Oral Precancer: Thomson/Oral Precancer

**__Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions.__** Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oralcancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, **__Oral Precancer__**: * **Reviews** current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases * **Explains** the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity * **Details** a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma * **Contains** a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, **__Oral Precancer__** offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions. Content: Chapter 1 Introduction (pages 1–12): Peter ThomsonChapter 2 Form and Function of the Oral Mucosa (pages 13–30): C. Max Robinson and Peter ThomsonChapter 3 Oral Carcinogenesis (pages 31–47): Peter ThomsonChapter 4 Clinical Presentation of Oral Precancer (pages 48–74): Peter Thomson and Michaela L. GoodsonChapter 5 Diagnostic Methods (pages 75–92): Peter Thomson and Michaela L. GoodsonChapter 6 Pathological Aspects of Oral Precancer (pages 93–106): Philip SloanChapter 7 Management of Oral Precancer (pages 107–137): Peter ThomsonChapter 8 Clinical Outcome (pages 138–155): Peter ThomsonChapter 9 Malignant Transformation and Oral Cancer Development (pages 156–169): Peter ThomsonChapter 10 The Future (pages 170–185): Peter Thomson and Michaela L. GoodsonChapter 11 Case Histories (pages 186–206): Peter Thomson and Philip SloanChapter 12 Conclusions (pages 207–212): Peter Thomson Oral Precancer......Page 1 Oral Precancer......Page 2 Contents......Page 4 List of Contributors......Page 8 Preface......Page 9 Acknowledgements......Page 11 1. Introduction......Page 12 General introduction......Page 13 Epidemiology......Page 17 Prevalence of oral leukoplakia......Page 18 Prevention......Page 19 Terminology......Page 20 Summary......Page 22 References......Page 23 2. Form and Function of the Oral Mucosa......Page 24 Applied anatomy of the oral cavity......Page 25 Microanatomy of the oral mucosa......Page 28 Lining mucosa......Page 30 Masticatory mucosa......Page 32 Specialised mucosa......Page 33 Oral epithelial cell kinetics......Page 34 Oral epithelial cell proliferative activity......Page 36 Summary......Page 40 References......Page 41 3. Oral Carcinogenesis......Page 42 Introduction......Page 43 Oral cancer and precancer......Page 44 The ‘progression model’ for oral cancer......Page 47 Aetiology and risk factors......Page 49 Tobacco......Page 50 Diet and nutrition......Page 53 Other risk factors......Page 54 Patient and risk factor profiling......Page 55 Summary......Page 56 References......Page 57 4. Clinical Presentation of Oral Precancer......Page 59 Clinical terminology......Page 60 Leukoplakia......Page 62 Erythroplakia......Page 70 Erythroleukoplakia......Page 71 High-risk clinical appearance......Page 72 Immunosuppression......Page 74 Lichen planus and lichenoid lesions......Page 75 Oral submucous fibrosis......Page 77 Actinic cheilitis......Page 79 Chronic hyperplastic candidosis candidal leukoplakia......Page 80 Dyskeratosis congenita......Page 81 Multiple lesion disease......Page 82 References......Page 84 5. Diagnostic Methods......Page 86 Screening......Page 87 Clinical examination techniques......Page 88 Vital tissue staining......Page 95 Light-based detection systems......Page 96 Brush biopsy and exfoliative cytology......Page 99 References......Page 102 6. Pathological Aspects of Oral Precancer......Page 104 Biopsy techniques......Page 105 Role of the pathologist......Page 107 Histopathological features of oral potentially malignant disorders......Page 108 World health organisation system......Page 110 Squamous intraepithelial neoplasia system......Page 113 Combining the grading systems......Page 114 Limitations in conventional pathological techniques......Page 115 References......Page 116 7. Management of Oral Precancer......Page 118 Introduction......Page 119 Smoking cessation......Page 120 Alcohol counselling......Page 121 Observation versus intervention......Page 122 Medical treatment......Page 123 Surgical treatment......Page 124 Interventional laser surgery......Page 125 Surgical techniques......Page 126 Laser excision versus ablation......Page 140 Complications of laser surgery......Page 141 Patient follow up and surveillance......Page 145 Summary......Page 146 References......Page 147 8. Clinical Outcome......Page 149 Clinical outcome studies......Page 150 Patient cohort studies......Page 152 Clinical resolution disease-free state......Page 153 Persistent disease......Page 154 Recurrent