Oncofertility: Fertility Preservation for Cancer Survivors (Cancer Treatment and Research Book 138)

While cancer survival rates have increased steadily over the last several decades, particularly among younger patients, the more aggressive forms of treatment that have made this possible often compromise a cancer patient's ability to later have biological children. In the past, pregnancy after cancer was largely unheard of. Today it is increasingly a possibility due to high survivorship rates in general and emerging reproductive technologies that give patients and their families options at the time of diagnosis to ensure a patient's future fertility (cryopreservation of ovarian tissue). Oncofertility has emerged as an interdisciplinary field bridging biomedical, social sciences and examines issues regarding an individual's fertility options, choice and goals in light of cancer diagnosis, treatment and survivorship. Written by leaders in this evolving field, the volume covers various aspects: medical, ethical and social. \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* __"Fertility is often a major concern for cancer survivors. This text addresses the complex reproductive issues associated with the treatment of malignant diseases. Recognized leaders in the field discuss scientific advances, application of modern technology, psychosocial implications, ethical considerations, and current options for men and women confronted with therapies that affect fertility."__ __Steven T. Rosen, M.D.__ __Series Editor__ Part I. Introduction Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee -- Yasmin Gosiengfiao -- Part IV. Health care decision-making Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee -- Yasmin Gosiengfiao -- Part IV. Health care decision-making -- Karrie Ann Snyder Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee -- Yasmin Gosiengfiao -- Part IV. Health care decision-making -- Karrie Ann Snyder -- Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston -- Part V. Ethical and psychosocial impact of cancer-related infertility Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee -- Yasmin Gosiengfiao -- Part IV. Health care decision-making -- Karrie Ann Snyder -- Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston -- Part V. Ethical and psychosocial impact of cancer-related infertility -- Leilah E. Backhus and Laurie Zoloth Part I. Introduction -- Teresa K. Woodruff -- Part II. Fertility risk and treatment options -- Sanjay K. Agarwal and R. Jeffrey Chang -- Robert E. Brannigan -- Kimberley J. Dilley -- Clarisa R. Gracia and Jill P. Ginsberg -- Part III. Oncofertility techniques and research -- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea -- Steven F. Muller and John K. Critser -- David Lee -- Yasmin Gosiengfiao -- Part IV. Health care decision-making -- Karrie Ann Snyder -- Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston -- Part V. Ethical and psychosocial impact of cancer-related infertility -- Leilah E. Backhus and Laurie Zoloth -- Matthew J. Loscalzo and Karen L. Clark Part I. Introduction-- Teresa K. Woodruff-- Part II. Fertility risk and treatment options-- Sanjay K. Agarwal and R. Jeffrey Chang-- Robert E. Brannigan-- Kimberley J. Dilley-- Clarisa R. Gracia and Jill P. Ginsberg-- Part III. Oncofertility techniques and research-- Min Xu, Teresa K. Woodruff, and Lonnie D. Shea-- Steven F. Muller and John K. Critser-- David Lee-- Yasmin Gosiengfiao-- Part IV. Health care decision-making-- Karrie Ann Snyder-- Marla L. Clayman, Kathleen M. Galvin, and Paul Arnston-- Part V. Ethical and psychosocial impact of cancer-related infertility-- Leilah E. Backhus and Laurie Zoloth-- Matthew J. Loscalzo and Karen L. Clark-- Karen E. Kinahan, Aarati Didwania, and Carrie L. Nieman Carrie L. Nieman ... [et al.] -- Part VI. Training in a new medical discipline and medical guidelines Carrie L. Nieman ... [et al.] -- Part VI. Training in a new medical discipline and medical guidelines -- Laxmi A. Kondapalli Carrie L. Nieman ... [et al.] -- Part VI. Training in a new medical discipline and medical guidelines -- Laxmi A. Kondapalli -- Leilah E. Backhus ... [et al.] -- Part VII. Patient stories and oncofertility Carrie L. Nieman ... [et al.]-- Part VI. Training in a new medical discipline and medical guidelines-- Laxmi A. Kondapalli-- Leilah E. Backhus ... [et al.]-- Part VII. Patient stories and oncofertility-- provided by Fertile Hope. Front Matter....Pages i-xviii Front Matter....Pages 1-1 The Emergence of a New Interdiscipline: Oncofertility....Pages 3-11 Front Matter....Pages 13-13 Fertility Management for Women With Cancer....Pages 15-27 Fertility Preservation in Adult Male Cancer Patients....Pages 28-49 Managing Fertility in Childhood Cancer Patients....Pages 50-56 Fertility Risk in Pediatric and Adolescent Cancers....Pages 57-72 Front Matter....Pages 73-73 Bioengineering and the Ovarian Follicle....Pages 75-82 The Science of Cryobiology....Pages 83-109 Ovarian Tissue Cryopreservation and Transplantation: Banking Reproductive Potential for the Future....Pages 110-129 Progress, History and Promise of Ovarian Cryopreservation and Transplantation for Pediatric Cancer Patients....Pages 130-134 Front Matter....Pages 135-135 Oncofertility and the Social Sciences....Pages 137-148 Shared Decision Making: Fertility and Pediatric Cancers....Pages 149-160 Front Matter....Pages 161-161 Today's Research, Tomorrows Cures: The Ethical Implications of Oncofertility....Pages 163-179 The Psychosocial Context of Cancer-Related Infertility....Pages 180-190 Childhood Cancer: Fertility and Psychosocial Implications....Pages 191-200 Fertility Preservation and Adolescent Cancer Patients: Lessons from Adult Survivors of Childhood Cancer and Their Parents....Pages 201-217 Front Matter....Pages 219-219 Oncofertility: A New Medical Discipline and the Emerging Scholar....Pages 221-234 Oncofertility Consortium Consensus Statement: Guidelines for Ovarian Tissue Cryopreservation....Pages 235-239 Front Matter....Pages 241-241 Personal Accounts of Cancer and Infertility....Pages 243-248 Back Matter....Pages 249-262 It has been our pleasure to edit the first book on an interdisciplinary science we call oncofertility. Oncofertility bridges traditional areas of basic science and medical research, brings together oncologists and fertility specialists, and hopes to provide real options to young people who survive life-preserving but fertility-threatening treatments for cancer. The chapters in this book range from basic discovery research to reproductive medicine and from social science and the humanities to a section on stories from those who have survived cancer and have faced issues of fertility deprivation or restoration. Specifically, we have addressed three main areas: the underlying biological questions surrounding follicle growth and cryo-preservation of tissue; the application of the new technology to medical practice; and, the psychosocial implications of cancer-related infertility and oncofertility research for patients and their families. These questions are interlinking and require teams of investigators working in concert to solve a major unmet need. The book is a comprehensive initial definition of the field and we anticipate a great many more breakthroughs that will eventually provide a menu of options to those with fertility-threatening conditions. The editors thank the Specialized Cooperative Centers Program in Reproduction and Infertility Research (U54 HD041857) and the Institute for Women's Health Research of Northwestern University for funding and support of this book. Teresa K. In the past, pregnancy after cancer was largely unheard of. Today, it is increasingly a possibility. Oncofertility has emerged as an interdisciplinary field bridging biomedical and social sciences, and examining issues regarding an individual’s fertility options, choice and goals in light of cancer diagnosis, treatment and survivorship. Written by leaders in this evolving field, the volume covers various aspects: medical, ethical and social.