an External Quality Assessment Scheme for Urinary Oxalate....Pages 27-44 Assaying of Oxalate in Plasma....Pages 45-64 Primary Hyperoxaluria....Pages 65-81 Primary Hyperoxaluria in Children....Pages 83-101 Enteric and Other Secondary Hyperoxalurias....Pages 103-119 Mild Metabolic Hyperoxaluria. A New Syndrome....Pages 121-130 Oxalate Crystalluria....Pages 131-166 Renal Failure and Transplantation in Primary Hyperoxaluria....Pages 167-176 Vitamin B6 Metabolism in Relation to Metabolic Hyperoxaluria....Pages 177-192 Back Matter....Pages 193-197 This volume presents an authoritative and up-to-date review of the analytical and clinical problems relating to oxalate, which is known to be an extremely important factor in the formation of calcium oxalate urinary stone. Information is provided on how to analyse oxalate and glycollate in blood and urine, upon the precision with which laboratories analyse oxalate in urine and upon the investigations and treatment of the various hypoxaluries including medical therapy and the role of kidney and liver transplantation. The relevance of oxalate crystalluria and vitamin B6 metabolism is also considered