Opioid Peptides: Biology, Chemistry, and Genetics : The Peptides: Analysis, Synthesis, Biology, Vol. 6

The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activity relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins. Content: THE PEPTIDES: Analysis, Synthesis, Biology, Page ii Front Matter, Page iii Copyright, Page iv Contributors, Pages ix-x Preface, Pages xi-xii, Johannes Meienhofer Introduction, Page xiii, Sidney Udenfriend Nomenclature and Abbreviations, Pages xv-xix Structures of Opiates and Related Nonpeptide Receptor Ligands Discussed in the Text, Pages xxi-xxviii Opioid Peptides with Special Names, Pages xxix-xxx Contents of Previous Volumes, Pages xxxi-xxxv Chapter 1 - Opioid Peptide Precursors and Their Genes, Pages 1-23, SHOSAKU NUMA Chapter 2 - Proenkephalin and the Products of Its Processing: Chemistry and Biology, Pages 25-68, SIDNEY UDENFRIEND, DANIEL L. KILPATRICK Chapter 3 - Pro-opiomelanocortin: A Polyprotein at the Interface of the Endocrine and Nervous Systems, Pages 69-94, OLIVER CIVELLI, JAMES DOUGLASS, EDWARD HERBERT Chapter 4 - Biology and Chemistry of the Dynorphin Peptides, Pages 95-145, AVRAM GOLDSTEIN Chapter 5 - Opioid Receptors, Pages 147-189, STEWART J. PATERSON, LINDA E. ROBSON, HANS W. KOSTERLITZ Chapter 6 - β-Endorphin: Structure and Activity, Pages 191-217, DONALD YAMASHIRO, CHOH HAO LI Chapter 7 - Conformational Analysis of Enkephalin and Conformation – Activity Relationships, Pages 219-268, PETER W. SCHILLER Chapter 8 - Structure – Activity Relationships in Enkephalin Peptides, Pages 269-321, PHILIP E. HANSEN, BARRY A. MORGAN Chapter 9 - Opioid Peptides in Humans and Their Clinical Significance, Pages 323-389, VICKY CLEMENT-JONES, G.M. BESSER Index, Pages 391-410