Ovarian Cancer: The "Gynaecological Challenge" from Diagnostic Work-Up to Cytoreduction and Chemotherapy. Volume 1

Ovarian cancer is one of the deadliest gynaecological cancers. In most cases, it is detected as an advanced tumor, since early diagnosis is challenging for most forms of the disease. Surgery and platinum-based compounds have been the mainstay of therapy for many years. The prognosis for ovarian cancer depends on the type of surgery and on the response to chemotherapy. Other regimens have little effect if the disease does not respond to platinum. However, several new therapies are emerging including bevacizumab and PARP-inhibitors, among others. This book provides a detailed body of information important to an understanding of the clinical aspects and management of such a challenging disease. The authors strive to provide the physician with insights and illustrations as well as useful tips and tricks for the everyday clinical practice. Several world-known experts in the field participated in this fruitful effort offering their knowledge and everyday experience, as well as valuable and original photos from their personal archives as well as the most recent and up-to-date guidelines in the field. In this book, we evaluate all the challenging pathways from the moment of diagnosis to the surgical and medical therapies. The pathogenesis, the variation of the morphological types and the problems in differential diagnosis are also discussed. Moreover, we provide an overview of recent attempts to improve the diagnosis and prognosis of ovarian cancer as well as a discussion of fertility sparing alternatives and minimal invasive (laparoscopic and robotic) approaches. All the new diagnostic and therapeutic strategies that lay out the foundation for these improvements are presented. Areas of future research are also discussed, supported by a wealth of up-to-date referenced material. The book is written at a level appropriate for both medical students, physicians as well as gynaecological oncologists, pathologists, and medical oncologists. Contents Preface 1 Ovarian Cancer Pathology and Surgery, Historical Pearls from the Pioneering Greeks and the General Term Gynecologic Cancer to Modern Histopathology and Ovarian Malignancy • G. Tsoucalas, Christos Iavazzo and M. Karamanou 2 Ovarian Cancer Screening • Aleksandra Gentry-Maharaj and Aarti Sharma 3 The Role of Ultrasounds in the Diagnosis and Management of Adnexal Tumors • Natalie Nunes and Davor Jurkovic 4 Preoperative Biomarkers to Predict Resectability of Patients with Ovarian Cancer • Valerio Mais, Michele Peiretti, Daniela Fanni, Maria Luisa Fais, Giulia Carboni, Giuseppe Deo, Giuseppina Fais and Stefano Angioni 5 Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) Findings in Ovarian Cancer • Skouras Ioannis, Kokkali Kalliopi and Fotiou Alexandros 6 The Role of 18FDG PET/CT Scans in Ovarian Cancer Patients • Lydia Iordanidou 7 The Pathogenesis of Ovarian Cancer • Victoria Psomiadou 8 Inherited Ovarian Cancer-Linked Syndromes and Management • Malcolm Scott, Adam Rosenthal and Terri McVeigh 9 Pathology of Epithelial Ovarian Tumors • Helen J. Trihia 10 Pathology of Non-epithelial Ovarian Tumors • Christos Iavazzo, Alexandros Fotiou, John Spiliotis and Agathi Kondi-Pafiti 11 The Role of Immunohistochemistry in Ovarian Tumors • Christos Valavanis, Efthymia Souka and Gabriela-Monica Stanc 12 Molecular Pathology of Epithelial Ovarian Tumors • Christos Valavanis, Efthymia Souka and Gabriela-Monica Stanc 13 An Approach to Borderline Ovarian Tumors • Maria Luisa Fais, Giorgio Candotti, Giulia Carboni, Giuseppe Deo, Giuseppina Fais, Valerio Mais, Stefano Angioniand Michele Peiretti 14 Prophylactic Salpingo-Oophorectomy in High-Risk Patients • Paul I. Stanciu and Sabina Mistry 15 The Management of Early-Stage Epithelial Ovarian Cancer • Virginia García Pineda, Violeta Romero and Ignacio Zapardiel 16 Fertility Sparing in Ovarian Cancer Patients • Myriam Gracia, Ana Peralbo and Ignacio Zapardiel 17 The Local-Regional Control of Ovarian Cancer • Paul H. Sugarbaker 18 Surgical Management of Advanced Epithelial Ovarian Cancer • Fuat Demirkiran and Ipek Betül Özçivit 19 Primary Versus Interval Debulking Surgery in Ovarian Cancer Patients • Yusuf Yildirim and Volkan Karatasli 20 Lymphadenectomy in Ovarian Cancer Surgery • Fuat Demirkiran and Elif Akşahin 21 Serous Papillary Primary Peritoneal Carcinoma • Marcello Deraco, Navinakathiresu Muthukumarasamy, Dario Baratti, Marcello Guaglio and Shigeki Kusamura 22 Ovarian Carcinosarcoma • Ilker Kahramanoglu and Olcay Ilhan 23 Krukenberg Tumors • Federico Coccolini, Riccardo Guelfi, Enrico Cicuttin, Camilla Cremonini, Dario Tartaglia, Marta Carretto, Tommaso Simoncini and Massimo Chiarugi 24 Pseudomyxoma Peritonei • John Spiliotis, Alexandros Fotiou and Christos Iavazzo 25 Ovarian Malignancies during Pregnancy • Miriam Turiel Miranda, Ignacio Cristobal, Elena Martin-Boado and Ignacio Zapardiel Index Editors’ Contact Information