Ovarian Follicular and Corpus Luteum Function (Advances in Experimental Medicine and Biology, 112)

Front Matter....Pages i-xv Front Matter....Pages 1-1 Introductory Remarks: Ruminations on Ovarian Function....Pages 3-8 Front Matter....Pages 9-9 Follicular Growth in the Rat: A Reevaluation of the Roles of FSH and LH....Pages 11-26 LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian Follicles....Pages 27-44 Gonadal LH Receptors: Resolution from Adenylate Cyclase and Transfer to Heterologous Cells....Pages 45-51 Prolactin Control of Receptor for Estradiol in Corpora Lutea of Pregnant Rats....Pages 53-58 Discussion — Chairperson....Pages 59-68 Lateral Mobility and Internalization of Hormone Receptors to Human Chorionic Gonadotropin in Cultured Rat Granulosa Cells....Pages 69-75 FSH Stimulation of Mucopolysaccharide Synthesis in Rat and Porcine Ovary....Pages 77-82 Immunologic Impairment of Δ 5 -3B Hydroxysteroid Dehydrogenase and Its Effect on Ovarian Function: The Use of a Purified Enzyme....Pages 83-88 Receptors for Gonadotrophins in the Ovine Follicle During Growth and Atresia....Pages 89-94 Effect of Oestradiol-17β and Gonadotrophins on Prostaglandin production by Pre-Ovulatory Pig Follicles Superfused In Vitro ....Pages 95-103 LH-Stimulated cAMP Formation in Rat Granulosa Cells During Follicular Maturation — A Non-Refractory Response....Pages 105-112 Effect of the Administration of an Ovulatory Dose of HCG on the Subcellular Distribution of Follicular Protein Kinase....Pages 113-121 Structural Analysis of Granulosa Cells from Human Ovaries in Correlation with Function....Pages 123-128 Regulation of LH(hCG)-Receptor and Adenylate Cyclase in Luteinizing Granulosa Cells....Pages 129-135 Changes in Responsiveness of Porcine Granulosa Cells to Prostaglandins and Luteinizing Hormone in Terms of Cyclic-AMP Accumulation During Follicular Maturation....Pages 137-143 Some Morphological and Functional Characteristics of Cells of the Porcine Theca Interna in Tissue Culture....Pages 145-148 The Control of Ovulation in the Cow by Prostaglandin Inhibitor....Pages 149-152 Front Matter....Pages 153-153 Steroidal Modulation of Steroid Secretion in vitro : An Experimental Approach to Intra-Follicular Regulatory Mechanisms....Pages 155-168 On the Mechanism of Prolactin Stimulation of Steroidogenesis....Pages 169-178 Front Matter....Pages 153-153 Steroid Secretion by Perifused Ovarian Follicles of Immature, Pmsg-Treated Immature, and Mature Rabbits....Pages 179-185 Effects of Follicular Development on the Ability of Cultured Porcine Granulosa Cells to Convert Androgens to Estrogens....Pages 187-195 Testosterone Synthesis by Chicken Follicular Cells....Pages 197-202 Modulation of Thecal Progesterone Secretion by Estradiol-17β....Pages 203-208 General Discussion — Steroidogenesis....Pages 209-218 Steroid Secretion by Ovarian Follicles of Rabbits in Different Reproductive States....Pages 219-224 Hormone Requirements for Long-Term Maintenance of Rat Granulosa Cell Cultures....Pages 225-233 Long Term Perifusion of Rabbit Ovarian Follicles....Pages 235-239 Estrogen Inhibits Porcine Thecal Androgen Production in vitro ....Pages 241-243 Antral Follicular and Interstitial Contributions to Progesterone Secretion in the Proestrous Hamster....Pages 245-247 Front Matter....Pages 249-249 Meiotic Maturation of Mouse Oocytes in Vitro ....Pages 251-268 Mammalian Oocyte Maturation: Model Systems and Their Physiological Relevance....Pages 269-282 Action of Porcine Follicular Fluid Oocyte Maturation Inhibitor in Vitro: Possible Role of the Cumulus Cells....Pages 283-291 Relationship Between Steroidogenesis and Oocyte Maturation in Rat Graafian Follicles Cultured in vitro ....Pages 293-300 Discussion....Pages 301-306 The Somatic-Germ Cell Complex: Interactions and Transformations in Relation to Oocyte Maturation....Pages 307-314 Rapid Oocyte Death Prior to and at Puberty in Neonatally Thymectomized Mice....Pages 315-320 Maturation and Atresia of Human Oocytes in Vivo ....Pages 321-324 Front Matter....Pages 325-325 Follicular Non-Steroidal Regulators....Pages 327-345 The Influence of Follicular Fluid on Progesterone Secretion by Porcine Granulosa Cells in Vitro....Pages 347-359 Front Matter....Pages 325-325 Inhibition of in Vivo and in Vitro FSH Secretion by Steroid-Free Hamster Ovarian Extracts....Pages 361-373 The Differential Ability of Porcine Follicular Fluid to Suppress Serum FSH in Female Rats from 6 Days of Age to Adulthood....Pages 375-381 Evidence for the Presence of a Low Molecular Weight Follitropin Binding Inhibitor in Bovine Follicular Fluid....Pages 383-388 Chairperson’s