Organic synthesis : theory and applications. Vol. 5 / editor, Tomas Hudlicky

__Organic Synthesis, Fourth Edition__, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the __Fourth Edition,__ the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, __Organic Synthesis, Fourth Edition__ utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors.

Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.

In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry.

Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching.

• Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association
• Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts
• Includes reaction examples taken from literature research reported between 2010-2015
• Features new full-color art and new chapter content on process chemistry and green organic chemistry
• Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors

Content: Front Matter,Copyright,About the Author,Preface to the Fourth Edition,Preface to the Third Edition,Preface to the First Edition. Why I Wrote This Book!,Common AbbreviationsEntitled to full textChapter 1 - Retrosynthesis, Stereochemistry, and Conformations, Pages 1-60 Chapter 2 - Acids, Bases, and Addition Reactions, Pages 61-95 Chapter 3 - Functional Group Exchange Reactions: Aliphatic and Aromatic Substitution and Elimination Reactions, Pages 97-160 Chapter 4 - Acids, Bases, and Functional Group Exchange Reactions: Acyl Addition and Acyl Substitution, Pages 161-183 Chapter 5 - Functional Group Exchange Reactions: Protecting Groups, Pages 185-213 Chapter 6 - Functional Group Exchange Reactions: Oxidations, Pages 215-307 Chapter 7 - Functional Group Exchange Reactions: Reductions, Pages 309-418 Chapter 8 - Synthetic Strategies, Pages 419-482 Chapter 9 - Functional Group Exchange Reactions: Hydroboration, Pages 483-518 Chapter 10 - Functional Group Exchange Reactions: Selectivity, Pages 519-546 Chapter 11 - Carbon-Carbon Bond-Forming Reactions: Cyanide, Alkyne Anions, Grignard Reagents, and Organolithium Reagents, Pages 547-603 Chapter 12 - Carbon-Carbon Bond-Forming Reactions: Stabilized Carbanions, Organocuprates, and Ylids, Pages 605-657 Chapter 13 - Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions, Pages 659-742 Chapter 14 - Pericyclic Reactions: The Diels-Alder Reaction, Pages 743-800 Chapter 15 - Pericyclic Reactions: [m+ n]-Cycloadditions, Sigmatropic Rearrangements, Electrocyclic, and Ene Reactions, Pages 801-861 Chapter 16 - Carbon-Carbon Bond-Forming Reactions: Carbocation and Oxocarbenium Ion Intermediates, Pages 863-915 Chapter 17 - Formation of Carbon-Carbon Bonds Via Radicals and Carbenes, Pages 917-980 Chapter 18 - Metal-Mediated, Carbon-Carbon Bond-Forming Reactions, Pages 981-1023 Chapter 19 - Combinatorial and Process Chemistry, Pages 1025-1054 Subject Index, Pages 1055-1079 Disconnection Index, Pages 1081-1083