Organizational biosynthesis : a symposium, held at the Institute of Microbiology of Rutgers - The State University, with support from the National Science Foundation

Organizational Biosynthesis focuses on the organized biosynthesis of the bacterial chromosome and examines the fundamental aspects of this process. This book discusses the basic particles of biology, which are explored in terms of organizational biosynthetic events at the molecular level. Organized into 10 parts encompassing 45 chapters, this book starts with an overview of how cellular components recognize, coordinate, and interact with each other during cellular division and genetic recombination. This text then examines the biochemical experiments with bacteria, which strongly suggest the participation of a particulate fraction. Other chapters consider the molecular basis for the physical continuity of the chromosome. This book discusses as well the result of the experiments for bacteria, which shows that DNA replication can proceed only after both template strands of the replicating molecule attach to the cell. The final chapter deals with protein biosynthesis system in mitochondria. This book is a valuable resource for biologists and biochemists. Content: Front Matter , Page iii Copyright , Page iv List of Participants , Pages v-xiv Preface , Page xv , HENRY J. VOGEL, J. OLIVER LAMPEN, VERNON BRYSON Introductory Remarks , Page 1 , J. OLIVER LAMPEN Opening Address: Molecular Technology , Pages 3-14 , FRITZ LIPMANN Chairman's Remarks , Page 17 , C.A. THOMAS JR. Particulate Fractions in Macromolecular Synthesis and Genetic Transformation , Pages 19-47 , A.T. GANESAN The Bacterial Chromosome as a Unit of Structure and Replication , Pages 49-61 , CEDRIC DAVERN, JOHN CAIRNS, PAULA DE LUCIA, ANN GUNSALUS Chromosome Segregation and the Regulation of DNA Replication , Pages 63-89 , K.G. LARK, HELEN EBERLE, R.A. CONSIGLI, H.C. MINOCHA, N. CHAI, C. LARK Discussion of Part I , Pages 91-94 , C.A. THOMAS, O.E. LANDMAN, A.T. GANESAN, E. RACKER, J.K. BHATTACHARJEE, D. BILLEN, C.I. DAVERN, H.V. APOSHIAN, F. LIPMANN, C.B. ANFINSEN, P. SIEKEVITZ, M. RILEY, K.G. LARK, R.P. NOVICK, N. SUEOKA Chairman's Remarks , Page 97 , SAMUEL B. WEISS Coupled Regulation of Bacterial RNA and Protein Synthesis , Pages 99-109 , GUNTHER S. STENT Interdependence of Translation and Transcription in T4-Infected Escherichia coli , Pages 111-123 , T. KASAI, E.K.F. BAUTZ Discussion of Part II , Pages 125-126 , S.B. WEISS, J.K. BHATTACHARJEE, G.S. STENT, C.A. THOMAS, T. KASAI, R.P. NOVICK Chairman's Remarks , Pages 129-130 , ALEXANDER RICH Bacterial Amino Acid Polymerization , Pages 131-142 , FRITZ LIPMANN, YASUTOMI NISHIZUKA, JULIAN GORDON, JEAN LUCAS-LENARD, MAX GOTTESMAN On the Problem of Autocomplementarity in Messenger RNA , Pages 143-149 , ALEXANDER RICH Discussion of Part III , Page 151 , H.J. VOGEL, A. RICH Chairman's Remarks , Page 155 , R. WALTER SCHLESINGER Some Interrelations of Natural Polyamines and Nucleic Acids in Growing and Virus-Infected Bacteria , Pages 157-182 , SEYMOUR S. COHEN, AARNE RAINA Discussion of Part IV , Pages 183-184 , R.W. SCHLESINGER, K.G. LARK, S.S. COHEN, D. NAKADA, R.L. METZENBERG, K.R. HANSON, A. NASON Chairman's Remarks , Page 187 , NOBORU SUEOKA The Biosynthesis of l -Cysteine in Escherichia coli and Salmonella typhimurium by a Multifunctional Enzyme Complex , Pages 189-198 , NICHOLAS M. KREDICH, GORDON M. TOMKINS Derepression and Repression of the Histidine Operon: Sequential and Simultaneous Modes , Pages 199-222 , ROBERT F. GOLDBERGER, MARY ANNE BERBERICH Gene-Ribosome-Enzyme Organization in the Arginine System of Escherichia coli , Pages 223-234 , H.J. VOGEL, S. BAUMBERG, D.F. BACON, E.E. JONES, L. UNGER, R.H. VOGEL Discussion of Part V , Pages 235-237 , F. LYNEN, N.M. KREDICH, E. RACKER, R.F. GOLDBERGER, R.O. BURNS, H.J. VOGEL, F. LIPMANN, M. RILEY, P. ROGERS, J.R. MATTOON, M. SCHAECHTER, N. SUEOKA Chairman's Remarks , Page 241 , CHRISTIAN B. ANFINSEN Multienzyme Complex of Fatty Acid Synthetase , Pages 243-266 , FEODOR LYNEN, ALEXANDER HAGEN, INGRID HOPPER-ESSEL, DIETER OESTERHELT, HENRY C. REEVES, ECKHART SCHWEIZER, KLAUS WILLECKE, MOHAMED YALPANI The Synthesis of Amino Acids by Organized Enzyme Systems , Pages 267-293 , R.P. WAGNER, A. BERGQUIST, B. BROTZMAN, E.A. EAKIN, C.H. CLARKE, R.N. LE PAGE On the Role of Glucose-6-phosphate Dehydrogenase in the Morphology of Neurospora , Pages 295-301 , STUART BRODY, E.L. TATUM Channeling in Neurospora Metabolism , Pages 303-322 , ROWLAND H. DAVIS Discussion of Part VI , Pages 323-325 , C.B. ANFINSEN, F. LIPMANN, F. LYNEN, K. BLOCH, R.Y. HSU, M. LEVINTHAL, R.P. WAGNER, D. PRAMER, S. BRODY, P. SIEKEVITZ, J.R. MATTOON, J.K. BHATTACHARJEE Chairman's Remarks , Page 329 , F. LYNEN The Biogenesis of Intracellular Membranes , Pages 331-362 , PHILIP SIEKEVITZ, GEORGE E. PALADE, GUSTAV DALLNER, ITHAK OHAD, TSUNEO OMURA Invertase Biosynthesis and the Yeast Cell Membrane , Pages 363-372 , J. OLIVER LAMPEN, NORBERT P. NEUMANN, SANTIAGO GASCON, BLAND S. MONTENECOURT Control of Membrane Differentiation and Quantum Conversion Efficiency in Chloroplasts , Pages 373-385 , RODERIC B. PARK Discussion of Part VII , Pages 387-389 , F. LYNEN, E. RACKER, P. SIEKEVITZ, K.G. LARK, J.O. LAMPEN, A.W. GALSTON, R.B. PARK Chairman's Remarks , Page 393 , KONRAD BLOCH Aspects of Chloroplast Assembly , Pages 395-418 , LAWRENCE BOGORAD The Nucleic Acids Associated with the Chloroplasts of Euglena gracilis and Their Role in Protein Synthesis , Pages 419-434 , GEORGE BRAWERMAN, JEROME M. EISENSTADT Discussion of Part VIII , Pages 435-437 , K. BLOCH, R.B. PARK, L. BOGORAD, A.W. GALSTON, J.R. WARNER, O.E. LANDMAN, G. BRAWERMAN, F.F. DAVIS, R.O. BURNS Chairman's Remarks , Page 441 , RICHARD B. ROBERTS Taking the Ribosome Apart and Putting It Back Together Again , Pages 443-457 , THEOPHIL STAEHELIN, HESCHEL RASKAS, MATTHEW MESELSON Structure and Function of Ribosomes and Subribosomal Particles , Pages 459-476 , M. NOMURA, P. TRAUB The Preparation of Protein-Depleted Particles from Rat Liver Ribosomes , Pages 477-479 , ANNE-MARIE REBOUD, MARY L. PETERMANN Discussion of Part IX , Pages 481-484 , R.B. ROBERTS, P. SIEKEVITZ, M. NOMURA, T. STAEHELIN, J. MARMUR, E. RACKER, M. MESELSON, R.P. NOVICK Chairman's Remarks , Pages 487-488 , EFRAIM RACKER Genetic Control, Function, and Assembly of a Structural Protein in Neurospora , Pages 489-502 , Dow O. WOODWARD, K.D. MUNKRES Circularity and Other Properties of Mitochondrial DNA of Animal Cells , Pages 503-522 , MARGIT M.K. NASS Discussion of Part X , Pages 523-526 , E. RACKER, M.V. SIMPSON, M. MESELSON, M.M.K. NASS, P. SIEKEVITZ, D.O. WOODWARD, N. NEUMANN, S. GRANICK Author Index , Pages 527-540 Subject Index , Pages 541-549