Opioids in medicine : a systematic and comprehensive review on the mode of action and the use of analgesics in different clinical pain states

Use of opioids in pain medicine is a rapidly expanding speciality especially since pain pharmacotherapy as a continuum of care is an essential asset in pain medicine. The book has been conceived to fill the void for a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine. While the information provided is obtainable in other major text already in print, the present format style plus the illustrations will make easy reading and fast accessibility of information on opioids available. Information provided is based on clinical practice rather than pure experimental data giving the clinician something at hand, which is useful in daily practice. Wherever required, the mechanisms of action of pain pharmacotherapy are described in detail and references are provided to give the reader further sources for additional information. As a special feature of the book, self-explanatory figures result in an immediate clarification of the mode of action of central analgesics, thus avoiding the usual long and fatigueing text in common standard pain books. A table of contents rapidly leads the reader from general issues of pain to specific pain syndromes and their management, putting the emphasis on the practical does and dont??s, with special reference to lawful prescribing and preventing diversion of opioid use. The book centers on the treatment of pain using the appropriate opioid and a suitable co-medication whenever necessary. While many physicians or health care providers either subscribe or advocate analgesics in response to a painful situation, their basic knowledge when and how to apply them frequently is scarce. And often there is a lack of sufficient knowledge on their potential side-effects, their mode of action, 2+ their possible interactions with other agents such as ß-blockers, Ca -antagonists, ACE inhibitors and/or benzodiazepines. In addition, not all analgesics are equivalent or equally proficient at alleviating certain painful ailments. Although there have been many of articles and books written on the subject of effective pain treatment, very few have centered on the rational use of opioids. In fact opiophobia is still around with some caregivers who consider an opioid not to be the first-line drug in severe pain. On the contrary, the myth is still around that an opioid is potentially dangerous even when used in serious painful situations, and although the WHO has stated that opioids are elementary in therapeutic strategy taking into account that they are used by mouth, by the ladder, at fixed time intervals and advocating a time consistent release formulation, they are not available in every country. "The book has been conceived to fill the void for a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine. While the information provided is obtainable in other major text already in print, the present format style plus the illustrations will make easy reading and fast accessibility of information on opioids available. Information provided is based on clinical practice rather than pure experimental data giving the clinician something at hand, which is useful in daily practice. Wherever required, the mechanisms of action of pain pharmacotherapy are described in detail and references are provided to give the reader further sources for additional information." "As a special feature of the book, self-explainable figures result in an immediate clarification of the mode of action of central analgesics, thus avoiding the usual long and fatigueing text in common standard pain books."--Jacket This book fills the void to provide a comprehensive review of the theoretical knowledge and scope of opioid pharmacotherapy in pain medicine. While the information provided is obtainable in other major texts already in print, the present format style plus the illustrations will make easy reading and fast accessibility of information on opioids available. Information provided is based on clinical practice rather than pure experimental for use in daily practice. Front Matter....Pages I-XII Rational for the Use of Opioids in Nociceptive Transmission....Pages 1-84 Mechanism of Action of Opioids and Clinical Effects....Pages 85-187 Opioids, an Integrative Part in Perioperative Medicine....Pages 189-315 Use of Potent Opioids for Chronic Pain Management....Pages 317-409 Detection of Illicit Use of Opioids in Primary Care....Pages 411-468 Back Matter....Pages 469-475 0freypre.pdf -1 0frey0I.pdf -1 0frey0II.pdf -1 0frey0iii.pdf -1 0frey0IV.pdf -1 0freyV.pdf -1 0Frey_Index.pdf -1