disease same-site recurrence......Page 155 Newcastle patient cohort studies......Page 156 Observational study Goodson et al. 2008......Page 157 The Newcastle 10-year follow-up study Diajil 2011......Page 158 Patient follow up......Page 160 Prediction of clinical outcome......Page 161 References......Page 166 9. Malignant Transformation and Oral Cancer Development......Page 167 Introduction......Page 168 Risk of progression to oral carcinoma......Page 169 Malignant transformation versus oral cancer development......Page 172 Interventional laser surgery and oral cancer prevention......Page 174 Newcastle 10-year follow-up study......Page 175 Clinical signs of oral squamous cell carcinoma......Page 176 Diagnosis and management of ‘unexpected malignancy’......Page 178 Summary......Page 179 References......Page 180 10. The Future......Page 181 Introduction......Page 182 Tobacco and alcohol use......Page 183 Human papillomavirus......Page 184 Early diagnosis of potentially malignant disease......Page 185 Interventional management strategies in the future......Page 186 Individualised patient treatments: biomarkers and targeted chemoprevention......Page 189 Scientific research......Page 190 Translational research......Page 193 Summary......Page 194 References......Page 195 11. Case Histories......Page 197 Management......Page 198 Clinical outcome......Page 199 Clinical presentation......Page 200 Comment......Page 201 Management......Page 202 Management......Page 203 Comment......Page 204 Management......Page 205 Clinical presentation......Page 206 Clinical presentation......Page 207 Management......Page 208 Histopathological diagnosis......Page 209 Clinical presentation......Page 210 Clinical outcome......Page 211 Clinical presentation......Page 212 Comment......Page 213 Clinical presentation and history......Page 214 Clinical outcome......Page 215 Summary......Page 216 12. Conclusions......Page 218 Clinical management......Page 219 Patient care pathways......Page 221 Future directions......Page 222 Index......Page 224 Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer : Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions. Content: Chapter 1 Introduction (pages 1–12): Peter Thomson Chapter 2 Form and Function of the Oral Mucosa (pages 13–30): C. Max Robinson and Peter Thomson Chapter 3 Oral Carcinogenesis (pages 31–47): Peter Thomson Chapter 4 Clinical Presentation of Oral Precancer (pages 48–74): Peter Thomson and Michaela L. Goodson Chapter 5 Diagnostic Methods (pages 75–92): Peter Thomson and Michaela L. Goodson Chapter 6 Pathological Aspects of Oral Precancer (pages 93–106): Philip Sloan Chapter 7 Management of Oral Precancer (pages 107–137): Peter Thomson Chapter 8 Clinical Outcome (pages 138–155): Peter Thomson Chapter 9 Malignant Transformation and Oral Cancer Development (pages 156–169): Peter Thomson Chapter 10 The Future (pages 170–185): Peter Thomson and Michaela L. Goodson Chapter 11 Case Histories (pages 186–206): Peter Thomson and Philip Sloan Chapter 12 Conclusions (pages 207–212): Peter Thomson "Oral Precancer is a preeminent new book that compiles recent research on precancer conditions of the oral cavity and their specific application to the dental field. In addition to providing a scientific and evidence-based survey of the disparate sources of oral precancer research, this book presents practical information for dental practitioners. Written by a prominent researcher in the field, Oral Precancer furnishes its readers with a balanced approach to this highly topical subject"--Provided by publisher. "Oral Precancer is a preeminent new book that compiles recent research on precancer conditions of the oral cavity and their specific application to the dental field. In addition to providing a scientific and evidence-based survey of the disparate sources of oral precancer research, this book presents practical information for dental practitioners. Written by a prominent researcher in the field, Oral Precancer furnishes its readers with a balanced approach to this highly topical subject"-- Provided by publisher "Oral Precancer is a preeminent new book that compiles recent research on precancer conditions of the oral cavity and their specific application to the dental field. In addition to providing a scientific and evidence-based survey of the disparate sources of oral precancer research, this book presents practical information for dental practitioners. Written by a prominent researcher in the field, Oral Precancer furnishes its readers with a balanced approach to this highly topical subject"--Résumé de l'éditeur