Organic reactions in water: principles, strategies and applications / edited by U. Marcus Lindström

Volatile organic solvents are the normal media used in both research scale and industrial scale synthesis of organic chemicals. Their environmental impact is significant, however, and so the development of alternative reaction media has become of great interest. Developments in the use of water as a solvent for organic synthesis have reached the point where it could now be considered a viable solvent for many organic reactions. Organic Reactions in Water demonstrates the underlying principles of using water as a reaction solvent and, by reference to a range of reaction types and systems, it's effective use in synthetic organic chemistry. Written by an internationally respected team of contributors, and with a strong focus on the practical use of water as a reaction medium, this book illustrates the enormous potential of water for the development of new and unique chemistries and synthetic strategies, while at the same time offering a much reduced environmental impact. Cover Page 1 Title: Organic Reactions in Water 3 ISBN 1405138904 4 Contents (with page links) 5 1 A Fifty-Year Perspective on Chemistry inWater 5 2 Structure and Properties ofWater 5 3 Acid Catalysis inWater 5 4 Metal-Mediated C C Bond Formations in Aqueous Media 6 5 Pericyclic Reactions in AqueousMedia 7 6 Catalyzed Reductions in AqueousMedia 7 7 Oxidations 7 8 Nucleophilic Additions and Substitutions inWater 8 9 Reactions in NearcriticalWater 8 10 Biocatalysis inWater 8 11 Chemistry ‘OnWater’ – Organic Synthesis in Aqueous Suspension 10 12 Water As a Reaction Solvent – An Industry Perspective 10 Contributors 11 Preface 13 Foreword 16 1 A Fifty-Year Perspective on Chemistry in Water 17 2 Structure and Properties of Water 45 3 Acid Catalysis in Water 76 4 Metal-Mediated C––C Bond Formations in Aqueous Media 108 5 Pericyclic Reactions in Aqueous Media 162 6 Catalyzed Reductions in Aqueous Media 201 7 Oxidations 231 8 Nucleophilic Additions and Substitutions in Water 252 9 Reactions in Nearcritical Water 272 10 Biocatalysis in Water 317 11 Chemistry ‘On Water’ – Organic Synthesis in Aqueous Suspension 366 12 Water as a Reaction Solvent – An Industry Perspective 382 Index of Organic Reactions in Water 414 Index (with page links) 417 "Organic Reactions in Water demonstrates the underlying principles of using water as a reaction solvent and, by reference to a range of reaction types and systems, its effective use in synthetic organic chemistry. Written by an internationally respected team of contributors and with a strong focus on the practical use of water as a reaction medium, this book illustrates the enormous potential of water for the development of new and unique chemistries and synthetic strategies, whilst at the same time offering a much reduced environmental impact." --Résumé de l'éditeur 'Organic Reactions in Water' brings non-experts up-to-speed quickly and comprehensively, facilitating the use of water as a reaction solvent in both research scale and production scale organic synthesis