Osteoporosis in older persons : pathophysiology and therapeutic approach

Osteoporosis in Older Persons - Pathophysiology and Therapeutic Approach has the most up-to-date information about the pathophysiology and new therapeutic alternatives. Until recently most effort concerning osteoporosis research was directed mainly at the mechanisms of a type of osteoporosis known as post-menopausal osteoporosis. It was only just recently that a new syndrome, osteoporosis in older persons, was recognized as a new entity with its own pathophysiology and potential treatments. Highlights of this book include:- - Many illustrations showing the basic biological pathways involved in bone aging, as well as the potential links between aging and the changes in bone biology - Figures showing the potential therapeutic targets in bone to prevent and treat osteoporosis, complemented by a complete review on the current treatments - Descriptions of the epidemiology of osteoporotic fractures and their impact on health care costs - Coverage of fractures and their relationship with falls, including new invasive and non-invasive therapeutic approach for osteoporotic fractures - A complete review of future treatments is included explaining their biological basis as well as their potential indications Written by leading clinicians and practitioners in the field this book will be of use to those involved with aging bone research, geriatricians, gerontologists, and bone biologists, as well as offering medical trainees an understanding of the mechanisms of osteoporosis in the older person, with a practical approach to diagnosis and treatment in mind The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls which make it useful not only to biologists but also to clinicians and epidemiologists. The chapters are complemented with color figures showing the basics of bone biology, bone phenotypes and falls prevention interventions and also include tables and flowc. Read more... Abstract: The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls which make it useful not only to biologists but also to clinicians and epidemiologists. The chapters are complemented with color figures showing the basics of bone biology, bone phenotypes and falls prevention interventions and also include tables and flowc Biology of bone / Paul C. Schiller, Gianluca D'Ippolito and Guy A. Howard Aging and bone / Jeffrey M. Gimble ... [et al.] Calciotropic hormones / E. Paul Cherniack and Bruce R. Troen Sex steroids and aging bone / Jane A. Cauley Animal models for senile osteoporosis / Ken Watanabe Senile osteoporosis as a geriatric syndrome / Rujuta H. Patel and Kenneth W. Lyles Genetics of osteoporosis in older age / David Karasik and Douglas P. Kiel Fracture epidemiology among individuals 75+ / Heike A. Bischoff-Ferrari Falls as a geriatric syndrome : how to prevent them? how to treat them? / Manuel Montero-Odasso Non-pharmacological treatments for falls and fractures / Stephen R. Lord, Jacqueline C.T. Close and Catherine Sherrington Medical treatment of age-related osteoporosis: present and future / Steven Boonen Treatment of osteoporosis in long-term care / Gustavo Duque and Louise Mallet Fracture care in the elderly / Christopher M. Bono and Timothy Bhattacharyya. Publisher abstract: Counter The book summarizes recent advances in the elucidation of the mechanisms involved in senile osteoporosis as well as its potential treatment, bringing an integrated approach from the bench to the clinical practice. A unique aspect of this book is its emphasis on the application of translational research in the field of osteoporosis and falls which make it useful not only to biologists but also to clinicians and epidemiologists. The chapters are complemented with color figures showing the basics of bone biology, bone phenotypes and falls prevention interventions and also include tables and flowcharts. Written by investigators (clinicians and basic scientists) in the field of aging bone research, this is a reference guide to geriatricians, gerontologists, endocrinologists, rheumatologists and bone biologists, medical trainees as well as other health professionals (pharmacists, physiotherapists, etc) Content: Biology of bone -- Aging and bone -- Hormones and bone -- Animal models for senile osteoporosis -- Senile osteoporosis: how to recognize a geriatric syndrome?- Epidemiology of osteoporosis -- Falls as a geriatric syndrome, how to prevent it? how to treat it?- Treatment of senile osteoporosis: present and future -- Non pharmacological treatment and prevention of falls and fractures.