Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition, Second Edition

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style. Read more... Abstract: The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Illustrates the organic mechanism associated with each enzyme-catalyzed reaction
Makes the connection between organic reaction mechanisms and enzyme mechanisms
Compiles the latest information about molecular mechanisms of enzyme reactions
Accompanied by clearly drawn structures, schemes, and figures
Includes an extensive bibliography on enzyme mechanisms covering the last 30 years
Explains how enzymes can accelerate the rates of chemical reactions with high specificity
Provides approaches to the design of inhibitors of enzyme-catalyzed reactions
Categorizes the cofactors that are appropriate for catalyzing different classes of reactions
Shows how chemical enzyme models are used for mechanistic studies
Describes catalytic antibody design and mechanism
Includes problem sets and solutions for each chapter
Written in an informal and didactic style Content: Front Matter , Page iii Copyright , Page iv Dedication , Page v Preface , Pages xiii-xv , Richard B. Silverman About the Author , Page xvii CHAPTER 1 - Enzymes as Catalysts , Pages 1-38 CHAPTER 2 - Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation , Pages 39-94 CHAPTER 3 - Reduction and Oxidation , Pages 95-174 CHAPTER 4 - Monooxygenation , Pages 175-226 CHAPTER 5 - Dioxygenation , Pages 227-249 CHAPTER 6 - Substitutions , Pages 251-287 CHAPTER 7 - Carboxylations , Pages 289-320 CHAPTER 8 - Decarboxylation , Pages 321-357 CHAPTER 9 - Isomerizations , Pages 359-397 CHAPTER 10 - Eliminations and Additions , Pages 399-452 CHAPTER 11 - Aldol and Claisen Reactions and Retroreactions , Pages 453-478 CHAPTER 12 - Formylations, Hydroxymethylations, and Methylations , Pages 479-503 CHAPTER 13 - Rearrangements , Pages 505-561 APPENDIX I - Enzyme Kinetics , Pages 563-596 APPENDIX II - Problems and Solutions , Pages 597-696 Index , Pages 697-717 Segel has given a fascinating historical perspective on the discovery of enzymes; some of the notable events are mentioned here.