Overweight and the Metabolic Syndrome:: From Bench to Bedside (Endocrine Updates, 26)

This volume examines the problem of the overweight individual and the metabolic syndrome from the laboratory bench to the bedside. Clearly, translating the findings we make in the laboratory to the betterment of humankind is an important mission. Areas where basic science is making important contributions to the problems associated with metabolic syndrome are illustrated in the chapters on Neuroendocrine Control of Food Intake, Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity, and Ectopic Fat and Metabolic Syndrome. For each of these, the fast-moving basic science area is opening new vistas for translation to the bedside and clinic. The larger segment of the book deals with the clinical context for the metabolic syndrome, central adiposity and overweight. The methods for measurement are well described and the application of these methods to evaluating patients and determining the prevalence in society is indicated. Genetic components of overweight and the metabolic syndrome are reviewed. The key role of visceral fat is emphasized by giving it a chapter of its own written by one of the foremost investigators of this problem. The importance of overweight and the metabolic syndrome in children is recognized in a separate chapter. There are a number of chapters focusing on treatment including behavioral therapy, exercise, diet, medications and surgery. In summary, this book is the alpha and omega of the overweight and metabolic syndrome problem. Series editor comments: Drs. Bray and Ryan have assembled a superb panel of authors who bring their expertise to this very timely book for medical practice. The epidemic of obesity is addressed in authoritative and cutting edge chapters ranging from the fundamental genetics and physiology of appetite control through the latest pharmacologic applications and surgical interventions. This is a "must have" volume for those treating patients with appetite disorders, obesity and diabetes, as well as those studying the intrinsic cellular and whole body pathogenesis of this modern population disorder. Shlomo Melmed, M.D. Series Editor Endocrine Updates Ch. 1. Neuroendocrine Control Of Food Intake / Andrew A. Butler, James L. Trevaskis And Christopher D. Morrison -- Ch. 2. Body Composition Assessment Of Obesity / Wm. Cameron Chumlea -- Ch. 3. Prevalence Of Obesity And The Metabolic Syndrome / Ali H. Mokdad And Earl S. Ford -- Ch. 4. The Genetic Contribution To Obesity / Raul A. Bastarrachea, Jack W. Kent, Jr., Jeff T. Williams, Guowen Cai, Shelley A. Cole And Anthony G. Comuzzie -- Ch. 5. Etiology Of Obesity : The Problem Of Maintaining Energy Balance / Barry E. Levin And Deborah J. Clegg -- Ch. 6. Current Views Of The Fat Cell As An Endocrine Cell : Lipotoxicity / Tamara Tchkonia, Barbara E. Corkey And James L. Kirkland -- Ch. 7. Ectopic Fat And The Metabolic Syndrome / Frederico G. S. Toledo And David E. Kelley -- Ch. 8. Abdominal Obesity And The Metabolic Syndrome / Jean-pierre Despres, Isabelle Lemiux And Natalie Almeras -- Ch. 9. The Problems Of Childhood Obesity And The Metabolic Syndrome / Sonia Caprio And Ram Weiss -- Ch. 10. Evaluation Of The Overweight And Obese Patient / George A. Bray And Donna H. Ryan -- Ch. 11. Dietary Approaches To Obesity And The Metabolic Syndrome / Gary D. Foster And Angela P. Makris -- Ch. 12. Exercise As An Approach To Obesity And The Metabolic Syndrome / John M. Jakicic And Amy D. Otto -- Ch. 13. Behavioral Strategies For Controlling Obesity / Donald A. Williamson, Corby K. Martin And Tiffany M. Stewart -- Ch. 14. Obesity Prevention / Shiriki K. Kumanyika And Stephen R. Daniels -- Ch. 15. Orlistat And Sibutramine In The Management Of Obesity / Holly Wyatt -- Ch. 16. A Status Of Drugs On The Horizon For Obesity And The Metabolic Syndrome -- A Comprehensive Review 2005 / Frank Greenway And George Bray -- Ch. 17. Surgical Treatment Of The Overweight Patient / George A. Bray. Edited By George A. Bray, Donna H. Ryan. Includes Bibliographical References And Index. This volume examines the problem of the overweight individual and the metabolic syndrome from the laboratory bench to the bedside. Clearly, translating the findings we make in the laboratory to the betterment of humankind is an important mission. Areas where basic science is making important contributions to the problems associated with the metabolic syndrome are illustrated in the chapters on Neuroendocrine Control of Food Intake, Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity, and Ectopic Fat and Metabolic Syndrome. For each of these, the fast-moving basic science area is opening new vistas for translation to the bedside and clinic.The larger segment of the book deals with the clinical context for the metabolic syndrome, central adiposity and overweight. The methods for measurement are well described and the application of these methods to evaluating patients and determining the prevalence in society is indicated. Genetic components of overweight and the metabolic syndrome are reviewed. The key role of visceral fat is emphasized by giving it a chapter of its own written by one of the foremost investigators of this problem. The importance of overweight and the metabolic syndrome in children is recognized in a separate chapter. There are a number of chapters focusing on treatment including behavioral therapy, exercise, diet, medications and surgery. In summary, this book is the alpha and omega of the overweight and metabolic syndrome problem. Front Matter....Pages i-xxi Neuroendocrine Control of Food Intake....Pages 1-21 Body Composition Assessment of Obesity....Pages 23-35 Prevalence of Obesity and the Metabolic Syndrome....Pages 37-53 The Genetic Contribution to Obesity....Pages 55-81 Etiology of Obesity: The Problem of Maintaining Energy Balance....Pages 83-103 Current Views of the Fat Cell as an Endocrine Cell: Lipotoxicity....Pages 105-123 Ectopic Fat and the Metabolic Syndrome....Pages 125-136 Abdominal Obesity and the Metabolic Syndrome....Pages 137-152 The Problems of Childhood Obesity and the Metabolic Syndrome....Pages 153-168 Evaluation of the Overweight and Obese Patient....Pages 169-186 Dietary Approaches to Obesity and the Metabolic Syndrome....Pages 187-210 Exercise as an Approach to Obesity and the Metabolic Syndrome....Pages 211-218 Behavioral Strategies for Controlling Obesity....Pages 219-232 Obesity Prevention....Pages 233-253 Orlistat and Sibutramine in the Management of Obesity....Pages 255-279 A Status of Drugs on the Horizon for Obesity and the Metabolic Syndrome—a Comprehensive Review 2005....Pages 281-306 Surgical Treatment of the Overweight Patient....Pages 307-327 Back Matter....Pages 329-335 Overweight and the Metabolic Syndrome will provide an overview of topics related to obesity, including associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The body composition that underlies obesity and the metabolic syndrome is key to understanding the problem. The mechanisms by which energy balance is maintained is key to how the problem goes wrong. The metabolic syndrome is in part a consequence of central fat storage, but includes more issues such as insulin resistance, low levels of inflammation, and endothelial dysfunction. This volume will cover evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic. This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.