Orthopaedic Basic Science: Fifth Edition: Print + Ebook: Foundations of Clinical Practice 5 (AAOS - American Academy of Orthopaedic Surgeons)

Selected as a Doody's Core Title for 2022! Build your Foundation of Basic Science – from Research to Clinical Application and Advancement This fifth edition is your concise and clinically relevant resource for the scientific basis of orthopaedic surgery in support of the diagnosis and treatment of musculoskeletal diseases and conditions. Reach for this title to explain the functions, advancements, and limitations of the science behind the decisions, treatments, and procedures you perform in your practice every day. Use it to build and reinforce your foundation of knowledge for applying advances in scientific discovery to your decision making in the clinic and the OR. This new edition is completely rewritten, reorganized, and refocused through a collaboration of senior scientists and clinicians with new chapters and content reflecting the many advancement in and around the science behind musculoskeletal medicine, including epigenetics, biomaterials, tissue engineering, gender differences, and metabolic bone disease, as well as the growth of registries and best-practice guidelines. Sections include: Basic Disciplines in Orthopaedic Surgery Structure and Function of Musculoskeletal Tissues Pathophysiology and Orthopaedic Medicine Repair and Regeneration Principles of Clinical Information Enrich Your eBook Reading Experience Read directly on your preferred device(s) , such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Title Copyright Acknowledgments Contributors Preface Contents Section 1 Basic Disciplines in Orthopaedic Surgery Chapter 1 Genetics, Gene Expression, and Epigenetics Chapter 2 Cell Biology, Cell Differentiation, and Stem Cells of the Skeletal System Chapter 3 Biology and Mechanics of the Skeletal Extracellular Matrix Chapter 4 Biomechanics of the Skeletal System Chapter 5 Gait and Gait Disturbances Chapter 6 Biomaterials in Orthopaedic Practice Chapter 7 The Biologic Response to Orthopaedic Implants Chapter 8 Osteolysis and Implant Loosening Section 2 Structure and Function of Musculoskeletal Tissues Chapter 9 The Development, Growth, and Morphogenesis of the Skeleton Chapter 10 Biology of Bone Chapter 11 Bone Biomechanics Chapter 12 Biology of Articular Cartilage Chapter 13 Biomechanics of Articular Cartilage and Its Response to Loading Chapter 14 Meniscus and Labrum Chapter 15 Synovium and Joint Biology Chapter 16 Joint Cross-­talk Among Bone, Synovium, and Articular Cartilage Chapter 17 The Intervertebral Disk Chapter 18 Tendons and Ligaments Chapter 19 Form and Function of Skeletal Muscle Chapter 20 Structure and Physiology of Peripheral Nerves Section 3 Pathophysiology and Orthopaedic Medicine Chapter 21 Venous Thromboembolic Disease and Fat Embolism Syndrome Chapter 22 Biology and Diagnosis of Skeletal Infection Chapter 23 Treatment of Skeletal Infections Chapter 24 Sex and Gender Differences in Clinical and Preclinical Studies Chapter 25 Metabolic Bone Diseases Chapter 26 Rare Genetic Bone Diseases of Orthopaedic Significance Chapter 27 Osteonecrosis Chapter 28 Osteoarthritis Chapter 29 Neuromuscular Diseases Chapter 30 Lumbar Spondylosis, Degenerative Disk Disease, and Radiculopathy Section 4 Repair and Regeneration Chapter 31 Fracture Repair Chapter 32 Contemporary Concepts in Soft-­Tissue Wound Management Chapter 33 Articular Cartilage Repair: Augmentation, Regeneration, Replacement, and Substitution Chapter 34 Tendon and Ligament Healing Chapter 35 Skeletal Muscle Repair and Regeneration Chapter 36 Diagnosis and Repair of Peripheral Nerve Injuries Chapter 37 Cells and Materials for Soft-Tissue Repair and Regeneration Section 5 Principles of Clinical Information Chapter 38 Ethics of Clinical Practice in Orthopaedic Surgery Chapter 39 Ethical Principles of Clinical Research Chapter 40 Principles of Clinical Studies Chapter 41 Observational Studies Chapter 42 Randomized Controlled Trials Chapter 43 Systematic Reviews and Meta-­Analysis Chapter 44 Evidence-­Based Medicine and Best-Practice Guidelines Chapter 45 Role of Cohort Studies and Registries in Musculoskeletal Healthcare and Research Chapter 46 Fundamentals of Cost-­Effectiveness Research Chapter 47 The Product Development Process From Discovery, Through the FDA, and Into the Clinic Index "This edition represents the scientific basis of orthopaedic surgery as of 2020. It is intended to inform clinical decision making by providing the basic sciences in a clinically relevant context. The production of the fifth edition of Orthopaedic Basic Science was a substantial undertaking contributed to by each of the authors. The author list is comprised of senior scientists and clinicians, and rising stars, a healthy mixture that reflects well on both sustained personal commitments and expectations for the future. Reflecting the growth in orthopaedic scientific information, all the previously included chapters have been revised and many new chapters have been added. Molecular biology has been refocused to emphasize the role of epigenetics. Biomaterials, repair, and tissue engineering are also emphasized. The significance of articular crosstalk is presented together with new chapters on joint biology and osteoarthritis. Consideration of gender differences in preclinical and clinical studies recognizes the spectrum of biological responses and the presentation of metabolic bone diseases acknowledges the importance of secondary fracture prevention. A completely redone section on the generation of clinical information recognizes advances in methodology, the assessment of large databases and the growth of registries, and best-practice guidelines"-- Provided by publisher The fifth edition of Orthopaedic Basic Science: Foundations of Clinical Practice is your concise and clinically relevant resource for the diagnosis and treatment of musculoskeletal diseases and conditions. This completely rewritten edition explains the functions and limitations of the science behind the decisions, treatments, and procedures you perform in your practice every day. Use it to build and reinforce your foundation of knowledge for applying advances in scientific discovery to your decision-making in the clinic and the OR.