Opportunities and challenges for metal chemistry in molecular imaging: from gamma camera imaging to PET and multimodality imaging

The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this article illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the article is the shift from single photon radionuclide imaging towards PET, and in turn the emerging shift from PET/CT towards PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short lived (Ga-68) and long-lived (Zr-89) positron emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabelled iron oxide based nanoparticles. This volume will be of interest to those involved in medical and health related research, as well as biomedical scientists. The imaging technologies included also have considerable relevance to a wider audience interested in diagnostic and therapeutic methods related to diseases of considerable public concern. It has a predominant theme of metal ions in medical imaging, but also covers traditional inorganic chemistry in its discussion of the rationale for the choice of metal ions in particular contexts, and the relevant coordination chemistry. Discussions include the design of suitable chelating ligands for the metal complex applications, and of creative ideas in organic synthesis that would lead to complexes with the desired properties. Also covered are methods and techniques used in biomedical science to exploit the properties of the species produced for imaging. Complexes for magnetic resonance, luminescent metal complexes, metalloporphyrins and radiopharmaceutical complexes are highlighted. The scientific content ranges from in vitro coordination chemistry to in vivo treatment in clinical practice. Research presented in this volume is valuable in diagnosis and therapy in the field of biomedical science and in public health services Insights from Imaging in Bioinorganic Chemistry continues a long-running series that describes recent advances in scientific research, in particular, in the field of inorganic chemistry. Several highly regarded experts, mostly from academe, contribute on specific topics. The series editor chooses a sub-field within inorganic chemistry as the theme and focus of the volume, extending invitations to experts for their contributions; the current theme is insights from metal ion imaging in bioinorganic and medicinal chemistry.

• Contains concise, informative accounts that are not too highly specialized, therefore appealing to a wide range of scientists and health professionals
• Presents contributions from highly qualified international experts
• Provides intrinsic scientific interest and applications, including important issues relating to the diagnosis and therapeutics that are relevant to public health

Insights from Imaging in Bioinorganic Chemistry continues a long-running series that describes recent advances in scientific research, in particular, in the field of inorganic chemistry. Several highly regarded experts, mostly from academe, contribute on specific topics. The series editor chooses a sub-field within inorganic chemistry as the theme and focus of the volume, extending invitations to experts for their contributions; the current theme is insights from metal ion imaging in bioinorganic and medicinal chemistry. Contains concise, informative accounts that are not too highly specialized, therefore appealing to a wide range of scientists and health professionals Presents contributions from highly qualified international experts Provides intrinsic scientific interest and applications, including important issues relating to the diagnosis and therapeutics that are relevant to public health Annotation This volume continues a long-running series that describes recent advances in scientific research, in particular, in the field of inorganic chemistry. Several highly regarded experts, mostly from academe, contribute on specific topics