Organolithiums in Enantioselective Synthesis (Topics in Organometallic Chemistry (5))

Content: Arsenic-based drugs : From Fowler's solution to modern anticancer chemotherapy / Stéphan Gilbaud and Gérard Jaouen -- Activation mechanisms for organometallic anticancer complexes / Ana M. Pizarro, Abraha Habtemariam, and Peter J. Sadler -- Organometallic antitumour agents with alternative modes of action / Angela Casini ... [et al.] -- Ferrocene functionalized endocrine modulators as anticancer agents / Elizabeth A. Hillard, Anne Vessieres, and Gerard Jaouen -- Titanocenes : Cytotoxic and anti-angiogenic chemotherapy against advanced renal-cell cancer / Megan Hogan and Matthias Tacke -- Organometallics as structural scaffolds for enzyme inhibitor design / Seann P. Mulcahy and Eric Meggers -- Bioorganometallic chemistry and malaria / Christophe Biot and Daniel Dive -- Biomedical applications of organometal-peptide conjugates / Nils Metzler-Nolte -- Organometallic radiopharmaceuticals / Roger Alberto -- Carbon-monoxide : An essential signaling molecule / Brian E. Mann

Organolithium chemistry occupies a central position in the selective construction of C-C bonds in both simple and complex molecules. Paralleling the surge of interest in methods for asymmetric synthesis, the use of organolithiums in enantioselective synthesis has witnessed spectacular advances in a little over a decade. This volume is the first dedicated to a comprehensive coverage of this important area. It is designed to provide graduate students and researchers with a rich source of essential information on synthesising molecules in an enantioselective manner using organolithiums, and be an inspiration for future developments. Following an overview chapter summarising the key milestones, successive chapters, each written by leading experts in their field, critically survey all the major areas of progress.

pref_fulltext......Page 1 002fulltext......Page 2 021fulltext......Page 22 038fulltext......Page 37 063fulltext......Page 60 140fulltext......Page 137 178fulltext......Page 175 218fulltext......Page 215 252fulltext......Page 249 288fulltext......Page 285 Organolithium chemistry pervades organic chemistry, and aspects of organolithium chemistry have been reviewed on several occasions [1-5].