Remarks....Pages 389-400 Inhibition by Follicular Fluid of Luteinizing Hormone-Sensitive Adenylate Cyclase in Ovarian Plasma Membranes....Pages 401-406 Inhibitory Effect of Charcoal-Treated Porcine Follicular Fluid upon Serum FSH Levels and Follicular Development in the Rhesus Monkey....Pages 407-415 Follicular Fluid Inhibition of Ovulation....Pages 417-421 Modulation of Pituitary Responsiveness to LHRH by Porcine Follicular Fluid: Time and dose- Dependent Effects....Pages 423-428 Isolation and Preliminary Characterization of Inhibin-f....Pages 429-435 Evidence That the Pituitary Gland is the Site of Inhibitory Action of Porcine Follicular Fluid upon FSH Secretion in the Rat....Pages 437-443 Front Matter....Pages 445-445 Estrogen Action in the Corpus Luteum....Pages 447-463 Follicular Determinants of Corpus Luteum Function in the Human Ovary....Pages 465-481 LH Receptors in the Ovine Corpus Luteum During the Estrous Cycle and Early Pregnancy....Pages 483-488 Gonadotropin Action in Isolated Ovarian Luteal Cells: The Intermediate Role of Adenosine 3′, 5′ Cyclic Monophosphate in Hormonal Stimulation of Progesterone Synthesis....Pages 489-495 Chairperson’s Remarks....Pages 497-503 Changes in Ovarian Mitochondria: Early Indicators of Follicular Luteinization....Pages 505-510 Prostaglandin F 2 α and Progesterone Synthesis in Vitro by Bovine Corpora Lutea of Early Pregnancy....Pages 511-517 Luteal Phase Deficiencies in Peripubertal Rhesus Monkeys: Mechanistic Considerations....Pages 519-525 Cellular Mechanisms Involved in Luteolysis....Pages 527-533 Role of Pituitary LH and Placenta in Luteal Progesterone Production and Maintenance of Pregnancy in the Rat....Pages 535-540 Front Matter....Pages 445-445 Relationships between Cholesterol Supply and Luteal Mitochondrial Steroid Synthesis....Pages 541-543 A Comparison of the LH Control of Progesterone Synthesis in Small and Large Cells from Pregnant Cow Corpus Luteum....Pages 545-548 Cytochalasin B Inhibition of Luteinizing Hormone Action on Bovine Luteal Cells....Pages 549-554 Front Matter....Pages 555-555 Mechanisms of PGF 2α Action in Functional Luteolysis....Pages 557-575 Prostaglandin F 2α and Its 13-Dehydro Analogs: Comparative Luteolytic Effects in Vivo ....Pages 577-601 Effects of Cholera Toxin, LH and PGF 2α on Steroidogenesis in Luteal Cells....Pages 603-611 Effects of Prostaglandin F 2 α, Estradiol and Luteinizing Hormone in Dispersed Cell Preparations of Bovine Corpora Lutea....Pages 613-620 General Discussion of Luteolysis....Pages 621-625 In Vitro Release of Progesterone and Prostaglandins F and E by Porcine Luteal and Endometrial Tissue during Induced Luteolysis....Pages 627-632 Demonstration of Luteal Cell Membrane Receptors for Prostaglandin F 2α by Ultrastructural and Binding Analysis....Pages 633-638 Prostaglandin F 2α and Progesterone Release in Vitro by Ovine Luteal Tissue during Induced Luteolysis....Pages 639-644 Front Matter....Pages 645-645 Luteal Desensitization: Hormonal Regulation of LH Receptors, Adenylate Cyclase and Steroidogenic Responses in the Luteal Cell....Pages 647-662 Interactions among Estrogen, Prolactin and Luteinizing Hormone at the Level of Adenylyl Cyclase in the Corpus Luteum: Findings and Physiological Correlates....Pages 663-677 Desensitization and Recovery of PGE 2 -Responsive Ovarian Adenylate Cyclase Modulated by Agents Affecting Cytoskeletal Function....Pages 679-686 Inhibitory Effects of Treatment with LHRH or Its Agonists on Ovarian Receptor Levels and Function....Pages 687-693 Discussion....Pages 695-701 Mechanism and Significance of Luteal Desensitization: Chairman’s Concluding Remarks....Pages 703-710 Lutropin Induced Desensitization of Rat Ovarian Adenylate Cyclase: A GTP-Dependent Process....Pages 711-715 hCG-Induced Loss of LH-hCG Receptor and Desensitization of Adenylate Cyclase....Pages 717-722 Evidence of a Greater Activity of LH/HCH Binding Inhibitor Present in Aqueous Extracts from Old Compared to Young Porcine Corpus Luteum....Pages 723-728 Front Matter....Pages 645-645 Suppression of Ovarian Function by LHRH and Its Analogues in Pregnant Rats....Pages 729-734 Front Matter....Pages 735-735 Clinical Applications in the Area of Contraceptive Development....Pages 737-742 Serum Immunoreactive Relaxin Concentrations in Human Pregnancy, Labor and the Puerperium....Pages 743-748 Effect of Removal of Carbohydrate Residues upon the Half Life and in Vivo Biological Activity of Human Chorionic Gondadotropin....Pages 749-756 A Procedure for Evaluating Luteolytic Agents in Primates....Pages 757-766 Summing Up....Pages 767-789 Back Matter....Pages 791-808